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OKAMOTO Keisei
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Researcher information

■ Degree
  • 医学博士, 京都大学
  • 医科学修士, 北海道大学
■ Field Of Study
  • Life sciences/Urology

Career

■ Educational Background
  • 1996
    Kyoto University, 医学研究科, 外科系泌尿器科
  • 1996
    Kyoto University, Graduate School, Division of Medicine
  • 1986
    Hokkaido University, School of Medicine
  • 1986
    Hokkaido University, Faculty of Medicine

Research activity information

■ Award
  • 平成16年度・高松宮妃癌研究基金研究助成、武田科学振興財団医学系研究奨励、平成11年度島津科学技術振興財団研究助成、上原記念生命科学財団研究助成、山之内病態代謝研究会研究助成
■ Paper
  • Magnetic Resonance Voiding Cystourethrography (MRVCUG): A Potential Alternative to Standard VCUG
    Kazuyoshi Johnin; Ryutaro Takazakura; Akira Furukawa; Keisei Okamoto; Yoshitaka Murakami; Kiyoshi Murata; Yusaku Okada
    JOURNAL OF MAGNETIC RESONANCE IMAGING, Oct. 2013, Not refereed, Not invited
  • Recurrent rhabdomyosarcoma after adjuvant chemotherapy for stageI non-seminomatous germ cell tumor with malignant transformation
    Hiroshi Ushida; Shuichi Koizumi; Kenjiro Katoh; Hidetoshi Okabe; Yusaku Okada; Keisei Okamoto
    International Journal of Urology, May 2013, Not refereed, Not invited
  • Stage C前立腺癌に対する内分泌ホルモン療法併用強度変調放射線治療(IMRT)の中期治療成績.
    河野 直明; 邵 啓全; 津川 拓也; 村田 喜代史; 野間 和夫; 本多 恵理子; 橋本 惠次; 近藤 康雄; 牛田 博; 岡本 圭生; 岡田 裕作
    滋賀医科大学雑誌, 2013, Not refereed, Not invited, URL
  • Pharmacokinetic/Pharmacodynamic analysis of a hemodialyzed patient treated with 25 mg of sunitinib
    Satoshi Noda; Susumu Kageyama; Teruhiko Tsuru; Shigehisa Kubota; Tetsuya Yoshida; Keisei Okamoto; Yusaku Okada; Shin-Ya Morita; Tomohiro Terada
    Case Reports in Oncology, Sep. 2012, Not refereed, Not invited
  • Methylation profile of DNA repetitive elements in human testicular germ cell tumor
    Hiroshi Ushida; Takahiro Kawakami; Kahori Minami; Tokuhiro Chano; Hidetoshi Okabe; Yusaku Okada; Keisei Okamoto
    MOLECULAR CARCINOGENESIS, Sep. 2012, Not refereed, Not invited
  • Therapeutic Potential of SOX2 Inhibition for Embryonal Carcinoma
    Hiroshi Ushida; Tokuhiro Chano; Kahori Minami; Hiroko Kita; Takahiro Kawakami; Hidetoshi Okabe; Yusaku Okada; Keisei Okamoto
    JOURNAL OF UROLOGY, May 2012, Not refereed, Not invited
  • Pharmacokinetic/Pharmacodynamic Analysis of a Hemodialyzed Patient Treated with 25 mg of Sunitinib.
    Case Rep Oncol, 2012, Not refereed, Not invited
  • 高リスクT1膀胱癌における術後膀胱内注入療法の検討.
    泌尿器科紀要, 2011, Not refereed, Not invited
  • A rare case of multiple schwannomas presenting with scrotal mass: A probable case of schwannomatosis
    Ryo Ikari; Keisei Okamoto; Tetsuya Yoshida; Kazuyoshi Johnin; Hidetoshi Okabe; Yusaku Okada
    INTERNATIONAL JOURNAL OF UROLOGY, Aug. 2010, Not refereed, Not invited
  • DNMT3L Is a Novel Marker and Is Essential for the Growth of Human Embryonal Carcinoma
    Kahori Minami; Tokuhiro Chano; Takahiro Kawakami; Hiroshi Ushida; Ryoji Kushima; Hidetoshi Okabe; Yusaku Okada; Keisei Okamoto
    CLINICAL CANCER RESEARCH, May 2010, Not refereed, Not invited
  • 限局性前立腺癌(高リスク群)に対する強度変調放射線治療(IMRT)の初期治療成績
    泌尿器科紀要, 2010, Not refereed, Not invited
  • Primary synovial sarcoma arising from a crossed ectopic kidney with fusion
    Susumu Kageyama; Teruhiko Tsuru; Keisei Okamoto; Mitsuhiro Narita; Yusaku Okada
    INTERNATIONAL JOURNAL OF UROLOGY, Jan. 2010, Not refereed, Not invited
  • Erasure of methylation imprint at the promoter and CTCF-binding site upstream of H19 in human testicular germ cell tumors of adolescents indicate their fetal germ cell origin
    T Kawakami; C Zhang; Y Okada; K Okamoto
    ONCOGENE, Jun. 2006, Not refereed, Not invited
  • Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma
    T Kawakami; T Chano; K Minami; H Okabe; Y Okada; K Okamoto
    HUMAN MOLECULAR GENETICS, Mar. 2006, Not refereed, Not invited
  • Distinctive epigenetic phenotype of cancer testis antigen genes among seminomatous and nonseminomatous testicular germ-cell tumors
    C Zhang; T Kawakami; Y Okada; K Okamoto
    GENES CHROMOSOMES & CANCER, May 2005, Not refereed, Not invited
  • Characterization of loss-of-inactive X in Klinefelter syndrome and female-derived cancer cells
    T Kawakami; C Zhang; T Taniguchi; CJ Kim; Y Okada; H Sugihara; T Hattori; AE Reeve; O Ogawa; K Okamoto
    ONCOGENE, Aug. 2004, Not refereed, Not invited
  • The MET proto-oncogene is not a major target for the gain of chromosome 7 in testicular germ-cell tumors of adolescents
    T Kawakami; K Okamoto; H Sugihara; T Hattori; AE Reeve; O Ogawa; Y Okada
    VIRCHOWS ARCHIV, May 2004, Not refereed, Not invited
  • XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer
    T Kawakami; K Okamoto; O Ogawa; Y Okada
    LANCET, Jan. 2004, Not refereed, Not invited
  • Multipoint methylation analysis indicates a distinctive epigenetic phenotype among testicular germ cell tumors and testicular malignant lymphomas
    T Kawakami; K Okamoto; A Kataoka; S Koizumi; H Iwaki; H Sugihara; AE Reeve; O Ogawa; Y Okada
    GENES CHROMOSOMES & CANCER, Sep. 2003, Not refereed, Not invited
  • The roles of supernumerical X chromosomes and XIST expression in testicular germ cell tumors
    T Kawakami; K Okamoto; H Sugihara; T Hattori; AE Reeve; O Ogawa; Y Okada
    JOURNAL OF UROLOGY, Apr. 2003, Not refereed, Not invited
  • Multipoint methylation and expression analysis of tumor suppressor genes in human renal cancer cells
    T Kawakami; K Okamoto; O Ogawa; Y Okada
    UROLOGY, Jan. 2003, Not refereed, Not invited
  • Expression patterns of cancer/testis antigens in testicular germ cell tumors and in adjacent testicular tissues
    J Urol, 2001, Not refereed, Not invited
  • Expression patterns of cancer/testis antigens in testicular germ cell tumors and in adjacent testicular tissues
    J Urol, 2001, Not refereed, Not invited
  • 自然腎出血を契機に発見された後天性腎嚢胞性疾患に合併した腎細胞癌の1例
    日本泌尿器科学会雑誌, 2000, Not refereed, Not invited
  • Is p57(KIP2) mutation a common mechanism for Beckwith-Wiedemann syndrome or somatic overgrowth?
    K Okamoto; IM Morison; AE Reeve; N Tommerup; HR Wiedemann; U Friedrich
    JOURNAL OF MEDICAL GENETICS, Jan. 1998, Not refereed, Not invited
  • Human p57(KIP2) defines a new imprinted domain on chromosome 11p but is not a tumour suppressor gene in Wilms tumour
    T Taniguchi; K Okamoto; AE Reeve
    ONCOGENE, Mar. 1997, Not refereed, Not invited
  • Epigenetic change at insulin-like growth factor II /H19 locus in developing kidney is an early event in Wilms tumourgenesis
    Proc Natl Acad Sci USA, 1997, Not refereed, Not invited
  • Epigenetic change at insulin-like growth factor II /H19 locus in developing kidney is an early event in Wilms tumourgenesis
    Proc Natl Acad Sci USA, 1997, Not refereed, Not invited
  • Induction of renal cell carcinoma in male Wistar rats treated with cupric nitrilotriacetate
    S Toyokuni; T Tanaka; Y Nishiyama; K Okamoto; Y Nakashima; S Hamazaki; S Okada; H Hiai
    LABORATORY INVESTIGATION, Aug. 1996, Not refereed, Not invited
  • Overexpression of human mutT homologue gene messenger RNA in renal-cell carcinoma: Evidence of persistent oxidative stress in cancer
    K Okamoto; S Toyokuni; WJ Kim; O Ogawa; Y Kakehi; S Arao; H Hiai; O Yoshida
    INTERNATIONAL JOURNAL OF CANCER, Feb. 1996, Not refereed, Not invited
  • Low incidence of point mutations in H-, K- and N-ras Oncogene and P53 tumor suppressor gene in renal cell carcinoma and peritoneal mesothelioma of Wistar rats induced by ferric nitrilotreacetate
    Jpn. J. Cancer Res, 1995, Not refereed, Not invited
  • Low incidence of point mutations in H-, K- and N-ras Oncogene and P53 tumor suppressor gene in renal cell carcinoma and peritoneal mesothelioma of Wistar rats induced by ferric nitrilotreacetate
    Jpn. J. Cancer Res, 1995, Not refereed, Not invited
  • PERSISTENT OXIDATIVE STRESS IN CANCER
    S TOYOKUNI; K OKAMOTO; J YODOI; H HIAI
    FEBS LETTERS, Jan. 1995, Not refereed, Not invited
  • FORMATION OF 8-HYDROXY-2'-DEOXYGUANOSINE AND 4-HYDROXY-2-NONENAL-MODIFIED PROTEINS IN HUMAN RENAL-CELL CARCINOMA
    K OKAMOTO; S TOYOKUNI; K UCHIDA; O OGAWA; J TAKENEWA; Y KAKEHI; H KINOSHITA; Y HATTORINAKAKUKI; H HIAI; O YOSHIDA
    INTERNATIONAL JOURNAL OF CANCER, Sep. 1994, Not refereed, Not invited
  • FORMATION OF 8-HYDROXY-2'-DEOXYGUANOSINE IN EPIDERMIS OF HAIRLESS MICE EXPOSED TO NEAR-UV
    Y HATTORINAKAKUKI; C NISHIGORI; K OKAMOTO; S IMAMURA; H HIAI; S TOYOKUNI
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 1994, Not refereed, Not invited
  • Formation of 4-hydroxy-2-nonenal modified proteins in the renal proxymal tubles of rats treated with a renal carcinogen, ferric nitrilotriacetate
    Proc Natl Acad Sci USA, 1994, Not refereed, Not invited
  • ABNORMAL BONE-MARROW B-CELL DIFFERENTIATION IN PRE-B LYMPHOMA-PRONE SL KH MICE
    K OKAMOTO; Y YAMADA; MS OGAWA; S TOYOKUNI; Y NAKAKUKI; H IKEDA; O YOSHIDA; H HIAI
    CANCER RESEARCH, Jan. 1994, Not refereed, Not invited
  • Formation of 4-hydroxy-2-nonenal modified proteins in the renal proxymal tubles of rats treated with a renal carcinogen, ferric nitrilotriacetate
    Proc Natl Acad Sci USA, 1994, Not refereed, Not invited
  • GENETIC PREDISPOSITION TO PRE-B LYMPHOMAS IN SL KH STRAIN MICE
    Y YAMADA; H MATSUSHIRO; MS OGAWA; K OKAMOTO; Y NAKAKUKI; S TOYOKUNI; M FUKUMOTO; H HIAI
    CANCER RESEARCH, Jan. 1994, Not refereed, Not invited
  • SL/KH STRAIN OF MICE - A MODEL OF SPONTANEOUS PRE-B-LYMPHOMAS
    MO SHIMADA; Y YAMADA; Y NAKAKUKI; K OKAMOTO; M FUKUMOTO; T HONJO; H HIAI
    LEUKEMIA RESEARCH, Jul. 1993, Not refereed, Not invited
  • 最近22年間の小児尿路結石の臨床的検討
    泌尿紀要, 1989, Not refereed, Not invited
■ MISC
  • Epigenetic profile of testicular germ cell tumours
    Keisei Okamoto; Takahiro Kawakami
    INTERNATIONAL JOURNAL OF ANDROLOGY, Aug. 2007, Not refereed, Not invited
  • Transitional cell carcinoma in a single ectopic ureter opening into the ejaculatory duct
    Urology, 2002, Not refereed, Not invited
  • Torsion of a spermatocele: A rare manifestation of the spermatocele
    Urol Int, 2002, Not refereed, Not invited
  • Transitional cell carcinoma in a single ectopic ureter opening into the ejaculatory duct
    NISHIKAWA Z
    Urology, 2002, Not refereed, Not invited
  • Torsion of a spermatocele: A rare manifestation of the spermatocele
    Urol Int, 2002, Not refereed, Not invited
  • Adenocarcinoma of the urachus associated with osseous metaplasia
    Urol Int, 1993, Not refereed, Not invited
  • Adenocarcinoma of the urachus associated with osseous metaplasia
    Urol Int, 1993, Not refereed, Not invited
  • 術前化学療法が奏効した腎盂尿管扁平上皮癌の1例.
    泌尿器外科, 1992, Not refereed, Not invited
  • 停留精巣固定術の長期予後成績
    泌尿紀要, 1992, Not refereed, Not invited
  • セフェム系抗生物質により血尿をきたしたと推察された1症例
    泌尿紀要, 1992, Not refereed, Not invited
  • 多剤併用療法が奏効した膀胱扁平上皮癌の1例.
    泌尿紀要, 1991, Not refereed, Not invited
■ Affiliated academic society
  • 日本泌尿器科学会
  • アメリカ癌学会
  • JUA
  • American Association of Cancer Research (AACR)
■ Research Themes
  • 腎癌の分子生物学的研究、腎細胞癌における新規癌抑制遺伝子の同定とその解析
  • 癌における不活化X染色体の喪失とその生物学的意義
  • 精巣腫瘍のエピジェネティックス解析とその臨床応用
  • Molecular Biology of Renal Cell Carcinomas (RCCs)、Identification and Study of novel tumor suppressor gene in RCCs
  • Loss of Inactive X chromosome in Cancer and Its Biological Significance
  • Study of Epigenetics in Testicular Germ Cell Tumors and Its Clinical Application