Amyloid-β1-42 oligomers compromise oligodendrocyte precursor cells and disrupt blood-brain barrier integrity in vitro.
Masaru Toyokawa; Ken Yasuda; Akihiro Kikuya; Megumi Asada-Utsugi; Misaki Hida; Yamato Nakamura; Narufumi Yanagida; Shintaro Toda; Seiji Kaji; Yusuke Kinoshita; Yuichi Ono; Ryosuke Takahashi; Riki Matsumoto; Ayae Kinosita; Takakuni Maki
Brain research, 19 Jun. 2026

Amyloidogenic and non-amyloidogenic pathways of amyloid precursor protein processing in oligodendrocytes.
Misaki Hida; Ken Yasuda; Masaru Toyokawa; Megumi Asada-Utsugi; Shintaro Toda; Narufumi Yanagida; Ryosuke Takahashi; Ayae Kinoshita; Takakuni Maki
Brain research, 15 May 2025, Refereed

The association of hemopexin, muscle quality, and sarcopenia in Japanese older adults with cognitive impairment: a cross-sectional study.
Derong Zeng; Kaoru Mizutani; Xiang Qi; Megumi Asada-Utsugi; Bei Wu; Teruaki Kawasaki; Ichiro Akiguchi; Ayae Kinoshita
BMC geriatrics, 13 May 2025, Refereed

Tau beyond Tangles: DNA Damage Response and Cytoskeletal Protein Crosstalk on Neurodegeneration
Megumi Asada-Utsugi; Makoto Urushitani
International Journal of Molecular Sciences, 19 Jul. 2024, Refereed, Invited, Lead, URL

In vivo analysis of aggregation propensity of low levels of mislocalized TDP-43 on cytopathological and behavioral phenotype of ALS/FTLD.
Hideki Wada; Ryota Hikiami; Makiko Kusui; Sumio Minamiyama; Megumi Asada-Utsugi; Akemi Shodai; Shin-Ichi Muramatsu; Toshifumi Morimura; Makoto Urushitani
Neuroscience research, 16 Feb. 2023, Refereed

Efficacy of oligodendrocyte precursor cells as delivery vehicles for single-chain variable fragment to misfolded SOD1 in ALS rat model
Sumio Minamiyama; Madoka Sakai; Yuko Yamaguchi; Makiko Kusui; Hideki Wada; Ryota Hikiami; Yoshitaka Tamaki; Megumi Asada-Utsugi; Akemi Shodai; Akiko Makino; Noriko Fujiwara; Takashi Ayaki; Takakuni Maki; Hitoshi Warita; Masashi Aoki; Keizo Tomonaga; Ryosuke Takahashi; Makoto Urushitani
Molecular Therapy - Methods & Clinical Development, Feb. 2023, Refereed

Conformational change of RNA-helicase DHX30 by ALS/FTD-linked FUS induces mitochondrial dysfunction and cytosolic aggregates.
Ryota Hikiami; Toshifumi Morimura; Takashi Ayaki; Tomoyuki Tsukiyama; Naoko Morimura; Makiko Kusui; Hideki Wada; Sumio Minamiyama; Akemi Shodai; Megumi Asada-Utsugi; Shin-Ichi Muramatsu; Takatoshi Ueki; Ryosuke Takahashi; Makoto Urushitani
Scientific reports, 26 Sep. 2022, Refereed

Failure of DNA double-strand break repair by tau mediates Alzheimer’s disease pathology in vitro
Megumi Asada-Utsugi; Kengo Uemura; Takashi Ayaki; Maiko T. Uemura; Sumio Minamiyama; Ryota Hikiami; Toshifumi Morimura; Akemi Shodai; Takatoshi Ueki; Ryosuke Takahashi; Ayae Kinoshita; Makoto Urushitani
Communications Biology, Apr. 2022, Refereed, Lead

Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks.
M Asada-Utsugi; K Uemura; M Kubota; Y Noda; Y Tashiro; T M Uemura; H Yamakado; M Urushitani; R Takahashi; S Hattori; T Miyakawa; N Ageta-Ishihara; K Kobayashi; M Kinoshita; A Kinoshita
Molecular brain, 25 Jan. 2021, Refereed, Lead

血液脳関門におけるアミロイドβの病的意義の検討
豊川 勝; 眞木 崇州; 梶 誠兒; 田代 善崇; 安田 謙; 浅田 めぐみ; 高橋 良輔; 木下 彩栄
Dementia Japan, Oct. 2020, Refereed

Synaptic Vesicle Protein 2B Negatively Regulates the Amyloidogenic Processing of AβPP as a Novel Interaction Partner of BACE1.
Masakazu Miyamoto; Akira Kuzuya; Yasuha Noda; Sakiho Ueda; Megumi Asada-Utsugi; Shinji Ito; Yoshiyasu Fukusumi; Hiroshi Kawachi; Ryosuke Takahashi; Ayae Kinoshita
Journal of Alzheimer's disease : JAD, 2020, Refereed

血液脳関門におけるアミロイドβの病的意義の検討
豊川 勝; 眞木 崇州; 梶 誠兒; 田代 善崇; 浅田 めぐみ; 高橋 良輔; 木下 彩栄
Dementia Japan, Oct. 2019, Refereed

Two-Point Dynamic Observation of Alzheimer's Disease Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus.
Naoto Jingami; Kengo Uemura; Megumi Asada-Utsugi; Akira Kuzuya; Shigeki Yamada; Masatsune Ishikawa; Takashi Kawahara; Takuya Iwasaki; Masamichi Atsuchi; Ryosuke Takahashi; Ayae Kinoshita
Journal of Alzheimer's disease : JAD, 2019, Refereed

外来蛋白質を持続発現するボルナウイルスベクターの新たなアルツハイマー病治療戦略
上田 紗希帆; 酒井 まどか; 大東 卓史; 浅田 めぐみ; 小松 弓子; 眞木 崇州; 葛谷 聡; 木下 彩栄; 高橋 良輔; 牧野 晶子; 朝長 啓造
Dementia Japan, Sep. 2018, Refereed

Degradation of amyloid β peptide by neprilysin expressed from Borna disease virus vector.
Madoka Sakai; Sakiho Ueda; Takuji Daito; Megumi Asada-Utsugi; Yumiko Komatsu; Ayae Kinoshita; Takakuni Maki; Akira Kuzuya; Ryosuke Takahashi; Akiko Makino; Keizo Tomonaga
Microbiology and immunology, 17 May 2018, Refereed

タップテストでの脳脊髄液バイオマーカーの動的モニタリング
植村 健吾; 陣上 直人; 葛谷 聡; 浅田 めぐみ; 山田 茂樹; 川原 隆; 岩崎 琢也; 厚地 正道; 石川 正恒; 高橋 良輔; 木下 彩栄
Dementia Japan, Oct. 2017, Refereed

日本初のAARS複合ヘテロ変異を認めた白質ジストロフィー
陣上 直人; 濱谷 美緒; 鶴崎 美徳; 島田 姿野; 下島 圭子; 浅田 めぐみ; 吉永 健二; 上村 紀人; 山下 博文; 植村 健吾; 松本 直通; 山本 俊至; 高橋 良輔
Dementia Japan, Oct. 2017, Refereed

The first Japanese case of leukodystrophy with ovarian failure arising from novel compound heterozygous AARS2 mutations.
Mio Hamatani; Naoto Jingami; Yoshinori Tsurusaki; Shino Shimada; Keiko Shimojima; Megumi Asada-Utsugi; Kenji Yoshinaga; Norihito Uemura; Hirofumi Yamashita; Kengo Uemura; Ryosuke Takahashi; Naomichi Matsumoto; Toshiyuki Yamamoto
Journal of human genetics, Oct. 2016, Refereed

The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease.
Kiwamu Watanabe; Kengo Uemura; Megumi Asada; Masato Maesako; Haruhiko Akiyama; Shun Shimohama; Ryosuke Takahashi; Ayae Kinoshita
Molecular brain, 04 Dec. 2015, Refereed

Idiopathic normal pressure hydrocephalus has a different cerebrospinal fluid biomarker profile from Alzheimer's disease.
Naoto Jingami; Megumi Asada-Utsugi; Kengo Uemura; Rio Noto; Makio Takahashi; Akihiko Ozaki; Takeshi Kihara; Takashi Kageyama; Ryosuke Takahashi; Shun Shimohama; Ayae Kinoshita
Journal of Alzheimer's disease : JAD, 2015, Refereed

High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.
Masato Maesako; Maiko Uemura; Yoshitaka Tashiro; Kazuki Sasaki; Kiwamu Watanabe; Yasuha Noda; Karin Ueda; Megumi Asada-Utsugi; Masakazu Kubota; Katsuya Okawa; Masafumi Ihara; Shun Shimohama; Kengo Uemura; Ayae Kinoshita
PloS one, 2015, Refereed

正常圧水頭症における髄液マーカー Tau、Amyloidβ、AQP1、LRGの比較検討
陣上 直人; 植村 健吾; 能登 理央; 浅田 めぐみ; 高橋 牧郎; 尾崎 彰彦; 木原 武士; 景山 卓; 木下 彩栄; 高橋 良輔
臨床神経学, Dec. 2013, Refereed

正常圧水頭症はアルツハイマー病と異なるバイオマーカープロファイルを持つ疾患である
陣上 直人; 植村 健吾; 浅田 めぐみ; 上田 紗希帆; 宮本 将和; 高橋 牧郎; 尾崎 彰彦; 木下 彩栄; 高橋 良輔
Dementia Japan, Oct. 2013, Refereed

Copper enhances APP dimerization and promotes Aβ production.
Yasuha Noda; Megumi Asada; Masakazu Kubota; Masato Maesako; Kiwamu Watanabe; Maiko Uemura; Takeshi Kihara; Shun Shimohama; Ryosuke Takahashi; Ayae Kinoshita; Kengo Uemura
Neuroscience letters, 28 Jun. 2013, Refereed

Continuation of exercise is necessary to inhibit high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice.
Masato Maesako; Kengo Uemura; Ayana Iwata; Masakazu Kubota; Kiwamu Watanabe; Maiko Uemura; Yasuha Noda; Megumi Asada-Utsugi; Takeshi Kihara; Ryosuke Takahashi; Shun Shimohama; Ayae Kinoshita
PloS one, 2013, Refereed

Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice.
Masato Maesako; Kengo Uemura; Masakazu Kubota; Akira Kuzuya; Kazuki Sasaki; Naoko Hayashida; Megumi Asada-Utsugi; Kiwamu Watanabe; Maiko Uemura; Takeshi Kihara; Ryosuke Takahashi; Shun Shimohama; Ayae Kinoshita
The Journal of biological chemistry, 29 Jun. 2012, Refereed

Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling.
Masato Maesako; Kengo Uemura; Akira Kuzuya; Kazuki Sasaki; Megumi Asada; Kiwamu Watanabe; Koichi Ando; Masakazu Kubota; Haruhiko Akiyama; Ryosuke Takahashi; Takeshi Kihara; Shun Shimohama; Ayae Kinoshita
Journal of neurochemistry, Jun. 2012, Refereed

Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice.
Masato Maesako; Kengo Uemura; Masakazu Kubota; Akira Kuzuya; Kazuki Sasaki; Megumi Asada; Kiwamu Watanabe; Naoko Hayashida; Masafumi Ihara; Hidefumi Ito; Shun Shimohama; Takeshi Kihara; Ayae Kinoshita
Neurobiology of aging, May 2012, Refereed

N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production.
Megumi Asada-Utsugi; Kengo Uemura; Yasuha Noda; Akira Kuzuya; Masato Maesako; Koichi Ando; Masakazu Kubota; Kiwamu Watanabe; Makio Takahashi; Takeshi Kihara; Shun Shimohama; Ryosuke Takahashi; Oksana Berezovska; Ayae Kinoshita
Journal of neurochemistry, Oct. 2011, Refereed, Lead

Presenilin regulates insulin signaling via a gamma-secretase-independent mechanism.
Masato Maesako; Kengo Uemura; Akira Kuzuya; Kazuki Sasaki; Megumi Asada; Kiwamu Watanabe; Koichi Ando; Masakazu Kubota; Takeshi Kihara; Ayae Kinoshita
The Journal of biological chemistry, 15 Jul. 2011, Refereed

Effect of glycogen synthase kinase 3 β-mediated presenilin 1 phosphorylation on amyloid β production is negatively regulated by insulin receptor cleavage.
Maesako M; Uemura K; Kubota M; Hiyoshi K; Ando K; Kuzuya A; Kihara T; Asada M; Akiyama H; Kinoshita A
Neuroscience, 17 Mar. 2011

N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease.
Koichi Ando; Kengo Uemura; Akira Kuzuya; Masato Maesako; Megumi Asada-Utsugi; Masakazu Kubota; Nobuhisa Aoyagi; Katsuji Yoshioka; Katsuya Okawa; Haruhisa Inoue; Jun Kawamata; Shun Shimohama; Tetsuaki Arai; Ryosuke Takahashi; Ayae Kinoshita
The Journal of biological chemistry, 04 Mar. 2011, Refereed

Environmental Enrichment ameliorates high fat diet induced memory deficit and beta-amyloidosis
Masato Maesako; Kazuki Sasaki; Akira Kuzuya; Megumi Asada; Masakazu Kubota; Koichi Ando; Masafumi Ihara; Hidefumi Ito; Takeshi Kihara; Kengo Uemura; Ayae Kinoshita
NEUROSCIENCE RESEARCH, 2011, Refereed, Not invited

Insulin regulates Presenilin 1 localization via PI3K/Akt signaling.
Masato Maesako; Kengo Uemura; Masakazu Kubota; Koichi Ando; Akira Kuzuya; Megumi Asada; Takeshi Kihara; Ayae Kinoshita
Neuroscience letters, 15 Oct. 2010, Refereed

Effects of presenilin 1 phosphorylation on insulin receptor
Masato Maesako; Kengo Uemura; Masakazu Kubota; Koichi Ando; Akira Kuzuya; Megumi Asada; Nao Yamada; Haruhiko Akiyama; Ayae Kinoshita
NEUROSCIENCE RESEARCH, 2010, Refereed, Not invited

Analysis of N-cadherin interacting proteins in Alzheimer's disease
Ando Koichi; Watanabe Kiwamu; Maesako Masato; Asada Megumi; Kubota Masakazu; Aoyagi Nobuhisa; Kuzuya Akira; Uemura Kengo; Kawamata Jun; Takahashi Ryosuke; Kinoshita Ayae
NEUROSCIENCE RESEARCH, 2010, Refereed, Not invited

Chronic cerebral hypoperfusion accelerates amyloid beta deposition in APPSwInd transgenic mice.
Hiroshi Kitaguchi; Hidekazu Tomimoto; Masafumi Ihara; Masunari Shibata; Kengo Uemura; Rajesch N Kalaria; Takeshi Kihara; Megumi Asada-Utsugi; Ayae Kinoshita; Ryosuke Takahashi
Brain research, 19 Oct. 2009, Refereed

Functional regulation of Presenilin1 via insulin signaling
Masato Maesako; Kengo Uemura; Masakazu Kubota; Akira Kuzuya; Koichi Ando; Takeshi Ikeuchi; Megumi Asada; Ayae Kinoshita
NEUROSCIENCE RESEARCH, 2009, Refereed, Not invited

N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio.
Kengo Uemura; Christina M Lill; Mary Banks; Megumi Asada; Nobuhisa Aoyagi; Koichi Ando; Masakazu Kubota; Takeshi Kihara; Takaaki Nishimoto; Hachiro Sugimoto; Ryosuke Takahashi; Bradley T Hyman; Shun Shimohama; Oksana Berezovska; Ayae Kinoshita
Journal of neurochemistry, Jan. 2009, Refereed

Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening.
Masaki Sone; Atsuko Uchida; Ayumi Komatsu; Emiko Suzuki; Ikue Ibuki; Megumi Asada; Hiroki Shiwaku; Takuya Tamura; Mikio Hoshino; Hitoshi Okazawa; Yo-ichi Nabeshima
PloS one, 2009, Refereed

【タウ研究update】神経細胞におけるDNA二本鎖切断修復不全とタウ病理 タウの新たな生理機能の発見
浅田 めぐみ[宇津木]; 柴田 淳史; 漆谷 真
Dementia Japan, Apr. 2024

シナプス小胞タンパク質2BはBACE1の新規相互作用タンパク質である(Synaptic vesicle protein 2B is a novel interaction partner of BACE1)
宮本 将和; 葛谷 聡; 野田 泰葉; 上田 紗希帆; 浅田 めぐみ[宇津木]; 伊藤 慎二; 福住 好恭; 河内 裕; 高橋 良輔; 木下 彩栄
Dementia Japan, Oct. 2020

SV2AではなくSV2Bが負のレギュレーターとしてBACE1と相互作用することが好ましい(SV2B rather than SV2A preferably interacts with BACE1 as its negative regulator)
宮本 将和; 葛谷 聡; 野田 泰葉; 植村 健吾; 浅田 めぐみ[宇津木]; 伊藤 慎二; 福住 好恭; 河内 裕; 高橋 良輔; 木下 彩栄
Dementia Japan, Oct. 2019

アルツハイマー病におけるTauのDNA損傷修復の阻害機構
浅田 めぐみ; 植村 健吾; 綾木 孝; 植木 孝俊; 高橋 良輔; 木下 彩栄; 漆谷 真
Dementia Japan, Oct. 2019, Not refereed, Not invited

アストロサイトから放出されるIGFBP-3とアルツハイマー病の病態生理の関連
渡邉 究; 浅田 めぐみ; 前迫 真人; 上村 麻衣子; 久保田 正和; 木原 武士; 秋山 治彦; 下濱 俊; 植村 健吾; 高橋 良輔; 木下 彩栄
臨床神経学, Dec. 2014, Not refereed, Not invited

Analysis of N-cadherin shedding deficient knock-in mice
Ayumi Suwa; Masakazu Kubota; Yoshitaka Tashiro; Masato Maesako; Megumi Asada; Kengo Uemura; Ayae Kinoshita
NEUROSCIENCE RESEARCH, 2011, Not refereed, Not invited

Investigating the pathology of Alzheimer's disease related to calcineurin in astrocytes
Kiwamu Watanabe; Masato Maesako; Megumi Asada; Akira Kuzuya; Kengo Uemura; Haruhiko Akiyama; Ryosuke Takahashi; Ayae Kinoshita
NEUROSCIENCE RESEARCH, 2011, Not refereed, Not invited

The effect of N-cadherin/Nectin-1 expression on APP cis-dimerization
Megumi Asada; Kengo Uemura; Akira Kuzuya; Nao Yamada; Masato Maesako; Kiwamu Watanabe; Koichi Ando; Oksana Berezovska; Bradley T. Hyman; Ryosuke Takahashi; Ayae Kinoshita
NEUROSCIENCE RESEARCH, 2010, Not refereed, Not invited

Analysis of N-cadherin interacting proteins in Alzheimer diesase
Koichi Ando; Masato Maesako; Megumi Asada; Masakazu Kubota; Nobuhisa Aoyagi; Akira Kuzuya; Kengo Uemura; Jun Kawamata; Ryosuke Takahashi; Ayae Kinosita
NEUROSCIENCE RESEARCH, 2009, Not refereed, Not invited

Effects of N-cadherin on APP homodimerization
Megumi Asada; Kengo Uemura; Akira Kuzuya; Masakazu Kubota; Shun Shimohama; Ryosuke Takahashi; Ayae Kinoshita
NEUROSCIENCE RESEARCH, 2009, Not refereed, Not invited

Analysis of Tau pathology from a new viewpoint of DNA damage and cytoskeletal proteins.
Invited seminar at Radiation Institute for Science & Engineering, Prairie View A&M University, April 24, 2023, Prairie View, TX, USA, 24 Apr. 2024, Invited

タウ分子病理とDNA損傷修復機構の関連について
浅田めぐみ
第41回日本認知症学会学術集会 第37回日本老年精神医学会［合同開催］, 25 Nov. 2022, Not invited

シナプス結合は、APP ダイマー化を促進し、アミロイド産生を調節する
浅田めぐみ
分子生物学会年会, Dec. 2011, Not invited

脊髄⼩脳変性症におけるミスマッチ修復因⼦を標的としたASO治療の開発
Apr. 2026, Mar. 2027

タウオパチーにおける二本鎖DNA損傷修復の破綻とNFT形成メカニズムの解明
若手研究
滋賀医科大学
Apr. 2023, Mar. 2026