Reversible cystogenesis in juvenile primate ADPKD models: evidence from PKD1 heterozygous monkeys.
Shoma Matsumoto; Toshifumi Morimura; Kenichi Kobayashi; Keiichi Tsuji; Masataka Nakaya; Tomoyuki Tsukiyama; Ikuo Kawamoto; Takahiro Nakagawa; Etsuko Morishige; Koji Fukuda; Teppei Iwakiri; Kazuhiko Nozaki; Akihiro Kawauchi; Susumu Kageyama; Shinji Kume; Saori Nishio; Yasushi Itoh; Masatsugu Ema
Human molecular genetics, 23 Feb. 2026

Structure and thickness of Glisson's capsule differ considerably on the liver surface in mammalian species.
Hiroki Uchida; Naoyuki Aihara; Toshifumi Morimura; Shoma Matsumoto; Daichi Hasegawa; Tomoko Ichiki; Eiichi Okamura; Masanaga Muto; Go Sugahara; Toshio Miki; Masatsugu Ema; Kenichi Watanabe; Junichi Kamiie; Kinji Asahina
Anatomical record (Hoboken, N.J. : 2007), 09 Feb. 2025

APPトランスジェニックカニクイザルの脳脊髄液バイオマーカーの変化
柳沢 大治郎; 守村 敏史; 西村 正樹; 辻 敬一; 辻 篤司; 遠山 育夫; 依馬 正次; 石垣 診祐
Dementia Japan, Oct. 2024

Highly efficient transgenic mouse production using piggyBac and its application to rapid phenotyping at the founder generation
Eiichi Okamura; Seiya Mizuno; Shoma Matsumoto; Kazuya Murata; Yoko Tanimoto; Dinh Thi Huong Tra; Hayate Suzuki; Woojin Kang; Tomoka Ema; Kento Morimoto; Kanako Kato; Tomoko Matsumoto; Nanami Masuyama; Yusuke Kijima; Toshifumi Morimura; Fumihiro Sugiyama; Satoru Takahashi; Eiji Mizutani; Knut Woltjen; Nozomu Yachie; Masatsugu Ema
10 Dec. 2023, URL

APPトランスジェニックカニクイザルの開発 脳脊髄液バイオマーカー
柳沢 大治郎; 守村 敏史; 西村 正樹; 遠山 育夫; 依馬 正次; 石垣 診祐
Dementia Japan, Oct. 2023

APPトランスジェニックカニクイザルの開発 脳脊髄液バイオマーカー
柳沢 大治郎; 守村 敏史; 西村 正樹; 遠山 育夫; 依馬 正次; 石垣 診祐
Dementia Japan, Oct. 2023

In vivo analysis of aggregation propensity of low levels of mislocalized TDP-43 on cytopathological and behavioral phenotype of ALS/FTLD.
Hideki Wada; Ryota Hikiami; Makiko Kusui; Sumio Minamiyama; Megumi Asada-Utsugi; Akemi Shodai; Shin-Ichi Muramatsu; Toshifumi Morimura; Makoto Urushitani
Neuroscience research, 16 Feb. 2023

Conformational change of RNA-helicase DHX30 by ALS/FTD-linked FUS induces mitochondrial dysfunction and cytosolic aggregates.
Ryota Hikiami; Toshifumi Morimura; Takashi Ayaki; Tomoyuki Tsukiyama; Naoko Morimura; Makiko Kusui; Hideki Wada; Sumio Minamiyama; Akemi Shodai; Megumi Asada-Utsugi; Shin-Ichi Muramatsu; Takatoshi Ueki; Ryosuke Takahashi; Makoto Urushitani
Scientific reports, 26 Sep. 2022

Failure of DNA double-strand break repair by tau mediates Alzheimer's disease pathology in vitro.
Megumi Asada-Utsugi; Kengo Uemura; Takashi Ayaki; Maiko T Uemura; Sumio Minamiyama; Ryota Hikiami; Toshifumi Morimura; Akemi Shodai; Takatoshi Ueki; Ryosuke Takahashi; Ayae Kinoshita; Makoto Urushitani
Communications biology, 13 Apr. 2022

神経炎と血管新生におけるミトコンドリア性フェリチン(FtMt)の役割(Roles of mitochondrial ferritin(FtMt) in neuroinflammation and angiogenesis)
Buyandelger Undral; ウォカー・ダグラス; 柳沢 大治郎; 守村 敏史; 遠山 育夫
Dementia Japan, Oct. 2020

Effects of FTMT Expression by Retinal Pigment Epithelial Cells on Features of Angiogenesis
Undral Buyandelger; Douglas G. Walker; Daijiro Yanagisawa; Toshifumi Morimura; Ikuo Tooyama
International's Journal of Molecular Sciences, May 2020, Refereed, Not invited

Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein.
Yasunari Seita; Toshifumi Morimura; Naoki Watanabe; Chizuru Iwatani; Hideaki Tsuchiya; Shinichiro Nakamura; Toshiharu Suzuki; Daijiro Yanagisawa; Tomoyuki Tsukiyama; Masataka Nakaya; Eiichi Okamura; Masanaga Muto; Masatsugu Ema; Masaki Nishimura; Ikuo Tooyama
Journal of Alzheimer's disease : JAD, 2020, Refereed, Not invited

Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals.
MORIMURA Toshifumi
Scientific Reports, Apr. 2018, Refereed, Not invited

CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS
Tsukasa Uchida; Yoshitaka Tamaki; Takashi Ayaki; Akemi Shodai; Seiji Kaji; Toshifumi Morimura; Yoshinori Banno; Kazuchika Nishitsuji; Naomi Sakashita; Takakuni Maki; Hirofumi Yamashita; Hidefumi Ito; Ryosuke Takahashi; Makoto Urushitani
SCIENTIFIC REPORTS, Jan. 2016, Refereed, Not invited

Attenuation of endoplasmic reticulum stress in Pelizaeus-Merzbacher disease by an anti-malaria drug, chloroquine
Toshifumi Morimura; Yurika Numata; Shoko Nakamura; Eriko Hirano; Leo Gotoh; Yu-ich Goto; Makoto Urushitani; Ken Inoue
EXPERIMENTAL BIOLOGY AND MEDICINE, Apr. 2014, Not refereed, Not invited

Aberrant Assembly of RNA Recognition Motif 1 Links to Pathogenic Conversion of TAR DNA-binding Protein of 43 kDa (TDP-43)
Akemi Shodai; Toshifumi Morimura; Akemi Ido; Tsukasa Uchida; Takashi Ayaki; Rina Takahashi; Soichiro Kitazawa; Sakura Suzuki; Mikako Shirouzu; Takanori Kigawa; Yutaka Muto; Shigeyuki Yokoyama; Ryosuke Takahashi; Ryo Kitahara; Hidefumi Ito; Noriko Fujiwara; Makoto Urushitani
JOURNAL OF BIOLOGICAL CHEMISTRY, May 2013, Not refereed, Not invited

Depletion of Molecular Chaperones from the Endoplasmic Reticulum and Fragmentation of the Golgi Apparatus Associated with Pathogenesis in Pelizaeus-Merzbacher Disease
Yurika Numata; Toshifumi Morimura; Shoko Nakamura; Eriko Hirano; Shigeo Kure; Yu-ich Goto; Ken Inoue
JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2013, Not refereed, Not invited

Conserved Acidic Amino Acid Residues in a Second RNA Recognition Motif Regulate Assembly and Function of TDP-43
Akemi Shodai; Akemi Ido; Noriko Fujiwara; Takashi Ayaki; Toshifumi Morimura; Miki Oono; Tsukasa Uchida; Ryosuke Takahashi; Hidefumi Ito; Makoto Urushitani
PLOS ONE, Dec. 2012, Not refereed, Not invited

Effect of curcumin in a mouse model of Pelizaeus-Merzbacher disease
Li-Hua Yu; Toshifumi Morimura; Yurika Numata; Ryoko Yamamoto; Naoko Inoue; Barbara Antalfy; Yu-ichi Goto; Kimiko Deguchi; Hitoshi Osaka; Ken Inoue
MOLECULAR GENETICS AND METABOLISM, May 2012, Not refereed, Not invited

Relative importance of the tyrosine phosphorylation sites of Disabled-1 to the transmission of Reelin signaling
Toshifumi Morimura; Masaharu Ogawa
BRAIN RESEARCH, Dec. 2009, Not refereed, Not invited

Analysis of relative roles of the individual phosphotyrosines of Disabled-1 in Reelin signaling.
Neuroscience Research, 2009, Not refereed, Not invited

Analysis of relative roles of the individual phosphotyrosines of Disabled-1 in Reelin signaling
Toshifumi Morimura; Masaharu Ogawa
NEUROSCIENCE RESEARCH, 2009, Not refereed, Not invited

Visualizing spatiotemporal dynamics of multicellular cell-cycle progression
Asako Sakaue-Sawano; Hiroshi Kurokawa; Toshifumi Morimura; Aki Hanyu; Hiroshi Hama; Hatsuki Osawa; Saori Kashiwagi; Kiyoko Fukami; Takaki Miyata; Hiroyuki Miyoshi; Takeshi Imamura; Masaharu Ogawa; Hisao Masai; Atsushi Miyawaki
CELL, Feb. 2008, Not refereed, Not invited

Modulation of Reelin signaling by cyclin-dependent kinase 5
Toshio Ohshima; Hiromi Suzuki; Toshifumi Morimura; Masaharu Ogawa; Katsuhiko Mikoshiba
BRAIN RESEARCH, Apr. 2007, Not refereed, Not invited

A role of Disable-1 as a transcription factor in Reelin signaling
Toshifumi Morimura; Chihiro Hisatsune; Mitsuharu Hattori; Katsuhiko Mikoshiba; Masaharu Ogawa
NEUROSCIENCE RESEARCH, 2007, Not refereed, Not invited

The presence of the p53 transcripts with truncated open reading frames in Marek's disease tumor-derived cell lines
Michihiro Takagi; Kazuhiko Ohashi; Toshifumi Morimura; Chihiro Sugimoto; Misao Onuma
LEUKEMIA RESEARCH, Aug. 2006, Not refereed, Not invited

Disabled1 regulates the intracellular trafficking of Reelin receptors
T Morimura; M Hattori; M Ogawa; K Mikoshiba
JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2005, Not refereed, Not invited

Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1
S Suetsugu; T Tezuka; T Morimura; M Hattori; K Mikoshiba; T Yamamoto; T Takenawa
BIOCHEMICAL JOURNAL, Nov. 2004, Not refereed, Not invited

Notch signaling suppresses IgH gene expression in chicken B cells: Implication in spatially restricted expression of Serrate2/Notch1 in the bursa of Fabricius
T Morimura; S Miyatani; D Kitamura; R Goitsuka
JOURNAL OF IMMUNOLOGY, Mar. 2001, Not refereed, Not invited

Application of representational difference analysis to genomic fragments of Marek's disease virus
D Endoh; KO Cho; K Tsukamoto; T Morimura; Y Kon; M Hayashi
JOURNAL OF CLINICAL MICROBIOLOGY, Dec. 2000, Not refereed, Not invited

Cell cycle arrest and apoptosis induced by Notch1 in B cells
Toshifumi Morimura; Ryo Goitsuka; Yong Zhang; Izumu Saito; Michael Reth; Daisuke Kitamura
Journal of Biological Chemistry, 24 Nov. 2000, Not refereed, Not invited

Expression of bcl-2 and bcl-x genes in lymphocytes and tumor cell lines derived from MDV-infected chickens
K Ohashi; T Morimura; M Takagi; SI Lee; KO Cho; H Takahashi; Y Maeda; C Sugimoto; M Onuma
ACTA VIROLOGICA, Apr. 1999, Not refereed, Not invited

Anti-viral and anti-tumor effects induced by an attenuated Marek's disease virus in CD4-or CD8-deficient chickens
T Morimura; KO Cho; Y Kudo; Y Hiramoto; K Ohashi; M Hattori; C Sugimoto; M Onuma
ARCHIVES OF VIROLOGY, 1999, Not refereed, Not invited

Re-isolation of Marek's disease virus from T cell subsets of vaccinated and non-vaccinated chickens
SI Lee; K Ohashi; T Morimura; C Sugimoto; M Onuma
ARCHIVES OF VIROLOGY, 1999, Not refereed, Not invited

Cutting edge: BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius
R Goitsuka; Y Fujimura; H Mamada; A Umeda; T Morimura; K Uetsuka; K Doi; S Tsuji; D Kitamura
JOURNAL OF IMMUNOLOGY, Dec. 1998, Not refereed, Not invited

Analysis of tumor suppressor gene p53 in chicken lymphoblastoid tumor cell lines and field tumors
M Takagi; K Ohashi; T Morimura; C Sugimoto; M Onuma
JOURNAL OF VETERINARY MEDICAL SCIENCE, Aug. 1998, Not refereed, Not invited

Retroviral sequence located in border region of short unique region and short terminal repeat of Md5 strain of Marek's disease virus type 1
D Endoh; M Ito; KO Cho; Y Kon; T Morimura; M Hayashi; M Kuwabara
JOURNAL OF VETERINARY MEDICAL SCIENCE, Feb. 1998, Not refereed, Not invited

Pathogenesis of Marek's disease (MD) and possible mechanisms of immunity induced by MD vaccine
T Morimura; K Ohashi; C Sugimoto; M Onuma
JOURNAL OF VETERINARY MEDICAL SCIENCE, Jan. 1998, Not refereed, Not invited

Phenotype analysis of lymphoid cells in Marek's disease of CD4(+) or CD8(+) T-cell-deficient chickens: occurrence of double negative T-cell tumour
K Okada; Y Tanaka; K Murakami; S Chiba; T Morimura; M Hattori; M Goryo; M Onuma
AVIAN PATHOLOGY, Sep. 1997, Not refereed, Not invited

Apoptosis in peripheral CD4⁺ T cells and thymocytes by Marek\\'s disease virus-infection
T. Morimura; K. Ohashi; Y. Kon; M. Hattori; C. Sugimoto; H. Onuma
Leukemia, 1997, Refereed, Not invited

Morimura, T., Ohashi, K., Kon, Y., Hattori, M., Sugimoto, C., and Onuma, M
Leukemia, 1997, Not refereed, Not invited

Morimura, T., Ohashi, K., Kon, Y., Hattori, M., Sugimoto, C., and Onuma, M
Leukemia, 1997, Not refereed, Not invited

Detection of transcripts of Marek's disease virus serotype 1 ICP4 homologue (MDV1 ICP4) by in situ hybridization
D Endoh; Y Kon; M Hayashi; T Morimura; KO Cho; T Iwasaki; F Sato
JOURNAL OF VETERINARY MEDICAL SCIENCE, Oct. 1996, Not refereed, Not invited

Apoptosis is of CD4(+) T cell in vivo and nonresponsiveness of Cd4(+) and Cd8(+) T cells in vitro observed in chickens infected with Marek's disease virus
T Morimura; K Ohashi; M Hattori; C Sugimoto; M Onuma
CURRENT RESEARCH ON MAREK'S DISEASE, 1996, Refereed, Not invited

Apoptosis and CD8-down-regulation in the thymus of chickens infected with Marek's disease virus
T. Morimura; K. Ohashi; Y. Kon; M. Hattori; C. Sugimoto; M. Onuma
Archives of Virology, 1996, Not refereed, Not invited

Apoptosis and CD8-down-regulation in the thymus of chickens infected with Marek's disease virus
Archives of Virology, 1996, Not refereed, Not invited

IMMUNOMODULATION OF PERIPHERAL T-CELLS IN CHICKENS INFECTED WITH MAREKS-DISEASE VIRUS - INVOLVEMENT IN IMMUNOSUPPRESSION
T MORIMURA; M HATTORI; K OHASHI; C SUGIMOTO; M ONUMA
JOURNAL OF GENERAL VIROLOGY, Dec. 1995, Not refereed, Not invited

Immunomodulation of peripheral T cells in chickens infected with Marek's disease virus: Involvement in immunosuppression
T. Morimura; M. Hattori; K. Ohashi; C. Sugimoto; M. Onuma
Journal of General Virology, 1995, Not refereed, Not invited

APP遺伝子改変カニクイザルのアルツハイマー病脳脊髄液バイオマーカーの解析
柳沢大治郎; 守村敏史; 西村正樹; 遠山育夫; 依馬正次; 石垣診祐
日本生物学的精神医学会(Web), 2024

バイオマテリアルとしてのカニクイザル不死化Bリンパ球バンクの構築
守村敏史; 伊藤靖; 等誠司; 遠山育夫; 依馬正次
日本獣医学会学術集会講演要旨集, 2021

Roles of mitochondrial ferritin (FtMt) in neuroinflammation and angiogenesis
UNDRAL Buyandelger; ウォカー ダグラス; 柳沢大治郎; 守村敏史; 遠山育夫
Dementia Japan, 2020

アルツハイマー病関連変異型amyloid precursor protein発現トランスジェニックカニクイザルの作出
守村敏史; 清田弥寿成; 渡邊直希; 岩谷千鶴; 土屋英明; 中村紳一郎; 鈴木利治; 依馬正次; 西村正樹; 遠山育夫
日本脳科学会プログラム・講演抄録集, 2019

骨髄単核球の細胞保護型ミクログリア細胞への分化誘導法の検討―神経変性疾患の細胞治療への応用をめざして―
小橋修平; 寺島智也; 中江由希; 樫美和子; 守村敏史; 小島秀人; 漆谷真
再生医療, 01 Feb. 2017, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201702253718506566

VHLとCUL2 TDP-43の凝集を促進するVHLと分解を促進するCUL2
内田 司; 小代 明美; 玉木 良高; 辰己 新水; 守村 敏史; 綾木 孝; 伊東 秀文; 坂下 直実; 高橋 良輔; 漆谷 真
臨床神経学, Dec. 2015, Not refereed, Not invited

TDP-43のCullin-2型E3リガーゼの同定及び機能解析
内田 司; 守村 敏史; 小代 明美; 大野 美樹; 高橋 良輔; 漆谷 真
臨床神経学, Dec. 2014, Not refereed, Not invited

病態に根ざしたALSの新規治療法開発 野生型SOD1蛋白質の毒性転化と孤発性ALSにおける病態修飾因子としての可能性について
漆谷真; 大野美樹; 守村敏史; 藤原範子; 松本紋子; 谷口直之; 阿部康二; 高橋良輔
神経変性疾患に関する調査研究班 分科班「病態に根ざしたALSの新規治療法開発」 平成25年度 研究報告書, 2014

ミスフォールド蛋白質による神経細胞死と治療戦略
遺伝子医学MOOK別冊「細胞死研究の今－疾患との関わり、創薬に向けてのアプローチ」, 2013, Not refereed, Not invited

Establishment of a medicine against the endoplasmic reticulum stress in Pelizaeus-Merzbacher disease
Toshifumi Morimura; Yurika Numata; Eriko Arima; Yuichi Goto; Ken Inoue
NEUROSCIENCE RESEARCH, 2011, Not refereed, Not invited

BASH, B-cell specific adaptor containing an SH2 domain, involved in antigen-receptor signaling
KITAMURA Daisuke; FUJIMURA Shuichi; OKAMOTO Noriaki; HAYASHI Katsuhiko; MAMADA Hiroshi; UMEDA Akiko; MORIMURA Toshifumi; TSUJI Sachiyo; GOITSUKA Ryo
日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

マレック病ウイルスによる腫瘍化とアポトーシス 相反する現象に発癌遺伝子 bcl-2 ファミリーが関与
大橋 和彦; 守村 敏史; 高木 道浩; 杉本 千尋; 小沼 操
化学と生物, 25 Nov. 1997, Not refereed, Not invited

Molecular Targeted Therapy against Amyotrophic Lateral Sclerosis. In Amyotrophic Lateral Sclerosis: Symptoms, Treatment and Prognosis.
Nova Science Publishers, Inc, 2013, Not refereed

Molecular Targeted Therapy against Amyotrophic Lateral Sclerosis. In Amyotrophic Lateral Sclerosis: Symptoms, Treatment and Prognosis.
Nova Science Publishers, Inc, 2013, Not refereed

Aug. 2020, Present
Japanese Association for Laboratory Animal Science

Present
Japanese Society of Veterinary Science

The Japan Neuroscinece Society

Pathological and diagnostic significance of the N-terminal fragment of TDP-43 in ALS
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
01 Apr. 2024, 31 Mar. 2027

新規ミトコンドリア蛋白質の構造異常によるALS病態の解析と評価モデル系の開発
基盤研究(B)
滋賀医科大学
01 Apr. 2022, 31 Mar. 2026

新規ミトコンドリア蛋白質の構造異常によるALS病態の解析と評価モデル系の開発
基盤研究(B)
滋賀医科大学
01 Apr. 2022, 31 Mar. 2026

PKD遺伝子異常に伴う脳動脈瘤発生の病態解明
基盤研究(C)
滋賀医科大学
01 Apr. 2022, 31 Mar. 2025

Drug discovery against ER stress by using a novel luminescence probe sensing ER environments
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
01 Apr. 2020, 31 Mar. 2023

Pathological and therapeutic research of sporadic ALS
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
01 Apr. 2017, 31 Mar. 2020

Development of a novel molecular targeting therapy and probe, using antibodies against pathogenic epitopes in TDP-43
Grant-in-Aid for Scientific Research (B)
01 Apr. 2014, 31 Mar. 2018

Analysis of ALS related gene products in the mouse central nerve system
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
01 Apr. 2014, 31 Mar. 2017

Clinical application of autophagy-inducing factors from food supplements
Grant-in-Aid for Scientific Research (C)
2011, 2013

Functional analysis of Dab1as a transcription factor for transmission of Reelin signaling
Grant-in-Aid for Scientific Research (C)
The Institute of Physical and Chemical Research
2008, 2010

細胞内アダプター蛋白質Dab1によるニューロンの位置決定機構の解析
若手研究(B)
独立行政法人理化学研究所
2006, 2007

大脳皮質の構築に必須なアダプター蛋白質Dab1及びその結合蛋白質の機能解析
若手研究(B)
独立行政法人理化学研究所
2003, 2004