SARS-CoV-2感染非ヒト霊長類における嗅上皮の変化と嗅神経を介した頭蓋内感染の可能性
清水 猛史; 清水 志乃; 仲山 美沙子; 石垣 宏仁; Nguyen Thanh Cong; 北川 善紀; 伊藤 靖
耳鼻咽喉科ニューロサイエンス, May 2024

Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection in cynomolgus macaque
Cong Thanh Nguyen; Misako Nakayama; Hirohito Ishigaki; Yoshinori Kitagawa; Akemi Kakino; Marumi Ohno; Masashi Shingai; Yasuhiko Suzuki; Tatsuya Sawamura; Hiroshi Kida; Yasushi Itoh
Virology, Mar. 2024

SARS-CoV-2 induces inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway in non-human primates
Shino Shimizu; Misako Nakayama; Cong Thanh Nguyen; Hirohito Ishigaki; Yoshinori Kitagawa; Fumihiko Yasui; Yoshiki Yagi; Tomoe Kusayanagi; Michinori Kohara; Yasushi Itoh; Ichiro Tojima; Hideaki Kouzaki; Takeshi Shimizu
Journal of Neuroimmunology, Jan. 2024, Refereed

Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19.
Eri Kawakami; Norikazu Saiki; Yosuke Yoneyama; Chiharu Moriya; Mari Maezawa; Shuntaro Kawamura; Akiko Kinebuchi; Tamaki Kono; Masaaki Funata; Ayaka Sakoda; Shigeru Kondo; Takeshi Ebihara; Hisatake Matsumoto; Yuki Togami; Hiroshi Ogura; Fuminori Sugihara; Daisuke Okuzaki; Takashi Kojima; Sayaka Deguchi; Sebastien Vallee; Susan McQuade; Rizwana Islam; Madhusudan Natarajan; Hirohito Ishigaki; Misako Nakayama; Cong Thanh Nguyen; Yoshinori Kitagawa; Yunheng Wu; Kensaku Mori; Takayuki Hishiki; Tomohiko Takasaki; Yasushi Itoh; Kazuo Takayama; Yasunori Nio; Takanori Takebe
Cell stem cell, 05 Oct. 2023

Suppression of viral RNA polymerase activity is necessary for persistent infection during the transformation of measles virus into SSPE virus
Kento Sakamoto; Miho Konami; Shinra Kameda; Yuto Satoh; Hiroshi Wakimoto; Yoshinori Kitagawa; Bin Gotoh; Da-Peng Jiang; Hak Hotta; Masae Itoh
PLOS Pathogens, 26 Jul. 2023, Refereed, URL

「感染・免疫研究の新潮流」 非ヒト霊長類の嗅上皮から嗅球におけるSARS-CoV-2感染の病態
清水 志乃; 仲山 美沙子; 石垣 宏仁; Nguyen Thanh Cong; 北川 善紀; 伊藤 靖; 清水 猛史
日本耳鼻咽喉科免疫アレルギー感染症学会抄録集, Mar. 2023

Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models
Masaru Takeshita; Hidehiro Fukuyama; Katsuhiko Kamada; Takehisa Matsumoto; Chieko Makino-Okamura; Tomomi Uchikubo-Kamo; Yuri Tomabechi; Kazuharu Hanada; Saya Moriyama; Yoshimasa Takahashi; Hirohito Ishigaki; Misako Nakayama; Cong Thanh Nguyen; Yoshinori Kitagawa; Yasushi Itoh; Masaki Imai; Tadashi Maemura; Yuri Furusawa; Hiroshi Ueki; Kiyoko Iwatsuki-Horimoto; Mutsumi Ito; Seiya Yamayoshi; Yoshihiro Kawaoka; Mikako Shirouzu; Makoto Ishii; Hideyuki Saya; Yasushi Kondo; Yuko Kaneko; Katsuya Suzuki; Koichi Fukunaga; Tsutomu Takeuchi
iScience, Dec. 2022

An attenuated vaccinia vaccine encoding the severe acute respiratory syndrome coronavirus-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human angiotensin-converting enzyme 2 transgenic mice from severe acute respiratory syndrome coronavirus-2 and its variants
Hirohito Ishigaki; Fumihiko Yasui; Misako Nakayama; Akinori Endo; Naoki Yamamoto; Kenzaburo Yamaji; Cong Thanh Nguyen; Yoshinori Kitagawa; Takahiro Sanada; Tomoko Honda; Tsubasa Munakata; Masahiko Higa; Sakiko Toyama; Risa Kono; Asako Takagi; Yusuke Matsumoto; Aya Koseki; Kaori Hayashi; Masanori Shiohara; Koji Ishii; Yasushi Saeki; Yasushi Itoh; Michinori Kohara
Frontiers in Microbiology, 18 Nov. 2022, Refereed, Not invited

サルにおける嗅上皮から嗅神経を介したSARS-CoV-2の頭蓋内感染について
清水 志乃; 仲山 美沙子; 石垣 宏仁; Nguyen Thanh Cong; 北川 善紀; 伊藤 靖; 清水 猛史
日本鼻科学会会誌, Oct. 2022

Middle East respiratory syndrome coronavirus ORF4b protein inhibits TLR7 ‐ and TLR9 ‐dependent alpha interferon induction
Yoshinori Kitagawa; Takumi Tsukamoto; Masae Itoh; Bin Gotoh
FEBS Letters, Oct. 2022, Refereed, Lead, URL

Human metapneumovirus M2-2 protein inhibits RIG-I signaling by preventing TRIM25-mediated RIG-I ubiquitination
Yukie Tanaka; Naoko Morita; Yoshinori Kitagawa; Bin Gotoh; Takayuki Komatsu
Frontiers in Immunology, 15 Aug. 2022, Refereed, URL

Upregulation of viral RNA polymerase activity promotes adaptation of SSPE virus to neuronal cells
Kento Sakamoto; Yuto Satoh; Ken-ichi Takahashi; Hiroshi Wakimoto; Yoshinori Kitagawa; Bin Gotoh; Minoru Ayata; Masae Itoh
Virology, Aug. 2022

An attenuated vaccinia vaccine encoding the SARS-CoV-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human ACE2 transgenic mice from SARS-CoV-2 and its variants
Hirohito Ishigaki; Fumihiko Yasui; Misako Nakayama; Akinori Endo; Naoki Yamamoto; Kenzaburo Yamaji; Cong Thanh Nguyen; Yoshinori Kitagawa; Takahiro Sanada; Tomoko Honda; Tsubasa Munakata; Masahiko Higa; Sakiko Toyama; Risa Kono; Asako Takagi; Yusuke Matsumoto; Kaori Hayashi; Masanori Shiohara; Koji Ishii; Yasushi Saeki; Yasushi Itoh; Michinori Kohara
13 Jun. 2022, Not refereed, Not invited, URL

SeV C Protein Plays a Role in Restricting Macrophage Phagocytosis by Limiting the Generation of Intracellular Double-Stranded RNA
Naoko Morita; Yukie Tanaka; Kenji Takeuchi; Yoshinori Kitagawa; Ryusuke Sakuma; Naoki Koide; Takayuki Komatsu
Frontiers in Microbiology, 2022, Refereed

M protein of subacute sclerosing panencephalitis virus, synergistically with the F protein, plays a crucial role in viral neuropathogenicity
Yuto Satoh; Kurara Higuchi; Daichi Nishikawa; Hiroshi Wakimoto; Miho Konami; Kento Sakamoto; Yoshinori Kitagawa; Bin Gotoh; Da-Peng Jiang; Hak Hotta; Masae Itoh
Journal of General Virology, 2021, Refereed, URL

Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques
Hirohito Ishigaki; Misako Nakayama; Yoshinori Kitagawa; Cong Thanh Nguyen; Kaori Hayashi; Masanori Shiohara; Bin Gotoh; Yasushi Itoh
Virology, 2021, Refereed

Respirovirus C protein inhibits activation of type I interferon receptor‐associated kinases to block JAK‐STAT signaling
Yoshinori Kitagawa; Mayu Yamaguchi; Miki Kohno; Madoka Sakai; Masae Itoh; Bin Gotoh
FEBS Letters, Mar. 2020, Refereed, Lead, URL

Sendai Virus V Protein Inhibits the Secretion of Interleukin-1β by Preventing NLRP3 Inflammasome Assembly.
Komatsu T; Tanaka Y; Kitagawa Y; Koide N; Naiki Y; Morita N; Gotoh B; Yokochi T
Journal of Virology, Jul. 2018, Refereed, Not invited

Nonstructural protein of severe fever with thrombocytopenia syndrome phlebovirus targets STAT2 and not STAT1 to inhibit type I interferon-stimulated JAK-STAT signaling
Yoshinori Kitagawa; Madoka Sakai; Masayuki Shimojima; Masayuki Saijo; Masae Itoh; Bin Gotoh
Microbes and Infection, 2018, Refereed, Not invited, Lead

Human Metapneumovirus M2-2 Protein Acts as a Negative Regulator of Alpha Interferon Production by Plasmacytoid Dendritic Cells
Yoshinori Kitagawa; Madoka Sakai; Mariko Funayama; Masae Itoh; Bin Gotoh
JOURNAL OF VIROLOGY, Oct. 2017, Refereed, Not invited

Induction of necroptotic cell death by viral activation of the RIG-I or STING pathway
Suruchi N. Schock; Neha V. Chandra; Yuefang Sun; Takashi Irie; Yoshinori Kitagawa; Bin Gotoh; Laurent Coscoy; Astar Winoto
CELL DEATH AND DIFFERENTIATION, Apr. 2017, Refereed, Not invited

A residue located at the junction of the head and stalk regions of measles virus fusion protein regulates membrane fusion by controlling conformational stability
Yuto Satoh; Saeka Yonemori; Mitsuhiro Hirose; Hiroko Shogaki; Hiroshi Wakimoto; Yoshinori Kitagawa; Bin Gotoh; Tsuyoshi Shirai; Ken-ichi Takahashi; Masae Itoh
JOURNAL OF GENERAL VIROLOGY, Feb. 2017, Refereed, Not invited

Intramolecular complementation of measles virus fusion protein stability confers cell-cell fusion activity at 37 degrees C
Yuto Satoh; Mitsuhiro Hirose; Hiroko Shogaki; Hiroshi Wakimoto; Yoshinori Kitagawa; Bin Gotoh; Ken-ichi Takahashi; Masae Itoh
FEBS LETTERS, Jan. 2015, Refereed, Not invited

An anti-interferon activity shared by paramyxovirus C proteins: Inhibition of Toll-like receptor 7/9-dependent alpha interferon induction
Mayu Yamaguchi; Yoshinori Kitagawa; Min Zhou; Masae Itoh; Bin Gotoh
FEBS LETTERS, Jan. 2014, Refereed, Not invited

Human Parainfluenza Virus Type 2 V Protein Inhibits TRAF6-Mediated Ubiquitination of IRF7 To Prevent TLR7-and TLR9-Dependent Interferon Induction
Yoshinori Kitagawa; Mayu Yamaguchi; Min Zhou; Machiko Nishio; Masae Itoh; Bin Gotoh
JOURNAL OF VIROLOGY, Jul. 2013, Refereed, Not invited

F-Actin Modulates Measles Virus Cell-Cell Fusion and Assembly by Altering the Interaction between the Matrix Protein and the Cytoplasmic Tail of Hemagglutinin
Hiroshi Wakimoto; Masakatsu Shimodo; Yuto Satoh; Yoshinori Kitagawa; Kaoru Takeuchi; Bin Gotoh; Masae Itoh
JOURNAL OF VIROLOGY, Feb. 2013, Refereed, Not invited

Expeditious neutralization assay for human metapneumovirus based on a recombinant virus expressing Renilla luciferase
Min Zhou; Yoshinori Kitagawa; Mayu Yamaguchi; Chika Uchiyama; Masae Itoh; Bin Gotoh
Journal of Clinical Virology, Jan. 2013, Refereed, Not invited

A Tryptophan-Rich Motif in the Human Parainfluenza Virus Type 2 V Protein Is Critical for the Blockade of Toll-Like Receptor 7 (TLR7)- and TLR9-Dependent Signaling
Yoshinori Kitagawa; Mayu Yamaguchi; Min Zhou; Takayuki Komatsu; Machiko Nishio; Tsuyoshi Sugiyama; Kenji Takeuchi; Masae Itoh; Bin Gotoh
JOURNAL OF VIROLOGY, May 2011, Refereed, Not invited

Human metapneumovirus M2-2 protein inhibits viral transcription and replication
Yoshinori Kitagawa; Min Zhou; Mayu Yamaguchi; Takayuki Komatsu; Kenji Takeuchi; Masae Itoh; Bin Gotoh
MICROBES AND INFECTION, Feb. 2010, Refereed, Not invited

Covalent bonded Gag multimers in human immunodeficiency virus type-1 particles
Yoshinori Kitagawa; Masae Maeda-Sato; Keiko Tanaka; Minoru Tobiume; Hirofumi Sawa; Hideki Hasegawa; Asato Kojima; William W. Hall; Takeshi Kurata; Tetsutaro Sata; Hidehiro Takahashi
MICROBIOLOGY AND IMMUNOLOGY, Nov. 2009, Refereed, Not invited

Monoclonal Antibody and siRNAs for Topoisomerase I Suppress Telomerase Activity
Hidehiro Takahashi; Yoshinori Kitagawa; Masae Maeda-Satoh; Hideki Hasegawa; Hirofumi Sawa; Tetsutaro Sata
HYBRIDOMA, Feb. 2009, Refereed, Not invited

Sendai Virus C Protein Plays a Role in Restricting PKR Activation by Limiting the Generation of Intracellular Double-Stranded RNA
Kenji Takeuchi; Takayuki Komatsu; Yoshinori Kitagawa; Kiyonao Sada; Bin Gotoh
JOURNAL OF VIROLOGY, Oct. 2008, Refereed, Not invited

Ligand-directed gene targeting to mammalian cells by pseudotype baculoviruses
Y Kitagawa; H Tani; C Kwang; LTM Matsunaga; K Moriishi; Y Matsuura
JOURNAL OF VIROLOGY, Mar. 2005, Refereed, Not invited

In vitro and in vivo gene delivery by recombinant baculoviruses
H Tani; CK Limn; CC Yap; M Onishi; M Nozaki; Y Nishimune; N Okahashi; Y Kitagawa; R Watanabe; R Mochizuki; K Moriishi; Y Matsuura
JOURNAL OF VIROLOGY, Sep. 2003, Refereed, Not invited

Identification of receptors for pig endogenous retrovirus
TA Ericsson; Y Takeuchi; C Templin; G Quinn; SF Farhadian; JC Wood; BA Oldmixon; KM Suling; JK Ishii; Y Kitagawa; T Miyazawa; DR Salomon; RA Weiss; C Patience
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2003, Refereed, Not invited

Monoclonal antibodies against topoisomerase I suppressed DNA relaxation and HIV-1 cDNA synthesis
H Takahashi; T Iwata; Y Kitagawa; Y Shoya; RH Takahashi; K Nagashima; T Kurata
HYBRIDOMA, Aug. 2000, Refereed, Not invited

Increased levels of epsilon and gamma isoforms of 14-3-3 proteins in cerebrospinal fluid in patients with Creutzfeldt-Jakob disease
H Takahashi; T Iwata; Y Kitagawa; RH Takahashi; Y Sato; H Wakabayashi; M Takashima; H Kido; K Nagashima; K Kenney; CJ Gibbs; T Kurata
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, Nov. 1999, Refereed, Not invited

サルにおける嗅上皮から嗅神経を介したSARS-CoV-2の頭蓋内感染について
清水 志乃; 仲山 美沙子; 石垣 宏仁; Nguyen Thanh Cong; 北川 善紀; 伊藤 靖; 清水 猛史
日本鼻科学会会誌, Oct. 2022

サルにおける嗅上皮から嗅神経を介したSARS-CoV-2の頭蓋内感染について
清水志乃; 仲山美沙子; 石垣宏仁; NGUYEN Thanh Cong; 北川善紀; 伊藤靖; 清水猛史
日本鼻科学会会誌(Web), 2022

高度弱毒化ワクシニアウイルスベクターDIsを用いたCOVID-19ワクチンの交差反応性と長期免疫持続効果の検討
安井文彦; 松本祐介; 石垣宏仁; 仲山美沙子; 山本直樹; 真田崇弘; 山地賢三郎; THANH Nguyen Cong; 本田智子; 北川善紀; 伊藤靖; 小原道法
日本ワクチン学会学術集会プログラム・抄録集, 2022

霊長類モデルを用いたインフルエンザとCOVID-19のワクチン開発
伊藤靖; 石垣宏仁; 仲山美沙子; NGUYEN Thanh Cong; 北川善紀; 安井文彦; 小原道法; 石井健; 新開大史; 迫田義博; 喜田宏
日本実験動物学会総会講演要旨集(Web), 2022

【ウイルスベクター 最新の話題】 バキュロウイルスベクター 哺乳動物細胞への遺伝子導入
谷 英樹; 阿部 隆之; 林 昌宏; 望月 理加; 山岸 潤也; 北川 善紀; 渡辺 理恵; 宮本 大伸; 森石 恆司; 松浦 善治
ウイルス, Dec. 2003, Not refereed, Not invited

Baculovirus vector--gene transfer into mammalian cells
Hideki Tani; Takayuki Abe; Chang Kwang Limn; Rika Mochizuki; Junya Yamagishi; Yoshinori Kitagawa; Rie Watanabe; Kohji Moriishi; Yoshiharu Matsuura
Uirusu. Journal of virology, 2003, Not refereed, Not invited

病原体の世界 : 最小にして人類最大の宿敵 : 歴史をも動かすミクロの攻防
旦部, 幸博; 北川, 善紀
講談社, Aug. 2022
9784065290781

Microbiology
2022, Present, The University of Shiga Prefecture

Infectious Diseases and Immunology
2020, Present, Shiga University of Medical Science

微生物学（ウイルス学）
2019, Present, 滋賀医科大学

微生物学
2012, Present, 草津看護専門学校

微生物学実習
2006, Present, 滋賀医科大学

看護職リーダー養成プログラム
2021, 2022, 滋賀医科大学大学院

Microbiology
2015, 2021, The University of Shiga Prefecture

統合バイオテクノロジー特論
2018, 長浜バイオ大学大学院

American Society for Microbiology

日本ウイルス学会

新興ヘニパウイルスの免疫回避能とそれに基づく新規ワクチンの研究
基盤研究(C)
滋賀医科大学
Apr. 2023, Mar. 2026

中東呼吸器症候群コロナウイルスの免疫回避機構の解明とそれに基づく新規ワクチン開発
基盤研究(C)
滋賀医科大学
01 Apr. 2020, 31 Mar. 2023

抗ウイルス活性を呈する化学修飾核酸医薬の創薬に関する研究
共同研究
Sep. 2020, Sep. 2022

Molecular mechanism for the inhibition of TLR7/9-dependent signaling pathway by human metapneumovirus.
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
01 Apr. 2014, 31 Mar. 2017

Development of rapid neutralization assays and a primary transcription assay for human metapneumovirus
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
01 Apr. 2013, 31 Mar. 2016

Role of inhibitory activity of paramyxoviruses against host alpha-interferon production in virus pathogenicity
Grant-in-Aid for Young Scientists (B)
Shiga University of Medical Science
2011, 2013

Study on roles of human metapneumovirus accessory proteins in viral pathogenecity
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
2010, 2012

Host interferon system and antagonism of Nipah virus accessory protein.
Grant-in-Aid for Young Scientists (B)
Shiga University of Medical Science
2007, 2008

Human metapneumovirus pathogenicity and its interferon antagonism
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
2006, 2008

パラミクソウイルスのアクセサリー蛋白質の機能

パラミクソウイルスの自然免疫回避機構

特開WO/2023/199943, 特願PCT/JP2023/014855, ANTIBODY USED TO TREAT CORONAVIRUS INFECTION
SAITO Takashi; HARADA Michishige; SHIROUZU MikakoMATSUMOTO Takehisa; IDEI Akiko; INOUE Jun-ichiro; YAMAMOTO Mizuki; GOHDA Jin; KAWAGUCHI Yasushi; ITO Yasushi; ISHIGAKI Hirohito; NAKAYAMA Misako; KITAGAWA Yoshinori

特開WO/2022/065445, 特願PCT/JP2021/035159, SARS-CoV-2 NEUTRALIZING ANTIBODY OR FRAGMENT THEREOF
竹下勝; 竹内勤; 鈴木勝也; 佐谷秀行; 髙橋宜聖; 森山彩野; 福山英啓; 岡村千絵子; 白水美香子; 松本武久; 鎌田勝彦; 伊藤靖; 石垣宏仁; 仲山美沙子; 北川善紀; 河岡義裕; 棚井澄雄

特開WO/2022/025029, 特願PCT/JP2021/027662, METHOD FOR IN VITRO PROLIFERATING VIRUS BELONGING TO FAMILY CORONAVIRIDAE, METHOD FOR PRODUCING NEUTRALIZING ANTIBODY TO VIRUS BELONGING TO FAMILY CORONAVIRIDAE, AND METHOD FOR PRODUCING INFECTION MODEL OF SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2
伊藤 靖; 石垣宏仁; 仲山美沙子; 北川善紀