日本癌学会, 第4回JCA-CHAAO賞
PD-1抗体によるがん免疫治療法の発見

Targeted introduction of T cell receptor genes at the TRAC locus in cytotoxic T lymphocytes regenerated from human iPSCs by genome editing.
Dil Afroza; Koji Terada; Koyu Ito; Md Abdul Jabbar Khan; Kenta Kondo; Kana Yamasaki; Seiji Nagano; Kyoko Masuda; Hiroshi Kawamoto; Yasutoshi Agata
Biochemical and biophysical research communications, 14 May 2026

Distinct cytokines regulate gene expression and anti-tumor activity in regenerated CD8+ T cells from induced pluripotent stem cells
Kenta Kondo; Nobuhito Nitta; Koji Terada; Yusuke Sano; Mina Kumode; Seiji Nagano; Kyoko Masuda; Daisuke Okuzaki; Toru Miyake; Masaji Tani; Hiroshi Kawamoto; Yasutoshi Agata
iScience, Apr. 2026

Transduction of Batf family members provides distinct functions to mouse CD8+ T cells.
Kenta Kondo; Mina Kumode; Hiroki Satooka; Koji Terada; Yusuke Sano; Nobuhito Nitta; Daisuke Okuzaki; Kensuke Takada; Takako Hirata; Hidetaka Kosako; Akira Andoh; Makoto Murata; Yasutoshi Agata
International immunology, 17 Feb. 2026

サイトカインに着目したiPS細胞由来の再生T細胞の抗腫瘍活性の検討
新田 信人; 近藤 健太; 寺田 晃士; 永野 誠治; 三宅 亨; 谷 眞至; 河本 宏; 縣 保年
日本がん免疫学会総会・日本バイオセラピィ学会学術集会総会合同大会プログラム・抄録集, Jun. 2024

基礎と臨床の融合による新時代のがん免疫療法 Batfファミリー転写因子の過剰発現がCD8+T細胞の抗腫瘍能に及ぼす影響の検討
口分田 美奈; 近藤 健太; 寺田 晃士; 村田 誠; 縣 保年
日本がん免疫学会総会・日本バイオセラピィ学会学術集会総会合同大会プログラム・抄録集, Jun. 2024

次世代シークエンス技術を応用したネオアンチゲン特異的TCR遺伝子導入養子免疫療法の開発(Development of adaptive cancer immunotherapy by NGS-based identification of neoantigen-specific T cell receptor genes)
住本 秀敏; 寺田 晃士; 縣 保年; 村田 聡; 醍醐 弥太郎
日本癌学会総会記事, Sep. 2023

Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model.
Koji Terada; Kenta Kondo; Hirohito Ishigaki; Ayaka Nagashima; Hiroki Satooka; Seiji Nagano; Kyoko Masuda; Teruhisa Kawamura; Takako Hirata; Kazumasa Ogasawara; Yasushi Itoh; Hiroshi Kawamoto; Yasutoshi Agata
Molecular therapy oncolytics, 17 Mar. 2022

Regeneration of Tumor-Antigen-Specific Cytotoxic T Lymphocytes from iPSCs Transduced with Exogenous TCR Genes.
Takuya Maeda; Seiji Nagano; Soki Kashima; Koji Terada; Yasutoshi Agata; Hiroshi Ichise; Manami Ohtaka; Mahito Nakanishi; Fumihiro Fujiki; Haruo Sugiyama; Toshio Kitawaki; Norimitsu Kadowaki; Akifumi Takaori-Kondo; Kyoko Masuda; Hiroshi Kawamoto
Molecular therapy. Methods & clinical development, 11 Dec. 2020

前立腺癌のSuper-enhancerを介した新規治療標的の同定
永澤 誠之; 富松 航佑; 寺田 晃士; 和田 晃典; 吉田 哲也; 影山 進; 上仁 数義; 成田 充弘; 河内 明宏; 縣 保年
日本泌尿器科学会総会, Dec. 2020

長鎖ノンコーディングRNA MANCRによる前立腺癌細胞の遊走・浸潤の制御
永澤 誠之; 和田 晃典; 影山 進; 河内 明宏; 縣 保年
日本癌学会総会記事, Oct. 2020

カニクイザルの腫瘍浸潤T細胞から腫瘍殺傷能を有するTCR遺伝子を単離する
近藤 健太; 寺田 晃士; 石垣 宏仁; 里岡 大樹; 永野 誠治; 増田 喬子; 平田 多佳子; 小笠原 一誠; 伊藤 靖; 河本 宏; 縣 保年
日本がん免疫学会総会プログラム・抄録集, Sep. 2020

Characterization of tumour-infiltrating lymphocytes in a tumour rejection cynomolgus macaque model.
Hiroki Satooka; Hirohito Ishigaki; Kagefumi Todo; Koji Terada; Yasutoshi Agata; Yasushi Itoh; Kazumasa Ogasawara; Takako Hirata
Scientific reports, 21 May 2020

Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model.
Soki Kashima; Takuya Maeda; Kyoko Masuda; Seiji Nagano; Takamitsu Inoue; Masashi Takeda; Yuka Kono; Takashi Kobayashi; Shigeyoshi Saito; Takahiro Higuchi; Hiroshi Ichise; Yuka Kobayashi; Keiko Iwaisako; Koji Terada; Yasutoshi Agata; Kazuyuki Numakura; Mitsuru Saito; Shintaro Narita; Masaki Yasukawa; Osamu Ogawa; Tomonori Habuchi; Hiroshi Kawamoto
iScience, 24 Apr. 2020, Refereed, Not invited

Long non-coding RNA MANCR is a target of BET bromodomain protein BRD4 and plays a critical role in cellular migration and invasion abilities of prostate cancer
Masayuki Nagasawa; Kosuke Tomimatsu; Koji Terada; Kenta Kondo; Kazuko Miyazaki; Masaki Miyazaki; Daisuke Motooka; Daisuke Okuzaki; Tetsuya Yoshida; Susumu Kageyama; Hiroshi Kawamoto; Akihiro Kawauchi; Yasutoshi Agata
Biochemical and Biophysical Research Communications, 2020, Refereed, Not invited

Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells.
Miyai T; Takano J; Endo TA; Kawakami E; Agata Y; Motomura Y; Kubo M; Kashima Y; Suzuki Y; Kawamoto H; Ikawa T
Genes & development, Jan. 2018, Refereed, Not invited

The identification of D-tryptophan as a bioactive substance for postembryonic ovarian development in the planarian Dugesia ryukyuensis
Kazuya Kobayashi; Takanobu Maezawa; Hiroyuki Tanaka; Hiroyuki Onuki; Yurie Horiguchi; Hiroshi Hirota; Tetsuo Ishida; Kihachiro Horiike; Yasutoshi Agata; Manabu Aoki; Motonori Hoshi; Midori Matsumoto
SCIENTIFIC REPORTS, Mar. 2017, Refereed, Not invited

Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program
Tomokatsu Ikawa; Kyoko Masuda; Takaho A. Endo; Mitsuhiro Endo; Kyoichi Isono; Yoko Koseki; Rinako Nakagawa; Kohei Kometani; Junichiro Takano; Yasutoshi Agata; Yoshimoto Katsura; Tomohiro Kurosaki; Miguel Vidal; Haruhiko Koseki; Hiroshi Kawamoto
GENES & DEVELOPMENT, Nov. 2016, Refereed, Not invited

The Effect of D-Aspartate on Spermatogenesis in Mouse Testis
Keiji Tomita; Hiroyuki Tanaka; Susumu Kageyama; Masayuki Nagasawa; Akinori Wada; Ryosuke Murai; Kenichi Kobayashi; Eiki Hanada; Yasutoshi Agata; Akihiro Kawauchi
BIOLOGY OF REPRODUCTION, Feb. 2016, Refereed, Not invited

Induced Developmental Arrest of Early Hematopoietic Progenitors Leads to the Generation of Leukocyte Stem Cells
Tomokatsu Ikawa; Kyoko Masuda; Mirelle J. A. J. Huijskens; Rumi Satoh; Kiyokazu Kakugawa; Yasutoshi Agata; Tomohiro Miyai; Wilfred T. V. Germeraad; Yoshimoto Katsura; Hiroshi Kawamoto
STEM CELL REPORTS, Nov. 2015, Refereed, Not invited

The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant T-FH cell development, thymocyte expansion, and lymphomagenesis
Masaki Miyazaki; Kazuko Miyazaki; Shuwen Chen; Vivek Chandra; Keisuke Wagatsuma; Yasutoshi Agata; Hans-Reimer Rodewald; Rintaro Saito; Aaron N. Chang; Nissi Varki; Hiroshi Kawamoto; Cornelis Murre
GENES & DEVELOPMENT, Feb. 2015, Refereed, Not invited

Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia
Keiko Doi; Takahiko Imai; Christopher Kressler; Hideo Yagita; Yasutoshi Agata; Marc Vooijs; Yoko Hamazaki; Joe Inoue; Nagahiro Minato
SCIENTIFIC REPORTS, Jan. 2015, Refereed, Not invited

Immunohistochemical localization of D-serine dehydratase in chicken tissues
Yoshihiro Nishimura; Hiroyuki Tanaka; Tetsuo Ishida; Shinji Imai; Yoshitaka Matsusue; Yasutoshi Agata; Kihachiro Horiike
ACTA HISTOCHEMICA, 2014, Refereed, Not invited

Reciprocal Control of G(1)-Phase Progression Is Required for Th-POK/Runx3-Mediated CD4/8 Thymocyte Cell Fate Decision
Takehito Sato; Tomoki Chiba; Shin-ichiro Ohno; Chiharu Sato; Tatsuya Sugoh; Keiko Miyashita; Hisako Akatsuka; Katsuto Hozumi; Yoshinori Okada; Yumi Iida; Akira Akatsuka; Yasutoshi Agata; Marin Chiba; Kazuyoshi Kohu; Masanobu Satake; Hideyuki Tanabe; Hideyuki Saya; Sonoko Habu
JOURNAL OF IMMUNOLOGY, Nov. 2012, Refereed, Not invited

High Expression of Nuclear Factor 90 (NF90) Leads to Mitochondrial Degradation in Skeletal and Cardiac Muscles
Takuma Higuchi; Shuji Sakamoto; Yoshihiko Kakinuma; Shoko Kai; Ken-ichi Yagyu; Hiroshi Todaka; Eunsup Chi; Shoshiro Okada; Takako Ujihara; Keiko Morisawa; Masafumi Ono; Yasunori Sugiyama; Waka Ishida; Atsuki Fukushima; Masayuki Tsuda; Yasutoshi Agata; Taketoshi Taniguchi
PLOS ONE, Aug. 2012, Refereed, Not invited

E2A and CBP/p300 Act in Synergy To Promote Chromatin Accessibility of the Immunoglobulin kappa Locus
Shuji Sakamoto; Kousho Wakae; Yuki Anzai; Kiyohito Murai; Nobuyuki Tamaki; Masaki Miyazaki; Kazuko Miyazaki; William J. Romanow; Tomokatsu Ikawa; Daisuke Kitamura; Itaru Yanagihara; Nagahiro Minato; Cornelis Murre; Yasutoshi Agata
JOURNAL OF IMMUNOLOGY, Jun. 2012, Refereed, Not invited

Imatinib mesylate directly impairs class switch recombination through down-regulation of AID: its potential efficacy as an AID suppressor.
Kawamata Toyotaka; Lu Jun; Sato Tadayuki; Tanaka Masafumi; Nagaoka Hitoshi; Agata Yasutoshi; Toyoshima Takae; Yokoyama Kazuaki; Oyaizu Naoki; Nakamura Naoya; Ando Kiyoshi; Tojo Arinobu; Kotani Ai
Blood, Mar. 2012, Refereed, Not invited

Imatinib mesylate directly impairs class switch recombination through down-regulation of AID: its potential efficacy as an AID suppressor
Toyotaka Kawamata; Jun Lu; Tadayuki Sato; Masafumi Tanaka; Hitoshi Nagaoka; Yasutoshi Agata; Takae Toyoshima; Kazuaki Yokoyama; Naoki Oyaizu; Naoya Nakamura; Kiyoshi Ando; Arinobu Tojo; Ai Kotani
BLOOD, Mar. 2012, Refereed, Not invited

The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells
Masaki Miyazaki; Richard R. Rivera; Kazuko Miyazaki; Yin C. Lin; Yasutoshi Agata; Cornelis Murre
NATURE IMMUNOLOGY, Oct. 2011, Refereed, Not invited

Regulation of TCR V gamma 2 gene rearrangement by the helix-loop-helix protein, E2A
Masatoshi Nozaki; Kousho Wakae; Nobuyuki Tamaki; Shuji Sakamoto; Kiyouhisa Ohnishi; Toshifumi Uejima; Nagahiro Minato; Itaru Yanagihara; Yasutoshi Agata
INTERNATIONAL IMMUNOLOGY, May 2011, Refereed, Not invited

Claudin-4 induction by E-protein activity in later stages of CD4/8 double-positive thymocytes to increase positive selection efficiency
Yohei Kawai; Yoko Hamazaki; Harumi Fujita; Akikazu Fujita; Takehito Sato; Mikio Furuse; Toyoshi Fujimoto; Anton M. Jetten; Yasutoshi Agata; Nagahiro Minato
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2011, Refereed, Not invited

The NF90-NF45 Complex Functions as a Negative Regulator in the MicroRNA Processing Pathway
Shuji Sakamoto; Kazuma Aoki; Takuma Higuchi; Hiroshi Todaka; Keiko Morisawa; Nobuyuki Tamaki; Etsuro Hatano; Atsuki Fukushima; Taketoshi Taniguchi; Yasutoshi Agata
MOLECULAR AND CELLULAR BIOLOGY, Jul. 2009, Refereed, Not invited

Regulation of histone H4 acetylation by transcription factor E2A in Ig gene conversion
Hiroyuki Kitao; Masayo Kimura; Kazuhiko Yamamoto; Hidetaka Seo; Keiko Namikoshi; Yasutoshi Agata; Kunihiro Ohta; Minoru Takata
INTERNATIONAL IMMUNOLOGY, Feb. 2008, Refereed, Not invited

Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47
Yasutoshi Agata; Nobuyuki Tamaki; Shuji Sakamoto; Tomokatsu Ikawa; Kyoko Masuda; Hiroshi Kawamoto; Cornelis Murre
IMMUNITY, Dec. 2007, Refereed, Not invited

Spontaneous large-scale lymphoid neogenesis and balanced autoimmunity versus tolerance in the stomach of H+/K+-ATPase-Reactive TCR transgenic mouse
Tomoya Katakai; Takashi Nomura; Hiroyuki Gonda; Manabu Sugai; Yasutoshi Agata; Akiyoshi Nishio; Tohru Masuda; Shimon Sakaguchi; Akira Shimizu
JOURNAL OF IMMUNOLOGY, Dec. 2006, Refereed, Not invited

[Chromatin dynamics in gene rearrangement].
Agata Y
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Apr. 2006, Refereed, Not invited

Direct interaction of NRSF with TBP: chromatin reorganization and core promoter repression for neuron-specific gene transcription
K Murai; Y Naruse; Y Shaul; Y Agata; N Mori
NUCLEIC ACIDS RESEARCH, Jun. 2004, Refereed, Not invited

Transcription-coupled events associating with immunoglobulin switch region chromatin
Y Nambu; M Sugai; H Gonda; CG Lee; T Katakai; Y Agata; Y Yokota; A Shimizu
SCIENCE, Dec. 2003, Refereed, Not invited

The balance between Pax5 and Id2 activities is the key to AID gene expression
H Gonda; M Sugai; Y Nambu; T Katakai; Y Agata; KJ Mori; Y Yokota; A Shimizu
JOURNAL OF EXPERIMENTAL MEDICINE, Nov. 2003, Refereed, Not invited

E-proteins directly regulate expression of activation-induced deaminase in mature B cells
CE Sayegh; MW Quong; Y Agata; C Murre
NATURE IMMUNOLOGY, Jun. 2003, Refereed, Not invited

Chemokine-independent preference for T-helper-1 cells in transendothelial migration
T Katakai; T Hara; M Sugai; H Gonda; Y Nambu; E Matsuda; Y Agata; A Shimizu
JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2002, Refereed, Not invited

Histone acetylation determines the developmentally regulated accessibility for T cell receptor γ gene recombination
Y. Agata; T. Katakai; S.-K. Ye; M. Sugai; H. Gonda; T. Honjo; K. Ikuta; A. Shimizu
Journal of Experimental Medicine, Apr. 2001, Refereed, Not invited

Targeting of Krüppel-associated box-containing zinc finger proteins to centromeric heterochromatin. Implication for the gene silencing mechanisms.
Matsuda E; Agata Y; Sugai M; Katakai T; Gonda H; Shimizu A
The Journal of biological chemistry, Apr. 2001, Refereed, Not invited

The IL-7 receptor controls the accessibility of the TCRγ locus by Stat5 and histone acetylation
S.-K. Ye; Y. Agata; H.-C. Lee; H. Kurooka; T. Kitamura; A. Shimizu; T. Honjo; K. Ikuta
Immunity, 2001, Refereed, Not invited

Two novel Kruppel-associated box-containing zinc-finger proteins, KRAZ1 and KRAZ2, repress transcription through functional interaction with the corepressor KAP-1 (TIF1 beta/KRIP-1)
Y Agata; E Matsuda; A Shimizu
JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 1999, Not refereed, Not invited

Rapid and efficient cloning of cDNAs encoding Kruppel-like zinc finger proteins by degenerate PCR
Y Agata; E Matsuda; A Shimizu
GENE, Jun. 1998, Not refereed, Not invited

Structure of the TCR expressed on a gastritogenic T cell clone, II-6, and frequent appearance of similar clonotypes in mice bearing autoimmune gastritis
T Katakai; Y Agata; A Shimizu; C Ohshima; A Nishio; M Inaba; S Kasakura; KJ Mori; T Masuda
INTERNATIONAL IMMUNOLOGY, Dec. 1997, Not refereed, Not invited

Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4(-)CD8(-)) thymocytes
H Nishimura; Y Agata; A Kawasaki; M Sato; S Imamura; N Minato; H Yagita; T Nakano; T Honjo
INTERNATIONAL IMMUNOLOGY, May 1996, Not refereed, Not invited

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
Y Agata; A Kawasaki; H Nishimura; Y Ishida; T Tsubata; H Yagita; T Honjo
INTERNATIONAL IMMUNOLOGY, May 1996, Not refereed, Not invited

INDUCED EXPRESSION OF PD-1, A NOVEL MEMBER OF THE IMMUNOGLOBULIN GENE SUPERFAMILY, UPON PROGRAMMED CELL-DEATH
Y ISHIDA; Y AGATA; K SHIBAHARA; T HONJO
EMBO JOURNAL, Nov. 1992, Not refereed, Not invited

Prevention of NK cell-mediated reaction against HLA-KO cells by using membrane bound mAbs for inhibitory NK receptors
Masao Itahara; Kyoko Masuda; Koji Terada; Yuma Kato; Yasutoshi Agata; Hisashi Arase; Hiroshi Kawamoto
CANCER SCIENCE, Jan. 2026

次世代シークエンス技術を応用したネオアンチゲン特異的TCR遺伝子導入養子免疫療法の開発(Development of adaptive cancer immunotherapy by NGS-based identification of neoantigen-specific T cell receptor genes)
住本 秀敏; 寺田 晃士; 縣 保年; 村田 聡; 醍醐 弥太郎
日本癌学会総会記事, Sep. 2023

TCR遺伝子導入iPS細胞からCTLを再生するための新規の方法:TCRカセット法の開発
永野誠治; 寺田晃士; 前田卓也; 嘉島相輝; 縣保年; 増田喬子; 河本宏
日本がん免疫学会総会プログラム・抄録集, 2020

D型アスパラギン酸が精子形成に及ぼす影響の検討
富田 圭司; 村井 亮介; 花田 英紀; 影山 進; 成田 充弘; 河内 明宏; 田中 裕之; 縣 保年
日本泌尿器科学会総会, Apr. 2015, Not refereed, Not invited

The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells (vol 12, pg 992, 2011)
Masaki Miyazaki; Richard R. Rivera; Kazuko Miyazaki; Yin C. Lin; Yasutoshi Agata; Cornelis Murre
NATURE IMMUNOLOGY, Apr. 2013, Not refereed, Not invited

細胞接着・細胞外基質・細胞間相互作用 E-proteinによる胸腺内T細胞におけるクローディンの発現誘導とそのT細胞受容体シグナルにおける役割(Cell adhesion/ ECM/ Cell-cell interaction Claudin-4 induction by E-protein activity in thymic lymphocytes and its role in the TCR-mediated signaling)
藤田 春美; 河合 洋平; 藤田 秋一; 藤本 豊士; 古瀬 幹夫; 縣 保年; 湊 長博; 濱崎 洋子
日本細胞生物学会大会講演要旨集, May 2011

Claudin-4 is induced in thymocytes of late CD4/CD8 double positive stage by E2A and promotes abT cell receptor–mediated positive selection.
Kawai. K; Hamazaki, Y; Fujita, H; Fujita, A; Sato, T; Moriwaki, K; Furuse, M; Fujimoto, T; Agata, Y; Minato, N
Proc. Nat. Acad. Sci. USA. 108(10):4075-4080., 2011, Refereed, Not invited

二本鎖RNA結合蛋白質NF90-NF45によるmiRNA生合成経路における負の制御
坂本修士; 樋口琢磨; 戸高寛; 森澤啓子; 青木一真; 青木一真; 谷口武利; 縣保年
日本RNA学会年会要旨集, 2009

miRNA生合成におけるNF90family-NF45の役割及び肝細胞癌における発現解析
坂本修士; 森澤啓子; 樋口琢磨; 戸高寛; 甲斐翔子; OBATA Eunsup; 玉置信行; 波多野悦郎; 縣保年; 谷口武利
生化学, 2008

遺伝子再編成におけるクロマチンのダイナミクス (特集 細胞核とクロマチン--ヒストンコードを超えて)
縣 保年
蛋白質核酸酵素, Apr. 2006

転写因子によるTCR Vγ遺伝子の組換え制御機構
谷一靖江; 縣保年; 生田宏一
日本免疫学会総会・学術集会記録, 2006

ヒストンのアセチル化による抗原レセプター遺伝子組換え制御
縣 保年; 生田 宏一
臨床免疫, Dec. 2001

免疫組織 IL-7レセプターシグナルによるTCRγ遺伝子座の組換え制御
生田 宏一; ぜい 相奎; 李 海天; 縣 保年
Annual Review免疫, Dec. 2001

【クロマチン修飾と構造変換】クロマチン修飾とリモデリングによる抗原レセプター遺伝子組換え制御
縣 保年; 生田 宏一
実験医学, Oct. 2001

Stat5と転写共役因子によるT細胞レセプターγ遺伝子座の組換え制御機構
YE S-K; 県保年; 李海天; 北村俊雄; 清水章; 生田宏一
生化学, 2001

ヒストンアセチル化によるTCRγ遺伝子V-J組換えの制御機構
縣 保年; 片貝 智哉; Ye Sang-Kyu; 生田 宏一; 清水 章
日本免疫学会総会・学術集会記録, Nov. 2000, Not refereed, Not invited

KRABを持つ新しいZnフィンガー因子KRAZ1とKRAZ2のcorepressor因子KAP-1を介する転写抑制メカニズム
松田 永照; 縣 保年; 清水 章
生化学, Aug. 1999

Transcriptional repression by novel KRAB-containing zinc finger proteins, Mszf42/49, through the interaction with a corepressor, KAP-1
AGATA Yasutoshi; MATSUDA Eishou; SHIMIZU Akira
日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998, Not refereed, Not invited

日本免疫学会

日本分子生物学会

日本生化学会

Development of cancer immunotherapy using T cells regenerated from iPS cells and cynomolgus macaque cancer models
Grant-in-Aid for Scientific Research (B)
Shiga University of Medical Science
01 Apr. 2024, 31 Mar. 2027

Development of cancer immunotherapy using T cells regenerated from iPS cells and genetically modified cynomolgus macaque
Grant-in-Aid for Scientific Research (B)
Shiga University of Medical Science
01 Apr. 2021, 31 Mar. 2024

Development of cancer immunotherapy using T cells regenerated from iPS cells and genetically engineered monkeys
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
01 Apr. 2018, 31 Mar. 2022

Efficient regeneration of tumor-specific cytotoxic lymphocytes using the iPSC technology and genome editing
Grant-in-Aid for Challenging Exploratory Research
Shiga University of Medical Science
01 Apr. 2016, 31 Mar. 2019

Purification of the functional transcription factor complex and analyses of the factors that constitute the complex
Grant-in-Aid for Challenging Exploratory Research
Shiga University of Medical Science
01 Apr. 2014, 31 Mar. 2017

Novel epigenetic regulation of the gene expression program by chromosome dynamics
Grant-in-Aid for Scientific Research (B)
01 Apr. 2011, 31 Mar. 2015

コヒーシンによる染色体構造変化を介した造血細胞分化の制御機構
新学術領域研究(研究領域提案型)
01 Apr. 2011, 31 Mar. 2013

抗原受容体遺伝子の対立遺伝子排除による自己形成の分子基盤
特定領域研究
京都大学
2010, 2012

Regulatory mechanisms of allelic exclusion by epigenetics and chromosome dynamics
Grant-in-Aid for Scientific Research (C)
Kyoto University
2008, 2010

TCR遺伝子の対立遺伝子排除による自己形成の分子基盤
特定領域研究
京都大学
2008, 2009

Elucidation of the epigenetic regulation of the antigen receptor gene rearrangement
Grant-in-Aid for Scientific Research (C)
Kyoto University
2005, 2006

体細胞突然変異の遺伝子部位特異的な導入機構
特定領域研究
京都大学
2004, 2005

Znフィンガー因子の系統的遺伝子単離と転写調節における機能の解析
奨励研究(A)
京都大学
1997, 1998

B細胞の分化初期に発現するZnフィンガー因子の遺伝子単離と解析
奨励研究(A)
京都大学
1996, 1996

Regulation of RNA processing in B lymphocyte differentiation
Grant-in-Aid for international Scientific Research
KYOTO UNIVERSITY
1995, 1996

B細胞の初期分化を制御するZnフィンガー因子の遺伝子単離と解析
奨励研究(A)
京都大学
1995, 1995

Znフィンガー転写因子の転写抑制機構の解析

Znフィンガー因子の遺伝子単離

Molecular analysis of the transcriptional repression mediated by Zn finger protein

Molecular cloning of Zn finger factor genes