1994
Allocation de recherche du ministère de l'enseignement supérieur

Immunotherapy with B28, an antibody to Aβ oligomers, potently decreases amyloid plaques, microgliosis, and memory decline in APP knock-in mice.
Ting Yang; Yi Ran Xu; Shaomin Li; Jean-Pierre Bellier; Youqi Tao; Anna E Francis; Andrew M Stern; Shanxue Jin; Beth L Ostaszewski; Trebor L Lawton; Laurent Pradier; David Reczek; Cynthia A Lemere; Dominic M Walsh; Dennis J Selkoe
Cell reports, 30 Jun. 2026

Nuclear Speckle Protein SRRM2 Co-localized with Pathological Tau (pTauS396) in Neuronal and Glial Cells in Progressive Supranuclear Palsy.
Faris Hazwan Nazar; Aslina Pahrudin Arrozi; Tomoko Kato; Daijiro Yanagisawa; Yasushi Itoh; Ikuo Tooyama; Jean-Pierre Bellier
Acta histochemica et cytochemica, 27 Jun. 2026

Plasma phosphorylated tau 217 and longitudinal trajectories of Aβ, tau, and cognition in cognitively unimpaired older adults.
Hyun-Sik Yang; Juliana A U Anzai; Wai-Ying Wendy Yau; Brian C Healy; Andrea M Román Viera; Courtney Maa; Dylan Kirn; Michael J Properzi; Jean-Pierre Bellier; Aaron P Schultz; Michelle E Farrell; Heidi I L Jacobs; Rachel F Buckley; Kathryn V Papp; Gad A Marshall; Rebecca E Amariglio; Dorene M Rentz; Lei Liu; Dennis J Selkoe; Philip B Verghese; Joel B Braunstein; Keith A Johnson; Reisa A Sperling; Jasmeer P Chhatwal
Nature communications, 14 Apr. 2026

Identifying early changes in imaging, plasma, and digital cognitive biomarkers that correspond to Alzheimer's disease pathology in the presence of autopsy‐confirmed co‐pathologies
Charles D. Chen; Cinthya Aguero; Alexandra Melloni; Brian C. Healy; Emma G. Thibault; Jessie Fanglu Fu; Michelle E. Farrell; Stephanie Schultz; Hyun‐Sik Yang; Jean‐Pierre Bellier; Jasmeer Chhatwal; Pia Kivisäkk Webb; Steven Arnold; Dana Penney; Randall Davis; Dorene Rentz; Teresa Gomez‐Isla; Reisa A. Sperling; Keith A. Johnson; Julie C. Price
Alzheimer's & Dementia, 08 Jan. 2026, Refereed

An improved immunoassay detects Aβ oligomers in human biofluids: their CSF levels rise with tau and phosphotau levels.
Ting Yang; Yi Ran Xu; Shanxue Jin; Nagendran Ramalingam; Jean-Pierre Bellier; Alexandra M Lish; Beth L Ostaszewski; Tracy Young-Pearse; Lei Liu; Hyun-Sik Yang; Jasmeer P Chhatwal; Trebor L Lawton; Dennis J Selkoe
Alzheimer's research & therapy, 12 Jul. 2025

Inhibition of hippocampal mossy fiber plasticity and episodic memory by human Aβ oligomers is prevented by enhancing cAMP signaling in Alzheimer's mice.
Shan-Xue Jin; Jean-Pierre Bellier; Adrienne Wells; Paula Montero LIopis; Praju Vikas Anekal; Jason S Tresback; Barbara J Caldarone; Lei Liu; Shaomin Li; Ulf Dettmer; Nagendran Ramalingam; Dennis J Selkoe
Alzheimer's & dementia : the journal of the Alzheimer's Association, Apr. 2025

Neuronal Populations Involved in Motor Function Show Prominent Expression of Sbno1 During Postnatal Brain Development
Sunjidmaa Zolzaya; Dai Ihara; Munkhsoyol Erkhembaatar; Shinsuke Ochiai; Ayaka Isa; Mariko Nishibe; Jean-Pierre Bellier; Takahiro Shimizu; Satoshi Kikkawa; Ryo Nitta; Yu Katsuyama
Journal of Developmental Biology, 21 Jan. 2025, URL

Identification of fibrinogen as a plasma protein binding partner for lecanemab biosimilar IgG
Jean‐Pierre Bellier; Andrea M. Román Viera; Caitlyn Christiano; Juliana A. U. Anzai; Stephanie Moreno; Emily C. Campbell; Lucas Godwin; Amy Li; Alan Y. Chen; Sarah M. Alam; Adriana Saba; Han Bin Yoo; Hyun‐Sik Yang; Jasmeer P. Chhatwal; Dennis J. Selkoe; Lei Liu
Annals of Clinical and Translational Neurology, 30 Oct. 2024, Refereed

γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS).
Stephanie A Schultz; Lei Liu; Aaron P Schultz; Colleen D Fitzpatrick; Raina Levin; Jean-Pierre Bellier; Zahra Shirzadi; Nelly Joseph-Mathurin; Charles D Chen; Tammie L S Benzinger; Gregory S Day; Martin R Farlow; Brian A Gordon; Jason J Hassenstab; Clifford R Jack Jr; Mathias Jucker; Celeste M Karch; Jae-Hong Lee; Johannes Levin; Richard J Perrin; Peter R Schofield; Chengjie Xiong; Keith A Johnson; Eric McDade; Randall J Bateman; Reisa A Sperling; Dennis J Selkoe; Jasmeer P Chhatwal
The Lancet. Neurology, Sep. 2024

Uncovering elevated tau TPP motif phosphorylation in the brain of Alzheimer's disease patients
Jean‐Pierre Bellier; Yuqi Cai; Sarah M. Alam; Thorsten Wiederhold; Arica Aiello; Jonathan S. Vogelgsang; Sabina Berretta; Jasmeer P. Chhatwal; Dennis J. Selkoe; Lei Liu
Alzheimer's & Dementia, Mar. 2024

Knockout of the orphan membrane transporter Slc22a23 leads to a lean and hyperactive phenotype with a small hippocampal volume.
Yasuhiro Uchimura; Kodai Hino; Kosuke Hattori; Yoshinori Kubo; Airi Owada; Tomoko Kimura; Lucia Sugawara; Shinji Kume; Jean-Pierre Bellier; Daijiro Yanagisawa; Akihiko Shiino; Takahisa Nakayama; Yataro Daigo; Tomoji Mashimo; Jun Udagawa
PloS one, 2024

Curcumin tautomerization in the mechanism of pentameric amyloid- β42 oligomers disassembly
Atsuya Matsui; Jean-Pierre Bellier; Daiki Hayashi; Takafumi Ishibe; Yoshiaki Nakamura; Hiroyasu Taguchi; Nobuyasu Naruse; Yutaka Mera
Biochemical and Biophysical Research Communications, Jul. 2023, Refereed

Optimization of 3D Immunofluorescence Analysis and Visualization Using IMARIS and MeshLab
Zulzikry Hafiz Abu Bakar; Jean-Pierre Bellier; Wan Zurinah Wan Ngah; Daijiro Yanagisawa; Ken-ichi Mukaisho; Ikuo Tooyama
Cells, 04 Jan. 2023, Refereed

Regional differences of extrinsic and intrinsic cholinergic innervation and alterations by chronic opioid-induced constipation in the porcine colonic enteric nerve system
Jean-Pierre Bellier
PHYSIOLOGY, 2023

Functional variations in gamma-secretase activity are critical determinants of the clinical, biomarker, and cognitive progression of autosomal dominant Alzheimer's disease
Jean-Pierre Bellier
bioRxiv, 2023

New insight on the enteric cholinergic innervation of the pig colon by central and peripheral nervous systems: reduction by repeated loperamide administration.
Pu-Qing Yuan; Tao Li; Mulugeta Million; Muriel Larauche; Karim Atmani; Jean-Pierre Bellier; Yvette Taché
Frontiers in neuroscience, 2023

Structure optimization of the toxic conformation model of amyloid β42 by intramolecular disulfide bond formation
Yuka Matsushima; Yumi Irie; Yusuke Kageyama; Jean-Pierre Bellier; Ikuo Tooyama; Takahito Maki; Toshiaki Kume; Ryo C Yanagita; Kazuhiro Irie
ChemBioChem, 15 Feb. 2022, Refereed

The Effect of Ethanol on Disassembly of Amyloid-β1-42 Pentamer Revealed by Atomic Force Microscopy and Gel Electrophoresis
Atsuya Matsui; Jean-Pierre Bellier; Takeshi Kanai; Hiroki Satooka; Akio Nakanishi; Tsukasa Terada; Takafumi Ishibe; Yoshiaki Nakamura; Hiroyasu Taguchi; Nobuyasu Naruse; Yutaka Mera
International Journal of Molecular Sciences, 14 Jan. 2022, Refereed, Corresponding

LC3/FtMt Colocalization Patterns Reveal the Progression of FtMt Accumulation in Nigral Neurons of Patients with Progressive Supranuclear Palsy
Zulzikry Hafiz Abu Bakar; Jean Pierre Bellier; Daijiro Yanagisawa; Tomoko Kato; Ken Ichi Mukaisho; Ikuo Tooyama
International Journal of Molecular Sciences, 01 Jan. 2022, Refereed, Corresponding

Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain
Yusuke Kageyama; Yumi Irie; Yuka Matsushima; Tatsuya Segawa; Jean-Pierre Bellier; Kumi Hidaka; Hiroshi Sugiyama; Daita Kaneda; Yoshio Hashizume; Hiroyasu Akatsu; Kunio Miki; Akiko Kita; Douglas G. Walker; Kazuhiro Irie; Ikuo Tooyama
ACS Chemical Neuroscience, 31 Aug. 2021, Refereed

Immunohistochemical Study of Mitochondrial Ferritin in the Midbrain of Patients with Progressive Supranuclear Palsy.
Zulzikry Hafiz Abu Bakar; Tomoko Kato; Daijiro Yanagisawa; Jean-Pierre Bellier; Ken-Ichi Mukaisho; Ikuo Tooyama
Acta histochemica et cytochemica, 29 Jun. 2021, Refereed

Editorial: Brain Evolution: Clues From Aquatic Organisms
Paolo de Girolamo; Jean-Pierre Bellier; Livia D'Angelo
Frontiers in Neuroanatomy, 07 May 2021, Not refereed, Invited

Intrinsic cholinergic innervation in the human sigmoid colon revealed using CLARITY, three‐dimensional (3D) imaging, and a novel anti‐human peripheral choline acetyltransferase (hpChAT) antiserum
Pu‐Qing Yuan; Jean‐Pierre Bellier; Tao Li; Mary R. Kwaan; Hiroshi Kimura; Yvette Taché
Neurogastroenterology & Motility, Apr. 2021, Refereed

3D imaging and computational quantitation of extrinsic and intrinsic cholinergic innervation in the enteric nervous system (ENS) of the pig colon: implications in the cholinergic anti-inflammatory pathway (CAP)
Jean-Pierre Bellier
NEUROGASTROENTEROLOGY AND MOTILITY, 2021

Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology.
Anarmaa Mendsaikhan; Ikuo Tooyama; Jean-Pierre Bellier; Geidy E Serrano; Lucia I Sue; Lih-Fen Lue; Thomas G Beach; Douglas G Walker
Acta neuropathologica communications, 21 Dec. 2019, Refereed, Not invited

The juvenility-associated long noncoding RNA Gm14230 maintains cellular juvenescence.
Ayami Tano; Yosuke Kadota; Takao Morimune; Faidruz Azura Jam; Haruka Yukiue; Jean-Pierre Bellier; Tatsuyuki Sokoda; Yoshihiro Maruo; Ikuo Tooyama; Masaki Mori
Journal of cell science, 16 Apr. 2019, Refereed, Not invited

A Novel Antiserum Against a Predicted Human Peripheral Choline Acetyltransferase (hpChAT) for Labeling Neuronal Structures in Human Colon.
Jean-Pierre Bellier; Pu-Qing Yuan; Kenichi Mukaisho; Ikuo Tooyama; Yvette Taché; Hiroshi Kimura
Frontiers in neuroanatomy, 2019, Refereed, Not invited

Proteome profiling in the hippocampus, medial prefrontal cortex, and striatum of aging rat
Hamizah Shahirah Hamezah; Lina Wati Durani; Daijiro Yanagisawa; Nor Faeizah Ibrahim; Jean Pierre Bellier; Suzana Makpol; Wan Zurinah; Wan Ngah; Hanafi Ahmad Damanhuri; Ikuo Tooyama
Experimental Gerontology, Oct. 2018, Refereed, Not invited

Immunohistochemical and biochemical evidence for the presence of serotonin-containing neurons and nerve fibers in the octopus arm
Jean-Pierre Bellier; Yu Xie; Sameh Mohamed Farouk; Yuko Sakaue; Ikuo Tooyama; Hiroshi Kimura
BRAIN STRUCTURE & FUNCTION, Sep. 2017, Refereed, Not invited

Mitochondrial ferritin protects SH-SY5Y cells against H2O2-induced oxidative stress and modulates alpha-synuclein expression
Hongpeng Guan; Hongkuan Yang; Mingchun Yang; Daijiro Yanagisawa; Jean-Pierre Bellier; Masaki Mori; Shogo Takahata; Takashi Nonaka; Shiguang Zhao; Ikuo Tooyama
EXPERIMENTAL NEUROLOGY, May 2017, Refereed, Not invited

Localization of Brain Natriuretic Peptide Immunoreactivity in Rat Spinal Cord
Essam M. Abdelalim; Jean-Pierre Bellier; Ikuo Tooyama
FRONTIERS IN NEUROANATOMY, Dec. 2016, Refereed, Not invited

Mitochondrial ferritin affects mitochondria by stabilizing HIF-1 alpha in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration
Xiying Wang; Hongkuan Yang; Daijiro Yanagisawa; Jean-Pierre Bellier; Katsutaro Morino; Shiguang Zhao; Ping Liu; Piers Vigers; Ikuo Tooyama
NEUROBIOLOGY OF AGING, Nov. 2016, Refereed, Not invited

ミトコンドリアフェリチンは細胞を保護してα-Synuclein発現を調節する(Mitochondrial Ferritin Protects Cells and Modulates α-Synuclein Expression)
関 宏鵬; 楊 宏寛; 楊 明春; 柳沢 大治郎; Bellier Jean-Pierre; 野中 隆; 趙 世光; 遠山 育夫
Dementia Japan, Oct. 2016

MAPPING OF MITOCHONDRIAL FERRITIN IN THE BRAINSTEM OF MACACA FASCICULARIS
Mingchun Yang; Hongkuan Yang; Hongpeng Guan; Jean-Pierre Bellier; Shiguang Zhao; Ikuo Tooyama
NEUROSCIENCE, Jul. 2016, Refereed, Not invited

Immunohistochemical localization of two types of choline acetyltransferase in neurons and sensory cells of the octopus arm
Yuko Sakaue; Jean-Pierre Bellier; Shin Kimura; Loredana D'Este; Yoshihiro Takeuchi; Hiroshi Kimura
BRAIN STRUCTURE & FUNCTION, Jan. 2014, Refereed, Not invited

Expression of NPR-B in neurons of the dorsal root ganglia of the rat
Essam M. Abdelalim; Jean-Pierre Bellier; Ikuo Tooyama
Peptides, May 2013, Not refereed, Not invited

Peripheral choline acetyltransferase in rat skin demonstrated by immunohistochemistry
Keiji Hanada; Saburo Kishimoto; Jean-Pierre Bellier; Hiroshi Kimura
Cell and Tissue Research, 2013, Not refereed, Not invited

Expression of NPR-B in neurons of the dorsal root ganglia of the rat. Peptides.
Peptides, 2013, Not refereed, Not invited

Immunoreactivity for choline acetyltransferase of peripheral-type (pChAT) in the trigeminal ganglion neurons of the non-human primate Macaca fascicularis.
KOGA Tsuneyuki; KOGA Tsuneyuki; BELLIER Jean-pierre; KIMURA Hiroshi; TOOYAMA Ikuo
Acta Histochem Cytoc, 2013, Not refereed, Not invited

Peripheral choline acetyltransferase in rat skin demonstrated by immunohistochemistry
Keiji Hanada; Saburo Kishimoto; Jean-Pierre Bellier; Hiroshi Kimura
Cell Tissue Res, 2013, Not refereed, Not invited

Immunoreactivity for choline acetyltransferase of peripheral-type (pChAT) in the trigeminal ganglion neurons of the non-human primate Macaca fascicularis
Tsuneyuki Koga; Jean-Pierre Bellier; Hiroshi Kimura; Ikuo Tooyama
Acta Histochemica et Cytochemica, 2013, Not refereed, Not invited

Chemical neuroanatomy of the cholinergic neurons in the cephalopod octopus and the gastropod Limax
Jean-Pierre Bellier; Arianna Casini; Yuko Sakaue; Shin Kimura; Hiroshi Kimura; Tindaro G. Renda; Loredana D'Este
Mollusks: Morphology, Behavior and Ecology, Jan. 2012

Immunolocalization of choline acetyltransferase of common type in the central brain mass of Octopus vulgaris
A. Casini; R. Vaccaro; L. D'Este; Y. Sakaue; J. P. Bellier; H. Kimura; T. G. Renda
EUROPEAN JOURNAL OF HISTOCHEMISTRY, 2012, Not refereed, Not invited

Peripheral type of choline acetyltransferase: Biological and evolutionary implications for novel mechanisms in cholinergic system
J. -P. Bellier; H. Kimura
JOURNAL OF CHEMICAL NEUROANATOMY, Dec. 2011, Not refereed, Not invited

Immunohistochemical demonstration of cholinergic structures in central ganglia of the slug (Limax maximus, Limax valentianus)
Loredana D'Este; Arianna Casini; Shin Kimura; Jean-Pierre Bellier; Etsuro Ito; Hiroshi Kimura; Tindaro G. Renda
NEUROCHEMISTRY INTERNATIONAL, Apr. 2011, Not refereed, Not invited

Choline acetyltransferase of the common type immunoreactivity in the rat brain following different heroin treatments: A pilot study
Arianna Casini; Giorgio Vivacqua; Francesco E. Pontieri; Hiroshi Kimura; Jean P. Bellier; Loredana D'Este; Tindaro G. Renda
JOURNAL OF CHEMICAL NEUROANATOMY, Mar. 2011, Not refereed, Not invited

Nuclear Choline Acetyltransferase Activates Transcription of a High-affinity Choline Transporter
Akinori Matsuo; Jean-Pierre Bellier; Masaki Nishimura; Osamu Yasuhara; Naoaki Saito; Hiroshi Kimura
JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2011, Not refereed, Not invited

Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter
MATSUO Akinori; BELLIER Jean-Pierre; NISHIMURA Masaki; YASUHARA Osamu; SAITO Naoaki; KIMURA Hiroshi
Journal of Biological Chemistry, 2011, Not refereed, Not invited

Immunohistochemical demonstration of cholinergic structures in central ganglia of the slug (Limax maximus, Limax valentianus).
Neurochem Int, 2011, Not refereed, Not invited

Choline acetyltransferase of the common type immunoreactivity in the rat brain following different heroin treatments: a pilot study.
J Chem Neuroanat, 2011, Not refereed, Not invited

Axotomy Alters Alternative Splicing of Choline Acetyltransferase in the Rat Dorsal Motor Nucleus of the Vagus Nerve
Atsushi Saito; Takashi Sato; Hiroyuki Okano; Ken-Ichiro Toyoda; Hitoshi Bamba; Shin Kimura; Jean-Pierre Bellier; Akinori Matsuo; Hiroshi Kimura; Yasuo Hisa; Ikuo Tooyama
JOURNAL OF COMPARATIVE NEUROLOGY, Mar. 2009, Not refereed, Not invited

First visualization of cholinergic cells and fibers by immunohistochemistry for choline acetyltransferase of the common type in the optic lobe and peduncle complex of Octopus vulgaris
Loredana D'Este; Shin Kimura; Arianna Casini; Akinori Matsuo; Jean-Pierre Bellier; Hiroshi Kimura; Tindaro G. Renda
JOURNAL OF COMPARATIVE NEUROLOGY, Aug. 2008, Not refereed, Not invited

Distribution of natriuretic peptide receptor-C immunoreactivity in the rat brainstem and its relationship to cholinergic and catecholaminergic neurons
E. M. Abdelalim; C. Masuda; J. P. Bellier; A. Saito; S. Yamamoto; N. Mori; I. Tooyama
NEUROSCIENCE, Jul. 2008, Not refereed, Not invited

First visualization of cholinergic cells and fibers by immunohistochemistry for choline acetyltransferase of the common type in the optic lobe and peduncle complex of Octopus vulgaris.
J Comp Neurol, 2008, Not refereed, Not invited

Acetylcholine synthesis by choline acetyltransferase of a peripheral type as demonstrated in adult rat dorsal root ganglion
Jean-Pierre Bellier; Hiroshi Kimura
Journal of Neurochemistry, Jun. 2007, Not refereed, Not invited

Demonstration of choline acetyltransferase of a peripheral type in the rat heart
Osamu Yasuhara; Akinori Matsuo; Jean-Pierre Bellier; Yoshinari Aimi
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, Mar. 2007, Not refereed, Not invited

The production of antibodies that distinguish rat choline acetyltransferase from its splice variant product of a peripheral type
Shin Kimura; Jean-Pierre Bellier; Akinori Matsuo; Ikuo Tooyama; Hiroshi Kimura
NEUROCHEMISTRY INTERNATIONAL, Jan. 2007, Not refereed, Not invited

Acetylcholine synthesis by choline acetyltransferase of a peripheral type as demonstrated in adult rat dorsal root ganglion
Jean-Pierre Bellier
JOURNAL OF NEUROCHEMISTRY, 2007, Not refereed, Not invited

The production of antibodies that distinguish rat choline acetyltransferase from its splice variant product of a peripheral type.
Neurochem Int, 2007, Not refereed, Not invited

Demonstration of choline acetyltransferase of a peripheral type in the rat heart.
J Histochem Cytochem., 2007, Not refereed, Not invited

Central vagal stimulation activates enteric cholinergic neurons in the stomach and VIP neurons in the duodenum in conscious rats
PQ Yuan; H Kimura; M Million; JP Bellier; LX Wang; GV Ohning; Y Tache
PEPTIDES, Apr. 2005, Not refereed, Not invited

Rat choline acetyltransferase of the peripheral type differs from that of the common type in intracellular translocation
A Matsuo; JP Bellier; T Hisano; Y Aimi; O Yasuhara; Tooyama, I; N Saito; H Kimura
NEUROCHEMISTRY INTERNATIONAL, Apr. 2005, Not refereed, Not invited

Central vagal stimulation activates enteric cholinergic neurons in the stomach and VIP neurons in the duodenum in conscious rats.
Peptides, 2005, Not refereed, Not invited

Rat choline acetyltransferase of the peripheral type differs from that of the common type in translocation.
Neurochem. Int., 2005, Not refereed, Not invited

ラット眼組織のコリン神経支配 新規アセチルコリン合成酵素pChATによる再評価(Re-evaluation of cholinergic innervation of rat ocular tissues using choline acetyltransferase of a peripheral type as a marker)
安原 治; 相見 良成; 松尾 明典; Bellier Jean-Pierre; Elnasharty Mohamed; 遠山 育夫; 木村 宏
神経化学, Aug. 2004

Innervation of rat iris by trigentinal and ciliary neurons expressing pChAT, a novel splice variant of choline acetyltransferase
O Yasuhara; Y Aimi; A Shibano; A Matsuo; JP Bellier; M Park; Tooyama, I; H Kimura
JOURNAL OF COMPARATIVE NEUROLOGY, Apr. 2004, Not refereed, Not invited

Innervation of rat iris by trigeminal and ciliary neurons expressing pChAT, a novel splice variant of choline acetyltranferase
Osamu Yasuhara; Yoshinari Aimi; Akira Shibano; Akinori Matsuo; Jean‐Pierre Bellier; Masami Park; Ikuo Tooyama; Hiroshi Kimura
J Comp Neurol, 2004, Not refereed, Not invited

Demonstration of cholinergic ganglion cells in rat retina: Expression of an alternative splice variant of choline acetyltransferase
O Yasuhara; Tooyama, I; Y Aimi; JP Bellier; T Hisano; A Matsuo; M Park; H Kimura
JOURNAL OF NEUROSCIENCE, Apr. 2003, Not refereed, Not invited

Expression of a splice variant of choline acetyltransferase in magnocellular neurons of the tuberomammillary nucleus of rat
H Kanayama; O Yasuhara; A Matsuo; Tooyama, I; Y Aimi; JP Bellier; JI Nagy; K Fukui; H Kimura
NEUROSCIENCE, 2003, Not refereed, Not invited

Demonstration of cholinergic ganglion cells in rat retina: expression of an alternative splice variant of choline acetyltransferase.
Osamu Yasuhara; Ikuo Tooyama; Yoshinari Aimi; Jean-Pierre Bellier; Tadashi Hisano; Akinori Matsuo; Masami Park; Hiroshi Kimura
J Neurosci, 2003, Not refereed, Not invited

Expression of a splice variant of choline acetyltransferase in magnocellular neurons of the tuberomammillary nucleus of rat.
Neuroscience, 2003, Not refereed, Not invited

Morphologic study of neuronal death, glial activation, and progenitor cell division in the hippocampus of rat models of epilepsy
Tooyama, I; JP Bellier; M Park; P Minnasch; S Uemura; T Hisano; M Iwami; Y Aimi; O Yasuhara; H Kimura
EPILEPSIA, 2002, Not refereed, Not invited

Molecular Mechanisms in Alzheimer’s Disease
Res Legal Medicine, 2002, Not refereed, Not invited

Morphologic study of neuronal death, glial activation, and progenitor cell division in the hippocampus of rat models of epilepsy.
Ikuo Tooyama; Jean-Pierre Bellier; Masami Park; Petra Minnasch; Shuji Uemura; Tadashi Hisano; Mika Iwami; Yoshinari Aimi; Osamu Yasuhara; Hiroshi Kimura
Epilepsia, 2002, Not refereed, Not invited

Molecular Mechanisms in Alzheimer’s Disease
Res Legal Medicine, 2002, Not refereed, Not invited

Enhanced neuronal protection from oxidative stress by coculture with glutamic acid decarboxylase-expressing astrocytes
C Lamigeon; JP Bellier; S Sacchettoni; M Rujano; B Jacquemont
JOURNAL OF NEUROCHEMISTRY, Apr. 2001, Not refereed, Not invited

培養後根神経節におけるアセチルコリン合成能の証明(Demonstration of cholinergic properties in cultured rat dorsal root ganglion neurons)
相見 良成; 二宮 孝文; 遠山 育夫; 安原 治; Bellier Jean-Pierre; 木村 宏
解剖学雑誌, Feb. 2001

Enhanced neuronal protection from oxidative stress by coculture with glutamic acid decarboxylase-expressing astrocytes
J Neurochem, 2001, Not refereed, Not invited

Glutamic acid decarboxylase-expressing astrocytes exhibit enhanced energetic metabolism and increase PC12 cell survival under glucose deprivation
JP Bellier; S Sacchettoni; C Prod'hon; A Perret-Liaudet; MF Belin; B Jacquemont
JOURNAL OF NEUROCHEMISTRY, Jul. 2000, Not refereed, Not invited

Glutamic acid decarboxylase-expressing astrocytes exhibit enhanced energetic metabolism and increase PC12 cell survival under glucose deprivation
Bellier, J.P.; Sacchettoni, S.; Prod{'}hon, C.; Perret-Liaudet, A.; Belin, M.F.; Jacquemont, B.
Journal of Neurochemistry, 2000, Not refereed, Not invited, URL

Transforming growth factor alpha expression as a response of murine motor neurons to axonal injury and mutation-induced degeneration
F Lisovoski; S Blot; C Lacombe; JP Bellier; PA Dreyfus; MP Junier
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, May 1997, Refereed, Not invited

Neuregulins: A new family of growth factors
MP Junier; JP Bellier
M S-MEDECINE SCIENCES, Apr. 1996, Refereed, Not invited

Les neuregulines: une nouvelle famille de facteurs de croissance.
MS-Med. Sci., 1994, Refereed, Invited

CNS-Tau Specific Antibodies Illuminate Disease Signatures Across Tauopathies.
Lei Liu; Yin Zheng; Luke Slominski; Qimin Quan; Adriana Saba; Jean-Pierre Bellier; Han-Bin Yoo; Andrea Roman; Elizabeth L Hennessey; Samadhi P Wijethunga; Elif L Okyay; Michael B Miller; Hyun-Sik Yang; Dennis J Selkoe; Jasmeer P Chhatwal
bioRxiv : the preprint server for biology, 17 Sep. 2025

SRRM2 is localized to tau aggregates in the brain of PSP
NAZAR Faris Hazwan; KATO Tomoko; ARROZI Aslina Pahrudin; YANAGISAWA Daijiro; BELLIER Jean-Pierre; ITOH Yasushi; TOOYAMA Ikuo
Dementia Japan, 2025

The role of curcumin tautomerization in the disassembly of pentameric amyloid β42 oligomers
Matsui Atsuya; Bellier Jean Pierre; Fujii Koutaro; Ishibe Takafumi; Nakamura Yoshiaki; Taguchi Hiroyasu; Naruse Nobuyasu; Mera Yutaka
Abstract book of Annual Meeting of the Japan Society of Vacuum and Surface Science, 2023

PSP患者の中脳におけるFtMt 免疫組織化学的研究(FtMt in the Midbrain of Patients with PSP: An Immunohistochemical Study)
Hafiz Abu Bakar Zulzikry; Kato Tomoko; Yanagisawa Daijiro; Bellier Jean-Pierre; Mukaisho Kenichi; Tooyama Ikuo
老年精神医学雑誌, Nov. 2022

FtMt in the Midbrain of Patients with PSP: An Immunohistochemical Study
HAFIZ Abu Bakar Zulzikry; KATO Tomoko; YANAGISAWA Daijiro; BELLIER Jean-Pierre; MUKAISHO Kenichi; TOOYAMA Ikuo
Dementia Japan, 2022

進行性核上性麻痺の患者の中脳におけるミトコンドリアフェリチンの免疫組織化学的研究(Immunohistochemical Study of Mitochondrial Ferritin in the Midbrain of Patients with Progressive Supranuclear Palsy)
Bakar Zulzikry Hafiz Abu; Kato Tomoko; Yanagisawa Daijiro; Bellier Jean-Pierre; Mukaisho Ken-ichi; Tooyama Ikuo
Acta Histochemica et Cytochemica, Jun. 2021
https://search.jamas.or.jp/default/link?pub_year=2021&ichushi_jid=J04470&link_issn=&doc_id=20210709360003&doc_link_id=10.1267%2Fahc.21-00019&url=https%3A%2F%2Fdoi.org%2F10.1267%2Fahc.21-00019&type=Crossref&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00002_2.gif

Reappraisal of acetylcholinesterase staining: a nanomaterial hidden into an old technique
BELLIER Jean-Pierre; TOOYAMA Ikuo
日本組織細胞化学会総会・学術集会講演プログラム・予稿集, 2021

Characterization of Mitochondrial Ferritin Localization in the Midbrain of Patients with Progressive Supranuclear Palsy
BAKAR Zulzikry Hafiz Abu; KATO Tomoko; YANAGISAWA Daijiro; BELLIER Jean-Pierre; MUKAISHO Kenichi; TOOYAMA Ikuo
日本組織細胞化学会総会・学術集会講演プログラム・予稿集, 2021

運動が脳の若さを維持し認知症を予防する分子生理機序の解明
森雅樹; 遠山育夫; 水野大介; 乾雅史; 千葉朋希; BELLIER Jean-Pierre; JAM Faidruz Azura; 田埜郁実
若手研究者のための健康科学研究助成成果報告書, 2019

Visualization of peripheral choline acetyltransferase in human tissue: From predicted peptide sequence to antiserum production
BELLIER Jean-Pierre; YUAN Pu-Qing; MUKAISHO Kenichi; TOOYAMA Ikuo; TACHE Yvette; KIMURA Hiroshi
日本組織細胞化学会総会・学術集会講演プログラム・予稿集, 2019

Developing a novel antiserum against human peripheral choline acetyltransferase
BELLIER Jean-Pierre; TOOYAMA Ikuo; KIMURA Hiroshi
日本脳科学会プログラム・講演抄録集, 2019

Comparative anatomy of the serotoninergic pathways in the peripheral nervous system of vertebrate and cephalopods
BELLIER Jean-Pierre; XIE Yu; BELLANGER Cecile; TOOYAMA Ikuo
日本組織細胞化学会総会・学術集会講演プログラム・予稿集, 2018

タコの足の神経解剖についての5-hydroxytryptamineとcholine acetyltransferase isoformに対する免疫組織化学染色による解明(The octopus arm neuroanatomy revealed by immunohistochemistry for 5-hydroxytryptamine and choline acetyltransferase isoforms)
Bellier Jean-Pierre; Yu Xie; Sakaue Yuko; Tooyama Ikuo
生命科学系学会合同年次大会, Dec. 2017

金属イオンとイメージングの最前線 全組織透明化法を用いたカルシウム結合タンパク質の可視化(Visualization of calcium-binding proteins by whole tissue clarification methods)
Bellier Jean-Pierre; Tooyama Ikuo
日本組織細胞化学会総会・学術集会講演プログラム・予稿集, Sep. 2017

In vivo evaluation of interaction between GTP cyclohydrolase 1 and its regulatory protein GFRP in the rat brain stem
J-P. Bellier; Y. Xie; I. Tooyama; H. Kimura
JOURNAL OF NEUROCHEMISTRY, Aug. 2017, Not refereed, Not invited

The octopus arm neuroanatomy revealed by immunohistochemistry for 5-hydroxytryptamine and choline acetyltransferase isoforms
BELLIER Jean-Pierre; YU Xie; SAKAUE Yuko; TOOYAMA Ikuo
日本生化学会大会(Web), 2017

Visualization of calcium-binding proteins by whole tissue clarification methods
BELLIER Jean-Pierre; TOOYAMA Ikuo
日本組織細胞化学会総会・学術集会講演プログラム・予稿集, 2017

The peripheral type of choline acetyltransferase, a marker for peripheral cholinergic neurons in invertebrate and vertebrate
BELLIER Jean-Pierre; TOOYAMA Ikuo
日本解剖学会総会・全国学術集会講演プログラム・抄録集, 2017

ヒト心筋Kv1.5チャネルに及ぼすプロテインキナーゼCの調節作用(Protein kinase C regulates human cardiac Kv1.5 potassium channels)
Ding Wei-Guang; Bai Jiayu; Toyoda Futoshi; Bellier Jean-Pierre; Matsuura Hiroshi
The Journal of Physiological Sciences, Mar. 2016

Antiserum as a pan-neuronal immuno-marker for enteric neurons in rodents
BELLIER Jean-Pierre; XIE Yu; TACHE Yvette; TOOYAMA Ikuo; KIMURA Hiroshi
日本組織細胞化学会総会・学術集会講演プログラム・予稿集, 2016

P3-09 Production of antibody to Mitochondrial Ferritin and its application to immunohistochemical study in monkey brainstem :
Yang Mingchun; Yang Hongkuan; Guan Hongpeng; Bellier Jean-Pierre; Zhao Shiguang; Tooyama Ikuo
日本組織細胞化学会総会・学術集会講演プログラム・予稿集, 2015

蛍光組織化学法と透明化技術で脳の中を観察する(IV.組織化学の未来(2),じっくり学ぶ組織細胞化学の基礎と応用そして未来)
Bellier Jean-Pierre; 遠山 育夫
組織細胞化学, 10 Jul. 2014

モルモットにおける洞房結節細胞のIKs電流に対するβ2アドレナリン受容体の機能的調節(Functional regulation of β2-adrenoceptors on IKs current of sinoatrial node cells in guinea pig)
Ding Wei-Guang; Bai Jiayu; Xie Yu; Toyoda Futoshi; Bellier Jean-Pierre; Matsuura Hiroshi
The Journal of Physiological Sciences, Mar. 2014

ラット脳幹におけるGTPシクロヒドロラーゼ1とその調節蛋白質(GFRP)(GTP cyclohydrolase 1 and its regulatory protein(GFRP) in the rat brain stem)
Bellier Jean-Pierre; Ding Wei-Guang; Sakaue Yuko; Yasuhara Osamu; Matsuura Hiroshi; Tooyama Ikuo
The Journal of Physiological Sciences, Mar. 2014

胎生初期低栄養ラットに認められる行動異常は,脳内セロトニン神経活性と関連しうる
原澤俊也; 金子隼也; 河野匡暁; 野津瑛未奈; 金井裕彦; 小島秀人; 山田尚登; BELLIER Jean-Pierre; 松田和郎; 松田和郎; 岡野純子; 宇田川潤
日本解剖学会総会・全国学術集会講演プログラム・抄録集, 2013

P-36 非ヒト霊長類カニクイザル三叉神経節ニューロンにおける末梢型コリンアセチルトランスフェラーゼ(pChAT)の免疫組織化学的解析(神経系・神経科学関連領域,ポスター,第54回日本組織細胞化学会総会・学術集会)
古賀 恒行; 木村 宏; Bellier Jean-Pierre; 遠山 育夫
日本組織細胞化学会総会プログラムおよび抄録集, 2013

Peripheral type of choline acetyltransferase (pChAT) immunoreactivity in the trigeminal ganglion neuron of the non-human primate macaca fascicularis
T. Koga; J. -P. Bellier; I. Tooyama
JOURNAL OF NEUROCHEMISTRY, Oct. 2012, Not refereed, Not invited

Distribution of the GTP cyclohydrolase 1 feedback regulatory protein (GFRP) in the rat brain stem
J. -P. Bellier; W. -G. Ding; O. Yasuhara; A. Matsuo; I. Tooyama
JOURNAL OF NEUROCHEMISTRY, Oct. 2012, Not refereed, Not invited

コリンアセチルトランスフェラーゼの局在と機能
木村宏; BELLIER Jean-Pierre; 木村新
Clinical Neuroscience, 2012, Not refereed, Not invited

CHOLINERGIC SYSTEM OF Octopus vulgaris: NEW CUES FROM CCHAT AND PCHAT IMMUNOHISTOCHEMISTRY.
L. D'Este; A. Casini; R. Vaccaro; J. -P. Bellier; H. Kimura
JOURNAL OF SHELLFISH RESEARCH, Dec. 2011, Not refereed, Not invited

Deterioration of barrier function of nuclear pore complexes in aging neurons-Immunohistochemical evaluation using antibodies against scaffold nucleoporins
Akinori Matsuo; Jean-Pierre Bellier; Shinichiro Nakamura
NEUROSCIENCE RESEARCH, 2011, Not refereed, Not invited

Peripheral type choline acetyltransferase in the human intestine and dorsal root ganglion
BELLIER Jean-Pierre; KIMURA Shin; SAKAUE Yuko; KIMURA Hiroshi
神経化学, 2010

Peripheral type choline acetyltransferase in the human intestine and dorsal root ganglion
Jean-Pierre Bellier; Shin Kimura; Yuko Sakaue; Hiroshi Kimura
NEUROSCIENCE RESEARCH, 2010, Not refereed, Not invited

Nuclear choline acetyltransferase activates transcription of high-affinity choline transporter
Akinori Matsuo; Jean-Pierre Bellier; Masaki Nishimura; Osamu Yasuhara; Naoaki Saito; Hiroshi Kimura
NEUROSCIENCE RESEARCH, 2010, Not refereed, Not invited

Immunohistochemical localization of the peripheral type choline acetyltransferase in colon and dorsal root ganglion of human
BELLIER Jean-Pierre; KIMURA Shin; SAKAUE Yuko; KIMURA Hiroshi
日本組織細胞化学会総会・学術集会講演プログラム・予稿集, 2009

Choline acetyltransferase of a peripheral type (pChAT) synthesizes acetylcholine in adult rat dorsal root ganglion
BELLIER Jean-Pierre; KIMURA Hiroshi
神経化学, 2007

成熟ラット後根神経節における末梢型コリンアセチルトランスフェラーゼによるアセチルコリン合成(Acetylcholine synthesis by choline acetyltransferase of a peripheral type in adult rat dorsal root ganglion)
Bellier Jean-Pierre; Aimi Yoshinari; Matsuo Akinori; Yasuhara Osamu; Kimura Shin; Tooyama Ikuo; Kimura Hiroshi
Acta Histochemica et Cytochemica, Dec. 2005
https://search.jamas.or.jp/default/link?pub_year=2005&ichushi_jid=J04470&link_issn=&doc_id=20060210300033&doc_link_id=10804964&url=http%3A%2F%2Fdl.ndl.go.jp%2Finfo%3Andljp%2Fpid%2F10804964&type=%E5%9B%BD%E7%AB%8B%E5%9B%BD%E4%BC%9A%E5%9B%B3%E6%9B%B8%E9%A4%A8%E3%83%87%E3%82%B8%E3%82%BF%E3%83%AB%E3%82%B3%E3%83%AC%E3%82%AF%E3%82%B7%E3%83%A7%E3%83%B3&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00035_3.gif

ニホンザル線条体からのcholine acetyltransferase(ChAT)のクローニング(Cloning of monkey choline acetyltransferase (CHAT) from the striatum of Japanese macaque (Maccaca fuscata))
Song Yang; Kimura Shin; Jean-Pierre Bellier; Yasuhara Osamu; Kimura Hiroshi; Torii Rhyuzo; Tooyama Ikuo
Neuroscience Research, Jul. 2005

コリンアセチルトランフフェラーゼの新規スプライシング変異体pChATのブタ小腸からの精製(Purification of pChAT, a novel splice variant of choline acetyltransferase, from porcine small intestine)
Bellier Jean-Pierre; Aimi Yoshinari; Matsuo Akinori; Yasuhara Osamu; Tooyama Ikuo; Kimura Hiroshi
神経化学, Aug. 2003

ラット翼突口蓋神経節由来のコリンアセチルトランスフェラーゼmRNA(pChAT2)の新規スプライスバリアントのクローニング(Cloning of a novel splice variant of choline acetyltransferase mRNA (pChAT2) from rat pterygopalatine ganglion)
Hisano Tadashi; Tooyama Ikuo; Toyoda Ken-ichiro; Bellier Jean-Pierre; Aimi Yoshinari; Yasuhara Osamu; Kimura Hiroshi
Neuroscience Research, Jul. 2003

ラットの脊髄後根神経節における臓器の求心性ニューロンにおける末梢型(pChAT)のコリンアセチルトランスフェラーゼ(Choline acetyltransferase of a peripheral type (pChAT) in visceral afferent neurons in dorsal root ganglia of rat)
Aimi Yoshinari; Nakajima Kyoji; Bellier Jean-Pierre; Matsuo Akinori; Yasuhara Osamu; Tooyama Ikuo; Kimura Hiroshi
Neuroscience Research, Jul. 2003

神経伝達物質 コリンアセチルトランスフェラーゼの新しいスプライシング変異体pChATの生化学的性質と部分的精製(Biochemical properties and partial purification of pChAT, a novel splice variant of choline acetyltransferase)
Bellier Jean-Pierre; Aimi Yoshinari; Park Masami; Hisano Tadashi; Minnasch Petra; Matsuo Akinori; Yasuhara Osamu; Tooyama Ikuo; Kimura Hiroshi
神経化学, Jun. 2002

B-20 Putative Cholinergic Innervation of Rat Iris Revealed by Immunohistochemistry for Choline Acetyltransferase of a Peripheral Type :
YASUHARA Osamu; TOOYAMA Ikuo; AIMI Yoshinara; BELLIER Jean-Pierre; KIMURA Hiroshi
Acta histochemica et cytochemica, 2001

Chemical Neuroanatomy of the Cholinergic Neurons in the Cephalopod Octopus and the Gastropod Limax.
Nova Science Publishers, 2012, Not refereed

Jan. 2026, Present
THE JAPANESE SOCIETY FOR NEUROCHEMISTRY

Jan. 2015, Present
Society for Neuroscience

Evaluation of an immunotherapy for chronic pain by expressing a single domain intrabody against the pain marker GCH1 in the rat dorsal root ganglion neurons
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
01 Apr. 2018, 31 Mar. 2022

Therapeutic potential of the metabolic relationship between the product of two genetic markers for pain (gch1 and mthfr)
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
01 Apr. 2015, 31 Mar. 2018

Neuron-specific mechanism for production and secretion of amyloid-beta and therapeutic regulation of its deposition
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
01 Apr. 2014, 31 Mar. 2017

Analgesic mechanism of tetrabiopterin and cholinergic metabolism inhibitors
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
01 Apr. 2012, 31 Mar. 2015

Study on analgesic mechanism of GCH1 inhibitor
Grant-in-Aid for Young Scientists (B)
Shiga University of Medical Science
2010, 2011

Cholinergic regulation of nociception in dorsal root ganglion
Grant-in-Aid for Young Scientists (B)
Shiga University of Medical Science
2008, 2009

麻酔による睡眠障害に関する生理学的および分子生物学的研究・・・周術期合併症の軽減とQuality of Anesthesiaの向上をめざして・・・
萌芽研究
滋賀医科大学
2002, 2004

STUDY ON THE BIOCHEMISTRY OF NEUROTRANSMITTER SYNTHEZING ENZYME.