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SATOOKA Hiroki
Division of Biology

Researcher information

■ Degree
  • Ph.D., University of California, Berkeley
■ Research Keyword
  • Nox2
  • 自己抗体産生
  • 濾胞性ヘルパーT細胞
  • シングルセル
  • ケモカイン
  • NK細胞
  • 川崎病
  • 細胞治療・再生治療
  • 自己免疫疾患
  • 制御性T細胞
  • Chemical Biology
  • Molecular Biology
  • Cell Biology
  • Tumor/Tumor microenvironment
  • Immunology
  • Redox Biology
■ Field Of Study
  • Life sciences/Experimental pathology, 自己免疫疾患・がん免疫
  • Life sciences/Immunology, バイオインフォマティクス
  • Life sciences/Medical biochemistry, レドックスバイオロジー
  • Life sciences/Immunology, 制御性T細胞・自己免疫疾患
  • Life sciences/Fetal medicine/Pediatrics, 川崎病

Career

■ Career
  • Jul. 2022 - Present
    Shiga University of Medical Science, 生命科学講座(生物学), 准教授
  • Apr. 2016 - Jun. 2022
    Shiga University of Medical Science, 生命科学講座(生物学), 助教
  • Apr. 2012 - Mar. 2016
    京都大学医学研究科, 特定研究員
■ Educational Background
  • Sep. 2007 - Dec. 2011
    University of California, Berkeley, Nutritional Science & Toxicology, Molecular Toxicology, Ph.D.
  • Sep. 2005 - May 2007
    University of California, Berkeley, Molecular & Cellular Biology, Genetics, B.A.
  • Sep. 2005 - May 2007
    University of California, Berkeley, Chemistry, Chemical Biology, B.S.
  • Sep. 2003 - Jun. 2005
    University of California, Santa Barbara, Chemistry, Biochemistry

Research activity information

■ Award
  • Oct. 2009
    International Conference of Nutrition, Distinguished poster
  • Oct. 2009
    International Conference of Nutrition, Travel Award
  • Mar. 2009
    University of California, Berkeley, Travel Award by Graduate Assembly
■ Paper
  • Transduction of Batf family members provides distinct functions to mouse CD8+ T cells.
    Kenta Kondo; Mina Kumode; Hiroki Satooka; Koji Terada; Yusuke Sano; Nobuhito Nitta; Daisuke Okuzaki; Kensuke Takada; Takako Hirata; Hidetaka Kosako; Akira Andoh; Makoto Murata; Yasutoshi Agata
    Int. Immunol., 17 Feb. 2026, Refereed
  • Intravenous anesthetic propofol suppresses T cell–dependent antibody production in mice
    Hiraoka S; Satooka H; Kitagawa H; Hirata T
    J. Anesth., Jun. 2025, Refereed, Corresponding, URL
  • ROS-dependent SOCS3 upregulation disrupts regulatory T cell stability during autoimmune disease development
    Satooka H.; Nakamura Y.; Hirata T.
    Redox Biol., Mar. 2025, Refereed, Not invited, Lead
  • Moesin deficiency leads to lupus-like nephritis with accumulation of CXCL13-producing patrolling monocytes
    Ichioka S; Satooka H; Maruo Y; Hirata T
    Biochem. Biophys. Res. Commun., Apr. 2024, Refereed, Corresponding
  • Intracellular oxidation of methyl p-coumarate is involved in anti-melanogenic and cytotoxic activities against melanoma cells
    Satooka H; Nihe Ki; Kubo I
    Phytochem. Lett., Aug. 2022, Refereed
  • Prooxidative effect of cardols is involved in their cytotoxic activity against murine B16–F10 melanoma cells
    Satooka H; Kubo I
    Biochem. Biophys. Res. Commun., Jun. 2022, Refereed
  • Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model
    Terada K; Kondo K; Ishigaki H; Nagashima A; Satooka H; Nagano S; Masuda K; Kawamura T; Hirata T; Ogasawara K; Itoh Y; Kawamoto H; Agata Y
    Mol. Ther.-Oncolytics, Mar. 2022, Refereed
  • The effect of ethanol on disassembly of amyloid-β1-42 pentamer revealed by atomic force microscopy and gel electrophoresis
    Matsui A; Bellier J-P; Kanai T; Satooka H; Nakanishi A; Terada T; Ishibe T; Nakamura Y; Taguchi H; Naruse N; Mera Y
    Int. J. Mol. Sci., 14 Jan. 2022, Refereed, URL
  • The ERM protein moesin regulates natural killer cell homeostasis in vivo
    Satooka H; Matsui M; Ichioka S; Nakamura Y; Hirata T
    Cell. Immunol., Jan. 2022, Refereed, Not invited, Lead
  • Alteration in endometrial helper T‐cell subgroups in chronic endometritis
    Kitazawa J; Kimura F; Nakamura A; Morimune A; Hanada T; Amano T; Tsuji S; Kasahara K; Satooka H; Hirata T; Kushima R; Murakami T
    Am. J. Reprod. Immunol., 25 Nov. 2020, Refereed, Not invited, Corresponding
  • Citrullinated fibrinogen is a target of auto-antibodies in interstitial lung disease in mice with collagen-induced arthritis
    Sato T; Satooka H; Ichioka S; Maruo Y; Hirata T
    Int. Immunol., 28 Jul. 2020, Refereed, Not invited
  • A novel Siglec-F+ neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model
    Matsui M; Nagakubo D; Satooka H; Hirata T
    Biochem. Biophys. Res. Commun., 04 Jun. 2020, Refereed, Not invited
  • Characterization of tumour-infiltrating lymphocytes in a tumour rejection cynomolgus macaque model
    Satooka H; Ishigaki H; Todo K; Terada K; Agata Y; Itoh Y; Ogasawara K; Hirata T
    Sci. Rep., 21 May 2020, Refereed, Not invited, Lead
  • Polygonum odoratum essential oil inhibits the activity of mushroom derived tyrosinase
    Murray AF; Satooka H; Shimizu K; Chavasiri W; Kubo I
    Heliyon, 27 Nov. 2019, Refereed, Not invited
  • Oligomers imaging of amyloid-β 1-42 by scanning tunneling microscopy
    Naruse N; Satooka H; Todo K; Nakanishi A; Taguchi H; Mera Y
    Jpn. J. Appl. Phys., 01 Aug. 2019, Refereed, Not invited
  • The ERM protein moesin regulates CD8+ regulatory T cell homeostasis and self-tolerance.
    Satooka H; Nagakubo D; Sato T; Hirata T
    J. Immunol., 15 Nov. 2017, Refereed, Not invited, Lead
  • Effects of matsutake mushroom scent compounds on tyrosinase and murine B16-F10 melanoma cells
    Satooka H; Cerda P; Kim H-J; Wood WF; Kubo I
    Biochem. Biophys. Res. Commun., 10 Jun. 2017, Refereed, Not invited, Lead
  • Role of mitochondrial hydrogen peroxide induced by intermittent hypoxia in airway epithelial wound repair in vitro
    Hamada S; Sato A; Hara-Chikuma M; Satooka H; Hasegawa K; Tanimura K; Tanizawa K; Inouchi M; Handa T; Oga T; Muro S; Mishima M; Chin K
    Exp. Cell Res., 15 May 2016, Refereed, Not invited
  • Involvement of aquaporin-3 in epidermal growth factor receptor signaling via hydrogen peroxide transport in cancer cells
    Hara-Chikuma M; Watanabe S; Satooka H
    Biochem. Biophys. Res. Commun., 18 Mar. 2016, Refereed, Not invited, Last
  • Aquaporin-3 Controls Breast Cancer Cell Migration by Regulating Hydrogen Peroxide Transport and Its Downstream Cell Signaling
    Satooka H; Hara-Chikuma M
    Mol. Cell. Biol., 01 Feb. 2016, Refereed, Not invited, Lead
  • Aquaporin-3-mediated hydrogen peroxide transport is required for NF-kappa B signalling in keratinocytes and development of psoriasis
    Hara-Chikuma M; Satooka H; Watanabe S; Honda T; Miyachi Y; Watanabe T; Verkman AS
    Nat. Commun., 23 Jun. 2015, Refereed, Not invited
  • Melanogenesis inhibitors from Rabdosia japonica
    Satooka H; Isobe T; Nitoda T; Kubo I
    Phytomedicine, 15 Aug. 2012, Refereed, Not invited, Lead
  • Effects of Thymol on B16-F10 Melanoma Cells
    Satooka H; Kubo I
    J. Agric. Food Chem., 14 Mar. 2012, Refereed, Not invited, Lead
  • Resveratrol as a kcat type inhibitor for tyrosinase: Potentiated melanogenesis inhibitor
    Satooka H; Kubo I
    Bioorg. Med. Chem., 15 Jan. 2012, Refereed, Not invited
  • Effects of Thymol on Mushroom Tyrosinase-Catalyzed Melanin Formation
    Satooka H; Kubo, I
    J. Agric. Food Chem., 24 Aug. 2011, Refereed, Not invited, Lead
  • Insect growth inhibitory activity and cytotoxicity of tannic acid from Gallae Rhois.
    Kubo I; Hori I; Nihei K; Satooka H; Cespedes CL; Calderon JS
    Biopestic. Int., 2008, Refereed, Not invited
■ MISC
  • Naturally occurring melanin synthesis regulators and their modes of action.
    Satooka H
    University of California, Berkeley, Ph.D. Dissertation, Dec. 2011, Not refereed
    Lead
■ Lectures, oral presentations, etc.
  • ROS-dependent SOCS3 upregulation disrupts regulatory T cell stability during autoimmune disease development
    Satooka H; Nakamura Y; Hirata T
    International Congress of Medicine and Health 2026, 03 Jul. 2026, Invited
  • Moesin regulates homeostasis of alveolar epithelial cells and macrophages
    Satooka H; Hirata T
    第54回日本免疫学会学術集会, 11 Dec. 2025
  • Moesin regulates homeostasis of alveolar epithelial cells and macrophages
    Satooka H; Hirata T
    第53回日本免疫学会学術集会, 04 Dec. 2024, Not invited
  • Propofol suppresses antibody production in a T-cell dependent manner
    Hiraoka S; Satooka H; Hirata T
    第53回日本免疫学会学術集会, Dec. 2024
  • レドックス反応から疾患を理解する
    里岡 大樹
    JST共創の場形成支援プログラム(COI-NEXT)第34回若手人材育成セミナー, 30 Aug. 2024, Invited
  • Propofol suppresses antibody production against T cell-dependent antigen
    平岡進; 里岡大樹; 平田多佳子; 北川裕利
    日本麻酔科学会学術集会(Web), Jun. 2024
  • Effects of intravenous anesthetics on adaptive immunity
    Hiraoka S; Satooka H; Hirata T
    第52回日本免疫学会学術集会, Jan. 2024
  • The mechanism of coronary arteritis in Kawasaki disease model mice
    Fujita M; Satooka H; Hoshino S; Hirata T
    第52回日本免疫学会学術集会, Jan. 2024
  • ナルディライジンに着目した自己免疫性肝炎の病態解明
    吉田晋也; 西清人; 里岡大樹; 大野美紀子; 平田多佳子; 安藤朗; 西英一郎
    第28回日本病態プロテアーゼ学会学術集会, Aug. 2023
  • NADPH oxidase regulates the stability of regulatory T cells and the development of autoimmunity
    Satooka H; Hirata T
    第51回日本免疫学会学術集会, 09 Dec. 2022
  • Moesin deficiency leads to the local CXCL13 expression and inflammation in the kidney
    Ichioka S; Satooka H; Hirata T
    第51回日本免疫学会学術集会, Dec. 2022
  • Redox-mediated SOCS3 expression in regulatory T cells is involved in the development of autoimmunity
    Satooka H
    14th Asian Natural Product Conference, 11 Nov. 2022, Invited
  • 免疫応答中のIgDの分泌型の産生
    Todo K.; Satooka H.; Hirata T.
    第50回日本免疫学会学術集会, Dec. 2021
  • Redox-mediated SOCS3 expression in regulatory T cells is involved in the development of autoimmunity.
    Satooka H; Nakamura Y; Todo K; Hirata T
    第50回日本免疫学会学術集会, Dec. 2021
  • カニクイザルの腫瘍拒絶モデルにおける腫瘍浸潤T細胞からの腫瘍殺傷能をもつTCR遺伝子の単離
    寺田晃士; 石垣宏仁; 近藤健太; 長嶋彩花; 里岡大樹; 永野誠治; 増田喬子; 川村晃久; 河本宏; 平田多佳子; 小笠原一誠; 伊藤靖; 縣保年
    日本分子生物学会年会, Dec. 2020
  • カニクイザルの腫瘍浸潤T細胞から腫瘍殺傷能を有するTCR遺伝子を単離する
    近藤健太; 寺田晃士; 石垣宏仁; 里岡大樹; 永野誠治; 増田喬子; 平田多佳子; 小笠原一誠; 伊藤靖; 河本宏; 縣保年
    日本がん免疫学会総会, Oct. 2020
  • Redox-mediated signaling in regulatory T cells is involved in the development of autoimmunity
    Satooka H, Sato T, Nakamura Y, Todo K, Hirata T.
    第48回日本免疫学会学術集会, 13 Dec. 2019
  • I型過敏性におけるIgD発現細胞の関与
    Todo K; Asano K; Satooka H; Hirata T
    第48回日本免疫学会学術集会, Dec. 2019
  • Redox-mediated regulatory T cell homeostasis and its involvement in autoimmunity
    Satooka H; Sato T; Nakamura Y; Hirata T
    第47回日本免疫学会学術集会, 12 Dec. 2018, Not invited
  • ERMタンパク質moesinによるCD8+ Tregの恒常的維持とその自己免疫疾患への関与
    里岡 大樹; 長久保 大輔; 佐藤 知美; 平田 多佳子
    第28回 Kyoto T Cell Conference, 16 Jun. 2018
  • Impaired CD8+ regulatory T cell homeostasis and self-tolerance in moesin-deficient mice
    Satooka H; Nagakubo D; Sato T; Hirata T
    7th International Workshop of Kyoto T Cell Conference, 17 Mar. 2018
  • The ERM protein moesin regulates CD8+ regulatory T cell homeostasis and self-torelance
    Satooka H, Nagakubo D, Sato T, Hirata T.
    第46回日本免疫学会学術集会, 14 Dec. 2017
  • Characterization of rheumatoid arthritis-associated interstitial pneumonia using collagen-induced arthritis mice
    Sato T; Satooka H; Nagakubo D; Hirata T
    第46回日本免疫学会学術集会, Dec. 2017
  • アクアポリン 3 の過酸化水素透過を介した乳癌細胞遊走・転移 のメカニズム
    里岡 大樹、竹馬 真理子
    第 18 回がん分子治療標的学会学術集会, Jun. 2014, Not invited
  • The role of aquaporin-3-mediated hydrogen peroxide transport inbreastcancercellmigrationandmetastasis.
    Satooka H; Chikuma M
    第72回日本癌学会学術総会, Oct. 2013, Not invited
  • アクアポリン 3 の過酸化水素透過を介した乳癌細胞遊走のメカ ニズム
    里岡 大樹; 竹馬 真理子
    第 17 回がん分子治療標的学会学術集会, Jun. 2013, Not invited
  • Resveratrol as a kcat type inhibitor of tyrosinase enzyme: Potentials as a melanogenesis inhibition.
    Satooka H; Kubo I
    240th American Chemical Society National Meeting & Exposition, Aug. 2010, Not invited
  • Vietnamese coriander as a functional nutrient.
    Satooka H; Kubo I
    19th International Congress of Nutrition, Oct. 2009, Not invited
  • Effects of phenylpropanoids on murine B16-F10 melanoma cells.
    Satooka H; Kubo I
    2009 American Association for Advancement of Science (AAAS) Pacific Division Meeting, Aug. 2009, Not invited
  • Effects of eugenol on murine B16-F10 melanoma cells.
    Satooka H; Kubo I
    238th American Chemical Society National Meeting & Exposition, Aug. 2009, Not invited
  • Berry fruits as functional nutrients.
    Satooka H; Kubo I
    2009 Berry Health Benefits Symposium, Jun. 2009, Not invited
  • Effects of thymol and carvacrol on murine B16-F10 melanoma cells.
    Satooka H; Kubo I
    American Chemical Society National Meeting & Exposition, Mar. 2009, Not invited
  • Novel mechanism of cellular effects of arbutin – toxicity and melanogenesis inhibition on B16-F10 murine melanoma cells.
    Satooka H; Kubo I
    American Association for the Advancement of Science (AAAS) 2009 Annual Meeting, Feb. 2009, Not invited
■ Research Themes
  • 濾胞性ヘルパーT細胞におけるNox2の発現意義とその自己免疫疾患における役割
    基盤研究(C)
    滋賀医科大学
    Apr. 2026, Mar. 2029
  • 川崎病関連ナチュラルキラー細胞による川崎病冠動脈の病態形成機構の解明とそれによる治療戦略
    Apr. 2026, Mar. 2027
  • レドックスシグナルによる末梢性免疫寛容制御機構の解明
    基盤研究(C)
    滋賀医科大学
    01 Apr. 2023, 31 Mar. 2026
  • 川崎病関連ナチュラルキラー細胞による川崎病冠動脈炎の病態形成メカニズムの解明
    Apr. 2025, Mar. 2026
  • CX3CR1陽性ナチュラルキラー細胞による川崎病冠動脈炎の病態形成メカニズムの解明
    Dec. 2024, Dec. 2025
  • 川崎病モデルを用いたCX3CR1陽性ナチュラルキラー細胞による川崎病冠動脈炎の病態形成メカニズムの解明
    Dec. 2024, Dec. 2025
  • iPS細胞技術による抗原特異的CD8 Tregの再生方法の確立とその自己免疫疾患治療への応用
    Apr. 2020, Mar. 2022
  • moesinを中心とした慢性閉塞性肺疾患発症メカニズムの解明
    Apr. 2020, Mar. 2021
  • iPS細胞技術を用いた抗原特異的CD8 Tregの再生による自己免疫疾患の制御
    Jul. 2018, Mar. 2020
  • Redox-mediated Treg homeostasis is involved in the development of autoimmunity
    Grant-in-Aid for Early-Career Scientists
    Shiga University of Medical Science
    Apr. 2018, Mar. 2020
  • iPS細胞技術を用いたCD8 陽性制御性T細胞の再生による自己免疫疾患の治療を目指した研究
    Dec. 2018, Dec. 2019
  • iPS細胞技術による抗原特異的CD8 Tregの再生とその自己免疫疾患治療への応用
    Oct. 2018, Oct. 2019
  • CD8陽性制御性T細胞の自己免疫疾患治療への応用
    Apr. 2018, Jun. 2019
  • Molecular mechanisms and control of immune cell migration to skin and mucosa
    Grant-in-Aid for Scientific Research (C)
    Shiga University of Medical Science
    21 Oct. 2016, 31 Mar. 2019