Feb. 2026
滋賀医科大学ピッチコンテスト, 最優秀賞

Mar. 2024
滋賀医科大学医学部附属病院 医師臨床教育センター, 優秀研修医賞

Jun. 2022
日本神経病理学会, 第63回日本神経病理学会学術総会 優秀演題賞

Nov. 2019
日本脳科学会, 第46回日本脳科学会 奨励賞

Mar. 2017
Johns Hopkins University School of Medicine, Department of Pathology, Outstanding Abstract in Basic research category at the 19th Annual Department of Pathology Young Investigators’ Day

May 2010
Department of Molecular & Biomedical Sciences at the University of Maine, Outstanding Graduate Research Award

浸潤性腺癌との鑑別を要した偽浸潤・上皮迷入を伴う横行結腸管状腺腫の1例
杉村 周亮; 景山 裕介; 五十川 賢司; 藤本 汐莉; 田中 えり; 能島 舞; 松原 亜季子; 森谷 鈴子; 九嶋 亮治
診断病理, Oct. 2025, URL

Sizes of amyloid-β oligomers predicted using atomic force microscopy and two-point crosslinked dimers as standards.
Chikara Harada; Atsuya Matsui; Yumi Irie; Ayumi Uchino; Ayaka Chikugo; Kotaro Fujii; Katsuma Hosoi; Akio Nakanishi; Yusuke Kageyama; Nobuyasu Naruse; Chihiro Tsukano; Kazuhiro Irie; Yutaka Mera
Chemical communications (Cambridge, England), 23 May 2025, Refereed

Identification of the binding site and immunoreactivity of anti-Aβ antibody 11A1: Comparison with the toxic conformation-specific TxCo-1 antibody
Rara Fukui; Uswah Hafizal; Yusuke Kageyama; Yumi Irie; Yuka Matsushima; Katsuma Hosoi; Takahisa Nakayama; Daita Kaneda; Yoshio Hashizume; Kunio Miki; Akiko Kita; Ken-ichi Mukaisho; Ryoji Kushima; Ikuo Tooyama; Kazuhiro Irie
Biochemical and Biophysical Research Communications, Mar. 2025, Refereed, Corresponding

Metabolic analysis of three-dimensional cultured gastrointestinal cancer cells suggests that L-arginine inhibits tumor growth by affecting the urea cycle.
Eri Tanaka; Naoko Taniura; Ken-Ichi Mukaisho; Yusuke Kageyama; Mai Noujima; Hirohito Ishigaki; Takahisa Nakayama; Ryoji Kushima
Pathobiology : journal of immunopathology, molecular and cellular biology, 10 Dec. 2024, Refereed

Three-Dimensional Culture of Glioblastoma Cells Using a Tissueoid Cell Culture System.
Natsume Okamoto; Naoko Taniura; Takahisa Nakayama; Eri Tanaka; Yusuke Kageyama; Mai Noujima; Ryoji Kushima; Ken-Ichi Mukaisho
Acta histochemica et cytochemica, 28 Oct. 2024, Refereed

リンチ症候群を背景とする自己免疫性胃炎に併発した多発胃腫瘍の1例
景山 裕介; 木村 英憲; 松原 亜季子; 安藤 朗; 九嶋 亮治
日本病理学会会誌, Feb. 2024

新規3次元培養を用いたL-アルギニンの上部消化管がん細胞に対する抗がんメカニズムの解明
田中 えり; 谷浦 直子; 向所 賢一; 景山 裕介; 能島 舞; 仲山 貴永; 九嶋 亮治
日本病理学会会誌, Feb. 2024

Visualization of Amyloid Oligomers in the Brain of Patients with Alzheimer’s Disease
Ikuo Tooyama; Tomoko Kato; Hiroyasu Taguchi; Yusuke Kageyama; Kazuhiro Irie; Yukie Hirahara; Daijiro Yanagisawa
ACTA HISTOCHEMICA ET CYTOCHEMICA, 28 Dec. 2023, URL

Immunohistochemical Analysis of Mitochondrial Ferritin in the Midbrain of Patients with Parkinson’s Disease
Haruka Tsubaki; Daijiro Yanagisawa; Yusuke Kageyama; Zulzikry Hafiz Abu Baker; Ken-ichi Mukaisho; Ikuo Tooyama
ACTA HISTOCHEMICA ET CYTOCHEMICA, 25 Apr. 2023, Refereed

Optimization of the Linker Length in the Dimer Model of E22P-Aβ40 Tethered at Position 38
Ayaka Chikugo; Yumi Irie; Chihiro Tsukano; Ayumi Uchino; Takahito Maki; Toshiaki Kume; Taiji Kawase; Kenji Hirose; Yusuke Kageyama; Ikuo Tooyama; Kazuhiro Irie
ACS Chemical Neuroscience, 12 Sep. 2022, Refereed

Synthesis and Characterization of Propeller- and Parallel-Type Full-Length Amyloid β40 Trimer Models
Ayumi Uchino; Yumi Irie; Chihiro Tsukano; Taiji Kawase; Kenji Hirose; Yusuke Kageyama; Ikuo Tooyama; Ryo C. Yanagita; Kazuhiro Irie
ACS Chemical Neuroscience, 05 Aug. 2022, Refereed

Structure Optimization of the Toxic Conformation Model of Amyloid β42 by Intramolecular Disulfide Bond Formation
Yuka Matsushima; Yumi Irie; Yusuke Kageyama; Jean‐Pierre Bellier; Ikuo Tooyama; Takahito Maki; Toshiaki Kume; Ryo C. Yanagita; Kazuhiro Irie
ChemBioChem, 03 Mar. 2022, Refereed, URL

Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain
Yusuke Kageyama; Yumi Irie; Yuka Matsushima; Tatsuya Segawa; Jean-Pierre Bellier; Kumi Hidaka; Hiroshi Sugiyama; Daita Kaneda; Yoshio Hashizume; Hiroyasu Akatsu; Kunio Miki; Akiko Kita; Douglas G. Walker; Kazuhiro Irie; Ikuo Tooyama
ACS Chemical Neuroscience, 31 Aug. 2021, Refereed, Lead, URL

APOE ε4 allele advances the age-dependent decline of amyloid β clearance in the human cortex
Atsushi Saito; Yusuke Kageyama; Olga Pletnikova; Gay L. Rudow; Yang An; Yumi Irie; Akiko Kita; Kunio Miki; Ling Li; Pamela Southall; Kazuhiro Irie; Juan C. Troncoso
08 Apr. 2021, URL

Diffeomorphic Registration With Intensity Transformation and Missing Data: Application to 3D Digital Pathology of Alzheimer's Disease.
Daniel Tward, Timothy Brown, Yusuke Kageyama, Jaymin Patel, Zhipeng Hou, Susumu Mori, Marilyn Albert, Juan Troncoso, Michael Miller
Frontiers in neuroscience, 11 Feb. 2020, Refereed

Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease.
W Robert Bell, Yang An, Yusuke Kageyama, Collin English, Gay L Rudow, Olga Pletnikova, Madhav Thambisetty, Richard O'Brien, Abhay R Moghekar, Marilyn S Albert, Peter V Rabins, Susan M Resnick, Juan C Troncoso
Alzheimer's & dementia : the journal of the Alzheimer's Association, 11 Dec. 2018, Refereed

Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques
Yusuke Kageyama; Atsushi Saito; Olga Pletnikova; Gay L. Rudow; Yumi Irie; Yang An; Kazuma Murakami; Kazuhiro Irie; Susan M. Resnick; David R. Fowler; Lee J. Martin; Juan C. Troncoso
Scientific Reports, 15 Nov. 2018, Refereed, Lead

The spectrum of preclinical Alzheimer's disease pathology and its modulation by ApoE genotype
Olga Pletnikova; Yusuke Kageyama; Gay Rudow; Katherine D. LaClair; Marilyn Albert; Barbara J. Crain; Jing Tian; David Fowler; Juan C. Troncoso
Neurobiology of Aging, Nov. 2018, Refereed

DISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders
Yan Jouroukhin; Yusuke Kageyama; Varvara Misheneva; Alexey Shevelkin; Shaida Andrabi; Emese Prandovszky; Robert H. Yolken; Valina L. Dawson; Ted M. Dawson; Susan Aja; Hiromi Sesaki; Mikhail V. Pletnikov
Translational Psychiatry, 12 Apr. 2018, Refereed

Localization of palmitoylated and activated G protein α‐subunit in Dictyostelium discoideum
Sarah Alamer; Yusuke Kageyama; Robert E. Gundersen
Journal of Cellular Biochemistry, 26 Feb. 2018, Refereed

Cryptic exon incorporation occurs in Alzheimer’s brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43
Mingkuan Sun; William Bell; Katherine D. LaClair; Jonathan P. Ling; Heather Han; Yusuke Kageyama; Olga Pletnikova; Juan C. Troncoso; Philip C. Wong; Liam L. Chen
Acta Neuropathologica, 22 Mar. 2017, Refereed

Elucidation of White Matter Tracts of the Human Amygdala by Detailed Comparison between High-Resolution Postmortem Magnetic Resonance Imaging and Histology
Susumu Mori; Yusuke Kageyama; Zhipeng Hou; Manisha Aggarwal; Jaymin Patel; Timothy Brown; Michael I. Miller; Dan Wu; Juan C. Troncoso
Frontiers in Neuroanatomy, 14 Mar. 2017, Refereed

B₀‐orientation dependent magnetic susceptibility‐induced white matter contrast in the human brainstem at 11.7T
Manisha Aggarwal; Yusuke Kageyama; Xu Li; Peter C. van Zijl
Magnetic Resonance in Medicine, 28 Mar. 2016, Refereed

CHCHD 10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis
Emmanuelle C Genin; Morgane Plutino; Sylvie Bannwarth; Elodie Villa; Eugenia Cisneros‐Barroso; Madhuparna Roy; Bernardo Ortega‐Vila; Konstantina Fragaki; Françoise Lespinasse; Estefania Pinero‐Martos; Gaëlle Augé; David Moore; Florence Burté; Sandra Lacas‐Gervais; Yusuke Kageyama; Kie Itoh; Patrick Yu‐Wai‐Man; Hiromi Sesaki; Jean‐Ehrland Ricci; Cristofol Vives‐Bauza; Véronique Paquis‐Flucklinger
EMBO Molecular Medicine, 14 Dec. 2015, Refereed

PARK2/Parkin becomes critical when DNM1L/Drp1 is absent
Madhuparna Roy; Yusuke Kageyama; Miho Iijima; Hiromi Sesaki
Autophagy, 25 Feb. 2015, Refereed

Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors
Madhavika N. Serasinghe; Shira Y. Wieder; Thibaud T. Renault; Rana Elkholi; James J. Asciolla; Jonathon L. Yao; Omar Jabado; Kyle Hoehn; Yusuke Kageyama; Hiromi Sesaki; Jerry E. Chipuk
Molecular Cell, Feb. 2015, Refereed

Parkin‐independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain
Yusuke Kageyama; Masahiko Hoshijima; Kinya Seo; Djahida Bedja; Polina Sysa‐Shah; Shaida A Andrabi; Weiran Chen; Ahmet Höke; Valina L Dawson; Ted M Dawson; Kathleen Gabrielson; David A Kass; Miho Iijima; Hiromi Sesaki
The EMBO Journal, 27 Oct. 2014, Refereed, Lead

In vivo functions of Drp1: Lessons learned from yeast genetics and mouse knockouts
Hiromi Sesaki; Yoshihiro Adachi; Yusuke Kageyama; Kie Itoh; Miho Iijima
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Aug. 2014

A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement
Sylvie Bannwarth; Samira Ait-El-Mkadem; Annabelle Chaussenot; Emmanuelle C. Genin; Sandra Lacas-Gervais; Konstantina Fragaki; Laetitia Berg-Alonso; Yusuke Kageyama; Valérie Serre; David G. Moore; Annie Verschueren; Cécile Rouzier; Isabelle Le Ber; Gaëlle Augé; Charlotte Cochaud; Françoise Lespinasse; Karine N’Guyen; Anne de Septenville; Alexis Brice; Patrick Yu-Wai-Man; Hiromi Sesaki; Jean Pouget; Véronique Paquis-Flucklinger
Brain, 13 Jun. 2014, Refereed

Mitochondrial division prevents neurodegeneration
Zhongyan Zhang; Yusuke Kageyama; Hiromi Sesaki
Autophagy, 16 Oct. 2012

Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies
Maria Manczak; Hiromi Sesaki; Yusuke Kageyama; P. Hemachandra Reddy
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Jun. 2012, Refereed

Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage
Yusuke Kageyama; Zhongyan Zhang; Ricardo Roda; Masahiro Fukaya; Junko Wakabayashi; Nobunao Wakabayashi; Thomas W. Kensler; P. Hemachandra Reddy; Miho Iijima; Hiromi Sesaki
Journal of Cell Biology, 07 May 2012, Refereed, Lead

Mitochondrial division: molecular machinery and physiological functions
Yusuke Kageyama; Zhongyan Zhang; Hiromi Sesaki
Current Opinion in Cell Biology, Aug. 2011

Aβ42 Analogs Fixed Indirectly in the Toxic Conformation Exist as Metastable Oligomers and are Cytotoxic at Physiological Concentrations
Yusuke Kageyama; Yumi Irie; Atsuya Matsui; Ryo C. Yanagita; Kaneyasu Nishimura; Kazuyuki Takata; Yutaka Mera; Chihiro Tsukano; Ryoji Kushima; Ikuo Tooyama; Kazuhiro Irie
The 55th Naito Conference, 01 Jul. 2026, Not invited

ヒト脳パラフィン切片における蛍光二重染色画像解析プロトコルの開発
細井克馬; 加藤遼; 入江由美; 仲山 貴永; 金田大太; 橋詰 良夫; 入江一浩; 九嶋 亮治; 景山 裕介
第67回日本神経病理学会総会学術研究会, 27 Jun. 2026, Not invited

Dynamic regional distribution of Aβ42 Type II Fibrils Identified by the TxCo-1 Antibody in Preclinical and MCI brains
Haruka Kato; Katsuma Hosoi; Yumi Irie; Yuka Matsushima; Akiko Kita; Tatsuya Segawa; Masahiro Idsutu; Naoko Taniura; Takahisa Nakayama; Daita Kaneda; Yoshio Hashizume; Ikuo Tooyama; Ryoji Kushima; Kazuhiro Irie; Yusuke Kageyama
The 67th Annual Meeting of the Japanese Society of Neuropathology, 25 Jun. 2026, Not invited

Full Digitalization of Pathology Using Whole Slide Imaging in a Regional University Hospital
Yusuke Kageyama; Yosuke Kadota; Kenji Isogawa; Katsuma Hosoi; Yuji Hayasi; Takashi Ashihara; Ryoji Kushima
The 115th Annual Meeting of the Japanese Society of Pathology, 16 Apr. 2026, Not invited

Development of conformation specific anti- Aβ42 antibody
Yusuke Kageyama
2025 年度 医学研究セミナー 大阪公立大学, 16 Jan. 2026, Invited

Atomic-Force-Microscopy-Based Prediction of the Sizes of Amyloid-β Oligomers Using Dimer Models Linked at Two Positions as Standards
Naruse, Nobuyasu; Matsui, Atsuya; Harada, Chikara; Irie,Yumi; Chikugo, Ayaka; Fujii, Kotaro; Hosoi, Katsuma; Nakanishi, Akio; Kageyama, Yusuke; Tsukano, Chihiro; Irie, Kazuhiro; Mera, Yutaka
Pacifichem 2025, 17 Dec. 2025, Not invited

アミロイドβ40の分子間2点架橋2量体モデルを用いたAFM計測おける基準値の作成
松井温哉; 原田 力; 入江由美; 内野歩美; 筑後文馨; 藤井洸太朗; 細井克馬; 中西章夫; 景山裕介; 成瀬延康; 塚野千尋; 入江一浩; 目良 裕
第67回天然有機化合物討論会, 10 Sep. 2025, Not invited

分子内SS結合により毒性配座に間接固定したAβ42誘導体の構造機能解析
景山裕介; 入江由美; 松井温哉; 柳田 亮; 西村周泰; 高田和幸; 目良 裕; 塚野千尋; 九嶋亮治; 遠山育夫; 入江一浩
第67回天然有機化合物討論会, 09 Sep. 2025, Not invited

家族性アルツハイマー病の遺伝子変異から考える抗アミロイドβ抗体の展望と課題 ― 毒性アミロイドβ42の立体構造に立脚した抗体開発 ―
景山裕介
第8回ゲノム医療研修会 滋賀県立総合病院, 24 Jun. 2025, Invited

TxCo-1 antibody recognizing the toxic conformation of aggregation-prone Aβ presents unique immunohistological patterns
Rara Fukui; Uswah Hafizal; Yusuke Kageyama; Yumi Irie; Katsuma Hosoi; Takahisa Nakayama; Daita Kaneda; Yoshio Hashizume; Kunio Miki; Akiko Kita; Ken-ichi Mukaisho; Ryoji Kushima; Ikuo Tooyama; Kazuhiro Irie
The 66th Annual Meeting of the Japanese Society of Neuropathology, 05 Jun. 2025, Not invited

Aβ42 fixed in the toxic conformation exist as metastable oligomers and are cytotoxic at physiological concentrations
Yusuke Kageyama; Yumi Irie; Atsuya Matsui; Ryo C Yanagita; Kaneyasu Nishimura; Kazuyuki Takata; Yutaka Mera; Chihiro Tsukano; Ryoji Kushima; Ikuo Tooyama; Kazuhiro Irie
The 66th Annual Meeting of the Japanese Society of Neuropathology, 05 Jun. 2025, Not invited

2点架橋したAβ 2量体を基準としたAFMによるオリゴマーの構造解析
原田 力; 松井 温哉; 入江 由美; 内野 歩美; 筑後 文馨; 藤井 洸太朗; 細井 克馬; 中西 章夫; 景山 裕介; 成瀬 延康; 塚野 千尋; 入江 一浩; 目良 裕
第72回応用物理学会春季学術講演会, 14 Mar. 2025, Not invited

分子内ジスルフィド結合形成によるアミロイドβ42 の配座固定誘導体の構造−機能解析と 抗毒性配座特異抗体の開発
松島由佳; 入江由美; 景山裕介; 遠山育夫; 喜田昭子; 三木邦夫; 瀬川辰也; 前田雅弘; 牧 俊人; 久米利明; 柳田 亮; 入江一浩
第66回天然有機化合物討論会, Not invited

新規3次元培養を用いたL-アルギニンの上部消化管がん細胞に対する抗がんメカニズムの解明
田中えり; 谷浦直子; 向所賢一; 景山裕介; 能島舞; 仲山貴永; 九嶋亮治
第113回日本病理学会総会, 28 Mar. 2024, Not invited

A case of multuple gastric tumors in a patient with autoimmune gastritis and Lynch syndrome
Yusuke Kageyama; Hidenori Kimura; Akiko Matsubara; Akira Ando; Ryoji Kushima
第113回日本病理学会総会, 28 Mar. 2024, Not invited

毒性アミロイドβの立体構造に立脚した抗体開発
景山裕介; 入江由美; 松島由佳; 瀬川辰也; 喜田昭子; 赤津裕康; 金田大太; 橋詰良夫; 入江一浩; 遠山育夫
第12回認知症予防学会学術集会, Sep. 2023, Invited

Structural optimization of the parallel β-sheet-type trimer models of amyloid β40
○Ayumi UCHINO; Yumi IRIE; Ayaka CHIKUGO; Chihiro TSUKANO; Takahito MAKI; Toshiaki KUME; Taiji KAWASE; Kenji HIROSE; Yusuke KAGEYAMA; Ikuo TOOYAMA; Kazuhiro IRIE
日本農芸化学会 2023年度 広島大会, 15 Mar. 2023, Not invited

ベムブロリズマブによるネフローゼ症候群・急性腎障害にリチウム中毒を続発した肺腺癌の1例
景山裕介、吉林護、岡島良奈、榮智徳、大張靖幸、石本尚美、桑形尚吾、山原康佑、佐々木裕紀、山原真子、金崎雅美、久米真司
第237回日本内科学会近畿地方会, Sep. 2022, Not invited

Development of a conformation specific antibody identifying toxic conformation of amyloid β peptide
Yusuke Kageyama
The 63rd Annual Meeting of the Japanese Society of Neuropatholog, 24 Jun. 2022, Not invited

The presence of Aβ toxic conformer in the inferior parietal cortex before Aβ plaque formation and its dynamic localization in aging
19th International Congress of Neuropathology, Sep. 2018, Not invited

Aβ has dynamic localization in the human brain before Aβ plaques form in Alzheimer’s disease
Johns Hopkins Pathology Grand Rounds, May 2017, Invited

病態発生学Ⅰ
Apr. 2026, Present, 滋賀医科大学医学

病理学
Apr. 2026, Present, 長浜バイオ大学

May 2026, Present
日本臨床細胞学会

Feb. 2026, Present
日本農芸化学会

Oct. 2023, Present
日本病理学会

May 2018, Present
日本神経病理学会

4R Tau発現ヒトiPS細胞を用いたAβオリゴマーと過剰リン酸化タウとの相互作用の解析
若手研究
滋賀医科大学
Apr. 2026, Mar. 2029

Development to ultra-early diagnosis and prevention of AD by using a specific antibody against the toxic conformation of amyloid beta
Grant-in-Aid for Scientific Research (A)
01 Apr. 2023, 31 Mar. 2026

アミロイドβオリゴマーの発生時期および過剰リン酸化タウとの相互作用の解析
若手研究
滋賀医科大学
Apr. 2023, Mar. 2026

特願2024-010920, 配座固定アミロイドβ42誘導体
入江一浩; 入江由美; 遠山育夫; 景山裕介

特願2021-059059, 抗アミロイドβモノクローナル抗体
入江一浩; 松島由佳; 入江由美; 遠山育夫; 景山裕介

第９回 滋賀医科大学 景山裕介 先生 「若手研究者のひらめき~研究医への誘い~」
国立大学医学部長会議, Feb. 2023, Internet