Slc22a23 Proficiency Influences Rat Behavioral Responses After Lysophosphatidylcholine C20:4n6 Administration.
Yasuhiro Uchimura; Masakazu Shinohara; Shuhei Kikuchi; Yoshinori Kubo; Shiori Nagaike; Tomoko Kimura; Kosuke Hattori; Tomoji Mashimo; Jun Udagawa
Pharmaceutics, 08 Aug. 2026

Ethanolamine and Vinyl–Ether Moieties in Brain Phospholipids Modulate Behavior in Rats
MST Zenika Nasrin; Shuhei Kikuchi; Yasuhiro Uchimura; Mina Yoshioka; Shin-ya Morita; Tomoya Kobayashi; Yusuke Kinoshita; Yoshio Furusho; Hitoshi Tamiaki; Daijiro Yanagisawa; Jun Udagawa
NeuroSci, 04 Nov. 2024

Knockout of the orphan membrane transporter Slc22a23 leads to a lean and hyperactive phenotype with a small hippocampal volume
Yasuhiro Uchimura; Kodai Hino; Kosuke Hattori; Yoshinori Kubo; Airi Owada; Tomoko Kimura; Lucia Sugawara; Shinji Kume; Jean-Pierre Bellier; Daijiro Yanagisawa; Akihiko Shiino; Takahisa Nakayama; Yataro Daigo; Tomoji Mashimo; Jun Udagawa
PLOS ONE, 28 Aug. 2024

Solitary and Synergistic Effects of Different Hydrophilic and Hydrophobic Phospholipid Moieties on Rat Behaviors
Shuhei Kikuchi; Yugo Iwasaki; Mina Yoshioka; Kodai Hino; Shin-ya Morita; Ryu Tada; Yasuhiro Uchimura; Yoshinori Kubo; Tomoya Kobayashi; Yusuke Kinoshita; Masahiro Hayashi; Yoshio Furusho; Hitoshi Tamiaki; Hiroaki Ishiyama; Minoru Kuroda; Jun Udagawa
Pharmaceutics, 04 Jun. 2024

Excessive folic acid intake combined with undernutrition during gestation alters offspring behavior and brain monoamine profiles.
Tetsuo Ono; Kodai Hino; Tomoko Kimura; Yasuhiro Uchimura; Takashi Ashihara; Takako Higa; Hideto Kojima; Takashi Murakami; Jun Udagawa
Congenital anomalies, 09 May 2022

Global pattern of interkinetic nuclear migration in tracheoesophageal epithelia of the mouse embryo: Interorgan and intraorgan regional differences.
Dereje Getachew; Akihiro Matsumoto; Yasuhiro Uchimura; Jun Udagawa; Nanako Mita; Noriko Ogawa; Shigeru Moriyama; Akiyasu Takami; Hiroki Otani
Congenital anomalies, 29 Nov. 2020

Postweaning Iron Deficiency in Male Rats Leads to Long-Term Hyperactivity and Decreased Reelin Gene Expression in the Nucleus Accumbens.
Noriko Nishikura; Kodai Hino; Tomoko Kimura; Yasuhiro Uchimura; Shinjiro Hino; Mitsuyoshi Nakao; Yoshihiro Maruo; Jun Udagawa
The Journal of nutrition, 01 Feb. 2020, Refereed, Not invited

Correlation between musculoskeletal structure of the hand and primate locomotion: Morphometric and mechanical analysis in prehension using the cross- and triple-ratios.
Toshihiro Tamagawa; Torbjörn Lundh; Kenji Shigetoshi; Norihisa Nitta; Noritoshi Ushio; Toshiro Inubushi; Akihiko Shiino; Anders Karlsson; Takayuki Inoue; Yutaka Mera; Kodai Hino; Masaru Komori; Shigehiro Morikawa; Shuji Sawajiri; Shigeyuki Naka; Satoru Honma; Tomoko Kimura; Yasuhiro Uchimura; Shinji Imai; Naoko Egi; Hiroki Otani; Jun Udagawa
PloS one, 2020, Refereed, Not invited

Antibodies Set Boundaries Limiting Microbial Metabolite Penetration and the Resultant Mammalian Host Response.
Yasuhiro Uchimura; Tobias Fuhrer; Hai Li; Melissa A Lawson; Michael Zimmermann; Bahtiyar Yilmaz; Joel Zindel; Francesca Ronchi; Marcel Sorribas; Siegfried Hapfelmeier; Stephanie C Ganal-Vonarburg; Mercedes Gomez de Agüero; Kathy D McCoy; Uwe Sauer; Andrew J Macpherson
Immunity, 18 Sep. 2018, Refereed, Not invited

Complete Genome Sequences of 12 Species of Stable Defined Moderately Diverse Mouse Microbiota 2.
Yasuhiro Uchimura; Madeleine Wyss; Sandrine Brugiroux; Julien P Limenitakis; Bärbel Stecher; Kathy D McCoy; Andrew J Macpherson
Genome announcements, 15 Sep. 2016, Refereed, Not invited

The maternal microbiota drives early postnatal innate immune development.
Mercedes Gomez de Agüero; Stephanie C Ganal-Vonarburg; Tobias Fuhrer; Sandra Rupp; Yasuhiro Uchimura; Hai Li; Anna Steinert; Mathias Heikenwalder; Siegfried Hapfelmeier; Uwe Sauer; Kathy D McCoy; Andrew J Macpherson
Science (New York, N.Y.), 18 Mar. 2016, Refereed, Not invited

REG-γ associates with and modulates the abundance of nuclear activation-induced deaminase.
Yasuhiro Uchimura; Lance F Barton; Cristina Rada; Michael S Neuberger
The Journal of experimental medicine, 21 Nov. 2011, Refereed, Not invited

Stimulation of DNA Glycosylase Activities by XPC Protein Complex: Roles of Protein-Protein Interactions.
Yuichiro Shimizu; Yasuhiro Uchimura; Naoshi Dohmae; Hisato Saitoh; Fumio Hanaoka; Kaoru Sugasawa
Journal of nucleic acids, 25 Jul. 2010, Refereed, Not invited

The p150 subunit of CAF-1 causes association of SUMO2/3 with the DNA replication foci.
Junsuke Uwada; Niina Tanaka; Yutaro Yamaguchi; Yasuhiro Uchimura; Kei-ichi Shibahara; Mitsuyoshi Nakao; Hisato Saitoh
Biochemical and biophysical research communications, 01 Jan. 2010, Refereed, Not invited

Structure of the small ubiquitin-like modifier (SUMO)-interacting motif of MBD1-containing chromatin-associated factor 1 bound to SUMO-3.
Naotaka Sekiyama; Takahisa Ikegami; Tsutomu Yamane; Mitsunori Ikeguchi; Yasuhiro Uchimura; Daichi Baba; Mariko Ariyoshi; Hidehito Tochio; Hisato Saitoh; Masahiro Shirakawa
The Journal of biological chemistry, 19 Dec. 2008, Refereed, Not invited

Noncovalent binding of small ubiquitin-related modifier (SUMO) protease to SUMO is necessary for enzymatic activities and cell growth.
Motomasa Ihara; Hirofumi Koyama; Yasuhiro Uchimura; Hisato Saitoh; Akira Kikuchi
The Journal of biological chemistry, 01 Jun. 2007, Refereed, Not invited

Inhibition of DNA binding of Sox2 by the SUMO conjugation.
Shu Tsuruzoe; Ko Ishihara; Yasuhiro Uchimura; Sugiko Watanabe; Yoko Sekita; Takahiro Aoto; Hisato Saitoh; Yasuhito Yuasa; Hitoshi Niwa; Michio Kawasuji; Hideo Baba; Mitsuyoshi Nakao
Biochemical and biophysical research communications, 29 Dec. 2006, Refereed, Not invited

Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation.
Yasuhiro Uchimura; Takaya Ichimura; Junsuke Uwada; Taro Tachibana; Satoko Sugahara; Mitsuyoshi Nakao; Hisato Saitoh
The Journal of biological chemistry, 11 Aug. 2006, Refereed, Not invited

[Studying the SUMO modification pathway: from molecular structure to regulation of epigenome].
Hisato Saitoh; Yasuhiro Uchimura; Tsuyoshi Mishiro; Junsuke Uwada
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Aug. 2006, Refereed, Not invited

MafG sumoylation is required for active transcriptional repression.
Hozumi Motohashi; Fumiki Katsuoka; Chika Miyoshi; Yasuhiro Uchimura; Hisato Saitoh; Claire Francastel; James Douglas Engel; Masayuki Yamamoto
Molecular and cellular biology, Jun. 2006, Refereed, Not invited

Crystal structure of SUMO-3-modified thymine-DNA glycosylase.
Daichi Baba; Nobuo Maita; Jun-Goo Jee; Yasuhiro Uchimura; Hisato Saitoh; Kaoru Sugasawa; Fumio Hanaoka; Hidehito Tochio; Hidekazu Hiroaki; Masahiro Shirakawa
Journal of molecular biology, 26 May 2006, Refereed, Not invited

In situ SUMOylation analysis reveals a modulatory role of RanBP2 in the nuclear rim and PML bodies.
Noriko Saitoh; Yasuhiro Uchimura; Taro Tachibana; Satoko Sugahara; Hisato Saitoh; Mitsuyoshi Nakao
Experimental cell research, 01 May 2006, Refereed, Not invited

転写因子OCT3/4のSUMO化制御
Tsuruzoe S; Ichihara K; Uchimura Y; Watanabe S; Sekita Y; Aoto T; Saitoh H; Yuasa Y; Niwa H; Kawasuji M; Baba H; Nakao M
Biochem. Biophys. Res. Commun., 2006, Not refereed, Not invited

Crystal structure of thymine DNA glycosylase conjugated to SUMO-1.
Daichi Baba; Nobuo Maita; Jun-Goo Jee; Yasuhiro Uchimura; Hisato Saitoh; Kaoru Sugasawa; Fumio Hanaoka; Hidehito Tochio; Hidekazu Hiroaki; Masahiro Shirakawa
Nature, 16 Jun. 2005, Refereed, Not invited

Overproduction of eukaryotic SUMO-1- and SUMO-2-conjugated proteins in Escherichia coli.
Yasuhiro Uchimura; Makoto Nakamura; Kaoru Sugasawa; Mitsuyoshi Nakao; Hisato Saitoh
Analytical biochemistry, 01 Aug. 2004, Refereed, Not invited

Generation of SUMO-1 modified proteins in E. coli: towards understanding the biochemistry/structural biology of the SUMO-1 pathway.
Yasuhiro Uchimura; Mitsuyoshi Nakao; Hisato Saitoh
FEBS letters, 23 Apr. 2004, Refereed, Not invited

Serum response factor is modulated by the SUMO-1 conjugation system.
Kazuhito Matsuzaki; Takeshi Minami; Masahide Tojo; Yoshiomi Honda; Yasuhiro Uchimura; Hisato Saitoh; Hideyo Yasuda; Shinji Nagahiro; Hideyuki Saya; Mitsuyoshi Nakao
Biochemical and biophysical research communications, 20 Jun. 2003, Refereed, Not invited

Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex
H Nishitani; E Hirose; Y Uchimura; M Nakamura; M Umeda; K Nishii; N Mori; T Nishimoto
GENE, Jul. 2001, Refereed, Not invited

胎生初期低栄養かつ閉経後の脂肪肝発症リスクは腸内細菌叢の変化により抑制される
黒田 実; 木村 智子; 菊池 修平; 内村 康寛; 坂本 真優; 久保 佳範; 河村 奈美子; 宇田川 潤
基礎理学療法学, 2025

胎生初期低栄養による閉経後の脂肪肝発症リスクの上昇メカニズムとその改善策の検討
黒田 実; 木村 智子; 菊池 修平; 内村 康寛; 久保 佳範; 坂本 真優; 河村 奈美子; 宇田川 潤
DOHaD研究, 13 Oct. 2024

離乳後鉄欠乏ラットの側坐核におけるReelin遺伝子発現の変化(Postweaning iron deficiency in rats alters the reelin expression in the nucleus accumbens)
西倉 紀子; 日野 広大; 木村 智子; 内村 康寛; 森宗 孝夫; 松井 潤; 底田 辰之; 澤井 ちひろ; 阪上 由子; 竹内 義博; 丸尾 良浩; 宇田川 潤
脳と発達, May 2019

Antibodies Set Boundaries Limiting Microbial Metabolite Penetration and the Resultant Mammalian Host Response.
Yasuhiro Uchimura
Clinical Immunology & Allergology, Apr. 2019, Not refereed, Invited

ユビキチン関連修飾 SUMO研究の10年--分子構造からエピゲノム制御へ (ユビキチン-プロテアソーム系とオートファジー--作動機構と病態生理) -- (ユビキチン-プロテアソーム系)
斉藤 寿仁; 内村 康寛; 三代 剛
蛋白質核酸酵素, Aug. 2006

Synthesis of protein conjugates/polymers using SUMO modification enzymes
SAITOH Hisato; UCHIMURA Yasuhiro; UWADA Junsuke; MISHIRO Tsuyoshi
Bioscience & industry, 01 Feb. 2006

1SF04 SUMOylation of a DNA repair protein
Shirakawa M.; Baba D.; Maita N.; Saito H.; Uchimura Y.; Sugasawa K.; Hanaoka F.; Tochio H.; Hiroaki H.
Seibutsu Butsuri, 2005

ユビキチンファミリーのクロストーク (第1土曜特集 ユビキチン研究の新展開--メカニズムから疾患研究へ) -- (基礎編)
内村 康寛; 斉藤 寿仁
医学のあゆみ, 02 Oct. 2004

SUMOコードの謎を解く
斎藤 寿仁; 内村 康寛; 中村 秀明; 三浦 さき子; 土山 幸美, Joint work
実験医学, 2005, Not refereed

SUMO蛋白質修飾システムとヒト疾患関連性
水流添 周; 内村 康寛; 斎藤 寿仁, Joint work
医学のあゆみ, 2004, Not refereed

ユビキチファミリーのクロストーク
内村 康寛; 斎藤 寿仁, Joint work
医学のあゆみ, 2004, Not refereed

胎生期低栄養で高発現するSlc22a23遺伝子の機能解析
内村康寛; 篠原正和; 真下知士; 宇田川潤
第14回 日本DOHaD学会学術集会, 31 Aug. 2026

胎生期低栄養で高発現するSlc22a23遺伝子の機能解析
内村康寛; 篠原正和; 真下知士; 宇田川潤
第66回日本先天異常学会学術集会, 25 Jul. 2026, Not invited

ノックアウトラットを用いた胎生期低栄養に応答するSic22a23遺伝子の機能解析
内村康寛; 篠原正和; 服部晃佑; 真下知士; 宇田川潤
2025年度 文部科学省 学術変革領域研究 学術研究支援基盤形成 先端モデル動物支援 プラットフォーム 成果発表会, 20 Feb. 2026, Not invited

A knockou;ra;model to;elucidate the molecular mechanisms underlying;he developmental origins of health;disease (DOHaD) theory
内村康寛
第19回ラットリソースリサーチ研究会, 13 Feb. 2026

Slc22a23ノックアウトラットの表現型解析
内村康寛; 篠原正和; 真下知士; 宇田川潤
第101回日本解剖学会近畿支部学術集会解剖学会, 15 Nov. 2025, Not invited

リゾリン脂質投与によるSlc22a23ノックアウトラットの行動変化
内村康寛; 篠原正和; 久保佳範; 菊池修平; 長池史織; 木村智子; 服部晃佑; 真下知士; 宇田川潤
第65回日本先天異常学会学術集会, 25 Jul. 2025, Not invited

SLC22A23輸送体の基質候補物質投与によるラットの行動変化
内村康寛; 篠原正和; 久保佳範; 菊池修平; 長池史織; 木村智子; 服部晃佑; 真下知士; 宇田川潤
2024年度 文部科学省 学術変革領域研究 学術研究支援基盤形成 先端モデル動物支援 プラットフォーム 成果発表会, 13 Feb. 2025, Not invited

Slc22a23遺伝子ノックアウトラットの作製と表現型の解析
内村康寛; 日野広大; 服部晃佑; 椎野顯彦; 久保佳範; 大和田愛理; 木村智子; 菅原礼知安; 久米真司; 仲山貴永; 醍醐弥太郎; 真下知士; 宇田川潤
2023年度 文部科学省 学術変革領域研究 学術研究支援基盤形成 先端モデル動物支援 プラットフォーム 成果発表会, 08 Feb. 2024

胎児期低栄養により高発現するSlc22a23輸送体の機能解析
内村 康寛; 小峰 愛理; 篠原 正和; 岬 沙耶香; 日野 広大; 木村 智子; 渡邉 嘉之; 宇田川 潤
第9回 日本DOHaD学会学術集会, 08 Oct. 2022, Not invited

Prenatal undernutrition increases expression of an orphan membrane transporter SLC22a23 in rat brain
Yasuhiro Uchimura
第126回 日本解剖学会総会・全国学術集会 第98回 日本生理学会大会 合同大会, 28 Mar. 2021, Not invited

系統解剖における内臓逆位の観察の一例
内村 康寛
第124回 日本解剖学会総会 全国学術集会, 27 Mar. 2019, Not invited

Antibodies set boundaries limiting microbial metabolite penetration and the resultant mammalian host response
内村 康寛
第 93 回 日本解剖学会近畿支部学術集会, 25 Nov. 2017, Not invited

Microbial host molecular transfer pathways after mucosal immune non-immune priming
Yasuhiro Uchimura
Joint Immunology meeting, Zurich, Switzerland, Nov. 2016, Not invited

13C-labeled bacterial metabolomics reveals the identity of bacterial metabolites in the host and the host metabolic responses
Yasuhiro Uchimura; Tobias Fuhrer; Uwe Sauer; Kathy D. McCoy; Andrew J. Macpherson
Schweizerische Gasellschaft für Gastroenterologie (SGG) Jahreskongress, Interlaken, Switzerland, Sep. 2016, Not invited

Metabolomics approach toward understanding mutualism between intestinal bacteria and the host
UVCM retreat, Bern, Switzerland, Jan. 2014, Not invited

Dec. 2025, Present
日本生化学会

Mar. 2025, Present
日本先天異常学会

Jun. 2017, Present
日本DOHaD学会

Jun. 2017, Present
THE JAPANESE ASSOCIATION OF ANATOMISTS

胎生初期低栄養により誘発される閉経後MASLD発症機序の解明ならびに改善策の検討
基盤研究(C)
京都橘大学
01 Apr. 2025, 31 Mar. 2028

Design of a plasmalogen with the function of the emotional control and elucidation of its transport pathway into the brain target cells.
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
01 Apr. 2020, 31 Mar. 2023

低栄養発育胎児における有機陰イオン輸送体の機能の解明
基盤研究(C)
滋賀医科大学
01 Apr. 2019, 31 Mar. 2023

Analysis of the mechanism, through which the disturbances in the behavior and the brain phospholipid composition are caused by prenatal stress to the neural stem cells.
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
01 Apr. 2016, 31 Mar. 2019