VR-based path integration predicts individual risk of rapid cortical decline: a one-year longitudinal study in cognitively unimpaired adults
Kazuya Kawabata; Sayuri Shima; Reiko Ohdake; Epifanio Bagarinao; Yasuaki Mizutani; Harutsugu Tatebe; Riki Koike; Atsushi Kasai; Akihiro Ueda; Mizuki Ito; Junichi Hata; Shinsuke Ishigaki; Hiroshi Toyama; Takahiko Tokuda; Akihiko Takashima; Hirohisa Watanabe
Alzheimer's Research & Therapy, 20 Apr. 2026, URL

Virtual reality navigation for the early detection of Alzheimer’s disease
Sayuri Shima; Reiko Ohdake; Yasuaki Mizutani; Harutsugu Tatebe; Riki Koike; Atsushi Kasai; Epifanio Bagarinao; Kazuya Kawabata; Akihiro Ueda; Mizuki Ito; Junichi Hata; Shinsuke Ishigaki; Junichiro Yoshimoto; Hiroshi Toyama; Takahiko Tokuda; Akihiko Takashima; Hirohisa Watanabe
Frontiers in Aging Neuroscience, 20 Aug. 2025, URL

Correcting tau isoform ratios with a long-acting antisense oligonucleotide alleviates 4R-tauopathy phenotypes
Kuniyuki Iwata-Endo, Kentaro Sahashi, Kaori Kawai, Yusuke Fujioka, Yohei Okada, Eri Watanabe, Nobuyuki Iwade, Minaka Ishibashi, Moniruzzaman Mohammad, Asraa Faris Aldoghachi, Dilina Tuerde, Tsuyoshi Fujiwara, Shinobu Hirai, Haruo Okado, Masahisa Katsuno, Hirohisa Watanabe, Kayoko Kanamitsu, Masahiro Neya, Shinsuke Ishigaki, Gen Sobue
Molecular Therapy Nucleic Acids, Jun. 2025, Refereed, Corresponding

アルツハイマー病の最初期病変を捉える3Dバーチャルリアリティナビタスクの開発
島 さゆり; 大嶽 れい子; 高島 明彦; 徳田 隆彦; 石垣 診祐; 畑 純一; エピファニオ・バガリナオ; 笠井 淳史; 水谷 泰彰; 植田 晃広; 伊藤 瑞規; 渡辺 宏久
臨床神経学, Oct. 2024

アルツハイマー病の最初期病変を捉える3D VRナビタスクの開発
島 さゆり; 大嶽 れい子; 高島 明彦; 徳田 隆彦; 石垣 診祐; 畑 純一; エピファニオ・バガリナオ; 水谷 泰彰; 植田 晃広; 伊藤 瑞規; 渡辺 宏久
Dementia Japan, Oct. 2024

APPトランスジェニックカニクイザルの脳脊髄液バイオマーカーの変化
柳沢 大治郎; 守村 敏史; 西村 正樹; 辻 敬一; 辻 篤司; 遠山 育夫; 依馬 正次; 石垣 診祐
Dementia Japan, Oct. 2024

A novel monoclonal antibody generated by immunization with granular tau oligomers binds to tau aggregates at 423-430 amino acid sequence
Yoshiyuki Soeda; Emi Hayashi; Naoko Nakatani; Shinsuke Ishigaki; Yuta Takaichi; Taro Tachibana; Yuichi Riku; James K. Chambers; Riki Koike; Moniruzzaman Mohammad; Akihiko Takashima
Scientific Reports, 26 Jul. 2024, Refereed, URL

Early detection of Alzheimer’s disease pathophysiology using 3D virtual reality navigation: a correlational study with genetic and plasma biomarkers
Sayuri Shima; Reiko Ohdake; Yasuaki Mizutani; Harutsugu Tatebe; Riki Koike; Atsushi Kasai; Epifanio Bagarinao; Akihiro Ueda; Mizuki Ito; Junichi Hata; Shinsuke Ishigaki; Takahiko Tokuda; Akihiko Takashima; Hirohisa Watanabe
02 May 2024, URL

Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes
Asraa Faris Aldoghachi; Daijiro Yanagisawa; Aslina Pahrudin Arrozi; Zulzikry Hafiz Abu Bakar; Hiroyasu Taguchi; Shinsuke Ishigaki; Katsutaro Morino; Ikuo Tooyama
Biochemical and Biophysical Research Communications, 29 Jan. 2024, Refereed

Stress-impaired reward pathway promotes distinct feeding behavior patterns.
Yusuke Fujioka; Kaori Kawai; Kuniyuki Endo; Minaka Ishibashi; Nobuyuki Iwade; Dilina Tuerde; Kozo Kaibuchi; Takayuki Yamashita; Akihiro Yamanaka; Masahisa Katsuno; Hirohisa Watanabe; Gen Sobue; Shinsuke Ishigaki
Frontiers in neuroscience, 2024, Refereed, Corresponding

Path integration deficits are associated with phosphorylated tau accumulation in the entorhinal cortex.
Riki Koike; Yoshiyuki Soeda; Atsushi Kasai; Yusuke Fujioka; Shinsuke Ishigaki; Akihiro Yamanaka; Yuta Takaichi; James K Chambers; Kazuyuki Uchida; Hirohisa Watanabe; Akihiko Takashima
Brain communications, 2024, Refereed

Path integration deficits predict phosphorylated tau accumulation in the entorhinal cortex: Assessment of Braak stage I,II using 3D Virtual reality goggles
Akihiko Takashima; Riki Koike; Yoshiyuki Soeda; Yusuke Fujioka; Shinsuke Ishigaki; Hirohisa Watanabe
Alzheimer's & Dementia, 25 Dec. 2023

ALS/FTLDおよび4Rタウオパチーの新規治療標的探索
石垣 診祐
上原記念生命科学財団研究報告集, Dec. 2023

嗅内野のタウ蓄積が引き起こす空間ナビゲーション異常の可能性
小池 力; 添田 義行; 藤岡 祐介; 石垣 診祐; 渡辺 宏久; 畑 純一; 高島 明彦
Dementia Japan, Oct. 2023

TDP-43を標的とした核酸医薬はALS/FTDマウスに対して持続的な治療効果を発揮する
武内 敏秀; 前田 和宏; 丁 欣; 大江 由佳子; 武田 明子; 井上 真奈; 長野 清一; 藤原 健志; 松田 誠司; 石垣 診祐; 佐橋 健太郎; 皆川 栄子; 望月 秀樹; 閨 正博; 祖父江 元; 永井 義隆
Dementia Japan, Oct. 2023

APPトランスジェニックカニクイザルの開発 脳脊髄液バイオマーカー
柳沢 大治郎; 守村 敏史; 西村 正樹; 遠山 育夫; 依馬 正次; 石垣 診祐
Dementia Japan, Oct. 2023

アルツハイマー病の最初期病変を捉える3D VRナビタスクと血漿GFAPの関係
島 さゆり; 大嶽 れい子; 高島 明彦; 徳田 隆彦; 石垣 診祐; 畑 純一; エピファニオ・バガリナオ; 笠井 淳史; 村手 健一郎; 水谷 泰彰; 植田 晃広; 伊藤 瑞規; 渡辺 宏久
臨床神経学, Sep. 2023

Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.
Toshihide Takeuchi; Kazuhiro Maeta; Xin Ding; Yukako Oe; Akiko Takeda; Mana Inoue; Seiichi Nagano; Tsuyoshi Fujihara; Seiji Matsuda; Shinsuke Ishigaki; Kentaro Sahashi; Eiko N Minakawa; Hideki Mochizuki; Masahiro Neya; Gen Sobue; Yoshitaka Nagai
Molecular therapy. Nucleic acids, 14 Mar. 2023, Refereed

【ALS-どこまでわかり,どこまで治るか】原因と発症機序 FUS
石垣 診祐
Clinical Neuroscience, Mar. 2023

TDP-43 Proteinopathy and Tauopathy: Do They Have Pathomechanistic Links?
Yuichi Riku; Mari Yoshida; Yasushi Iwasaki; Gen Sobue; Masahisa Katsuno; Shinsuke Ishigaki
International journal of molecular sciences, 12 Dec. 2022, Refereed, Last

タウは食行動パターンに関与する報酬系を制御している(Tau regulates reward-system which is responsible for eating behavior pattern)
藤岡 祐介; 河合 香里; 勝野 雅央; 高島 明彦; 祖父江 元; 石垣 診祐
老年精神医学雑誌, Nov. 2022

コモンマーモセットを用いたFTLDのバイオマーカー開発(Biomarker development for FTLD using common marmosets)
石垣 診祐; 金 侑璃; 遠藤 邦幸; 藤岡 祐介; 力武 聖月; 畑 純一; 中村 克樹
老年精神医学雑誌, Nov. 2022

ストレス負荷による食行動パターンの変化と報酬系異常に関する解析
河合 香里; 藤岡 祐介; 勝野 雅央; 石垣 診祐; 祖父江 元
日本生化学会大会プログラム・講演要旨集, Nov. 2022

The SYNGAP1 3'UTR variant in ALS patients causes aberrant SYNGAP1 splicing and dendritic spine loss by recruiting HNRNPK.
Satoshi Yokoi; Takuji Ito; Kentaro Sahashi; Masahiro Nakatochi; Ryoichi Nakamura; Genki Tohnai; Yusuke Fujioka; Shinsuke Ishigaki; Tsuyoshi Udagawa; Yuishin Izumi; Mitsuya Morita; Osamu Kano; Masaya Oda; Takefumi Sone; Hideyuki Okano; Naoki Atsuta; Masahisa Katsuno; Yohei Okada; Gen Sobue
The Journal of neuroscience : the official journal of the Society for Neuroscience, 13 Oct. 2022, Refereed

アルツハイマー病の最初期病変を捉える3D VRナビゲーション課題の開発
渡辺 宏久; 大嶽 れい子; 高島 明彦; 徳田 隆彦; 石垣 診祐; 畑 純一; ばがりなお・えぴふぁにお; 村手 健一郎; 水谷 泰彰; 島 さゆり; 植田 晃広; 伊藤 瑞規
臨床神経学, Oct. 2022

【革新脳と関連プロジェクトから見えてきた新しい脳科学】ヒト疾患研究 b)神経変性疾患 孤発性ALSの神経生物学
陸 雄一; 石垣 診祐; 祖父江 元
生体の科学, Oct. 2022

タウによる食行動パターンに関与する報酬系の制御(Tau regulates reward-system which is responsible for eating behavior pattern)
藤岡 祐介; 河合 香里; 勝野 雅央; 高島 明彦; 祖父江 元; 石垣 診祐
Dementia Japan, Oct. 2022

コモンマーモセットを用いたFTLDのバイオマーカーの開発(Biomarker development of FTLD using common marmosets)
石垣 診祐; 金 侑璃; 遠藤 邦幸; 藤岡 祐介; 力武 聖月; 畑 純一; 中村 克樹
Dementia Japan, Oct. 2022

アルツハイマー病の最初期病変を捉える3D VRナビゲーション課題の開発
渡辺 宏久; 大嶽 れい子; 高島 明彦; 徳田 隆彦; 石垣 診祐; 畑 純一; ばがりなお・えぴふぁにお; 村手 健一郎; 水谷 泰彰; 島 さゆり; 植田 晃広; 伊藤 瑞規
臨床神経学, Oct. 2022

Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology.
Koyo Tsujikawa; Kohei Hamanaka; Yuichi Riku; Yuki Hattori; Norikazu Hara; Yohei Iguchi; Shinsuke Ishigaki; Atsushi Hashizume; Satoko Miyatake; Satomi Mitsuhashi; Yu Miyazaki; Mayumi Kataoka; Li Jiayi; Keizo Yasui; Satoshi Kuru; Haruki Koike; Kenta Kobayashi; Naruhiko Sahara; Norio Ozaki; Mari Yoshida; Akiyoshi Kakita; Yuko Saito; Yasushi Iwasaki; Akinori Miyashita; Takeshi Iwatsubo; Takeshi Ikeuchi; Takaki Miyata; Gen Sobue; Naomichi Matsumoto; Kentaro Sahashi; Masahisa Katsuno
Science advances, 27 May 2022, Refereed

Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration.
Yuichi Riku; Yasushi Iwasaki; Shinsuke Ishigaki; Akio Akagi; Masato Hasegawa; Kenya Nishioka; Yuanzhe Li; Miho Riku; Takeshi Ikeuchi; Yusuke Fujioka; Hiroaki Miyahara; Jun Sone; Nobutaka Hattori; Mari Yoshida; Masahisa Katsuno; Gen Sobue
Brain : a journal of neurology, 11 Mar. 2022, Refereed

分子生物学的側面から考えるFTLDの新たな疾患概念
石垣 診祐
核医学, Oct. 2021

FTLD疾患スペクトラムに共通する病態としてのFUS機能不全
石垣 診祐
BRAIN and NERVE: 神経研究の進歩, Sep. 2021, URL

前頭側頭葉変性症の診断と治療Up to date FUSの機能的側面から考えるFTLDの新たな疾患概念
石垣 診祐
老年精神医学雑誌, Sep. 2021

Pathway from TDP-43-Related Pathology to Neuronal Dysfunction in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration.
Yuichi Riku; Danielle Seilhean; Charles Duyckaerts; Susana Boluda; Yohei Iguchi; Shinsuke Ishigaki; Yasushi Iwasaki; Mari Yoshida; Gen Sobue; Masahisa Katsuno
International journal of molecular sciences, 08 Apr. 2021, Refereed

タウオパチーにおけるRNA結合タンパク質の機能不全と治療薬開発の展望
石垣 診祐; 祖父江 元
臨床神経学, Nov. 2020

ALSコホート由来のSynGAP 3'-UTRの変異はFUS-SynGAP mRNAの調節とスパインの形成に異常を引き起こす(SynGAP 3'UTR mutation from ALS cohort causes aberrant FUS-SynGAP mRNA regulation and spine formation)
Yokoi Satoshi; Ito Takuji; Sahashi Kentaro; Nakamura Ryoichi; Ishigaki Shinsuke; Atsuta Naoki; Katsuno Masahisa; Okada Yohei; Sobue Gen
臨床神経学, Nov. 2020

広範囲のFTLDスペクトラム疾患で認められる異常なFUS-SFPQ相互作用(Aberrant FUS-SFPQ interaction in a wide-range of FTLD spectrum diseases)
石垣 診祐; 陸 雄一; 吉田 眞理; 祖父江 元
Dementia Japan, Oct. 2020

Aberrant interaction between FUS and SFPQ in neurons in a wide range of FTLD spectrum diseases.
Shinsuke Ishigaki; Yuichi Riku; Yusuke Fujioka; Kuniyuki Endo; Nobuyuki Iwade; Kaori Kawai; Minaka Ishibashi; Satoshi Yokoi; Masahisa Katsuno; Hirohisa Watanabe; Keiko Mori; Akio Akagi; Osamu Yokota; Seishi Terada; Ito Kawakami; Naoki Suzuki; Hitoshi Warita; Masashi Aoki; Mari Yoshida; Gen Sobue
Brain : a journal of neurology, 01 Aug. 2020, Refereed

Characteristic Features of FUS Inclusions in Spinal Motor Neurons of Sporadic Amyotrophic Lateral Sclerosis.
Kensuke Ikenaka; Shinsuke Ishigaki; Yohei Iguchi; Kaori Kawai; Yusuke Fujioka; Satoshi Yokoi; Rehab F Abdelhamid; Seiichi Nagano; Hideki Mochizuki; Masahisa Katsuno; Gen Sobue
Journal of neuropathology and experimental neurology, 01 Apr. 2020, Refereed, Not invited

FUS喪失はhiPSC由来運動神経細胞のスパイン異常とSynGAP欠失を誘発する(FUS depletion induces spine abnormality and SynGAP depletion in hiPSC-derived motor neuron)
Yokoi Satoshi; Ito Takuji; Sahashi Kentaro; Ishigaki Shinsuke; Katsuno Masahisa; Okada Yohei; Sobue Gen
臨床神経学, Nov. 2019

TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets.
Kunihiko Araki; Amane Araki; Daiyu Honda; Takako Izumoto; Atsushi Hashizume; Yasuhiro Hijikata; Shinichiro Yamada; Yohei Iguchi; Akitoshi Hara; Kazuhiro Ikumi; Kaori Kawai; Shinsuke Ishigaki; Yoko Nakamichi; Shin Tsunekawa; Yusuke Seino; Akiko Yamamoto; Yasunori Takayama; Shihomi Hidaka; Makoto Tominaga; Mica Ohara-Imaizumi; Atsushi Suzuki; Hiroshi Ishiguro; Atsushi Enomoto; Mari Yoshida; Hiroshi Arima; Shin-Ichi Muramatsu; Gen Sobue; Masahisa Katsuno
The Journal of clinical investigation, 29 Jul. 2019, Refereed, Not invited

Tau isoform expression and phosphorylation in marmoset brains.
Govinda Sharma; Anni Huo; Taeko Kimura; Seiji Shiozawa; Reona Kobayashi; Naruhiko Sahara; Minaka Ishibashi; Shinsuke Ishigaki; Taro Saito; Kanae Ando; Shigeo Murayama; Masato Hasegawa; Gen Sobue; Hideyuki Okano; Shin-Ichi Hisanaga
The Journal of biological chemistry, 26 Jul. 2019, Refereed, Not invited

TAU in marmoset brains, its isoform expression and phosphorylation
Hisanaga S; Sharma G; Huo A; Kimura T; Shiozawa S; Kobayashi R; Sahara N; Ishibashi M; Ishigaki S; Saito T; Ando K; Murayama S; Hasegawa M; Sobue G; Okano H
JOURNAL OF NEUROCHEMISTRY, Jul. 2019

Tau Accumulation and Network Breakdown in Alzheimer's Disease.
Hirohisa Watanabe; Epifanio Bagarinao; Takamasa Yokoi; Hiroshi Yamaguchi; Shinsuke Ishigaki; Michihito Mausuda; Masahisa Katsuno; Gen Sobue
Advances in experimental medicine and biology, 2019, Refereed, Not invited

Silencing of FUS in the common marmoset (Callithrix jacchus) brain via stereotaxic injection of an adeno-associated virus encoding shRNA.
Kuniyuki Endo; Shinsuke Ishigaki; Yoshito Masamizu; Yusuke Fujioka; Akiya Watakabe; Tetsuo Yamamori; Nobuhiko Hatanaka; Atsushi Nambu; Haruo Okado; Masahisa Katsuno; Hirohisa Watanabe; Masanori Matsuzaki; Gen Sobue
Neuroscience research, May 2018, Refereed, Not invited, Corresponding

Importance of Functional Loss of FUS in FTLD/ALS.
Shinsuke Ishigaki; Gen Sobue
Frontiers in molecular biosciences, 2018, Refereed, Not invited

Pathogenesis of Frontotemporal Lobar Degeneration: Insights From Loss of Function Theory and Early Involvement of the Caudate Nucleus.
Gen Sobue; Shinsuke Ishigaki; Hirohisa Watanabe
Frontiers in neuroscience, 2018, Refereed, Not invited

Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer's Disease: A PET (THK5351, PiB) and Resting fMRI Study.
Takamasa Yokoi; Hirohisa Watanabe; Hiroshi Yamaguchi; Epifanio Bagarinao; Michihito Masuda; Kazunori Imai; Aya Ogura; Reiko Ohdake; Kazuya Kawabata; Kazuhiro Hara; Yuichi Riku; Shinsuke Ishigaki; Masahisa Katsuno; Shinichi Miyao; Katsuhiko Kato; Shinji Naganawa; Ryuichi Harada; Nobuyuki Okamura; Kazuhiko Yanai; Mari Yoshida; Gen Sobue
Frontiers in aging neuroscience, 2018, Refereed, Not invited

Pathologic Involvement of Glutamatergic Striatal Inputs From the Cortices in TAR DNA-Binding Protein 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
Yuichi Riku; Hirohisa Watanabe; Mari Yoshida; Maya Mimuro; Yasushi Iwasaki; Michihito Masuda; Shinsuke Ishigaki; Masahisa Katsuno; Gen Sobue
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, Sep. 2017, Refereed, Not invited

3 ' UTR Length-Dependent Control of SynGAP Isoform alpha 2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function
Satoshi Yokoi; Tsuyoshi Udagawa; Yusuke Fujioka; Daiyu Honda; Haruo Okado; Hirohisa Watanabe; Masahisa Katsuno; Shinsuke Ishigaki; Gen Sobue
CELL REPORTS, Sep. 2017, Refereed, Not invited, Corresponding

Altered GluA1 (Gria1) Function and Accumbal Synaptic Plasticity in the ClockΔ19 Model of Bipolar Mania.
Parekh PK; Becker-Krail D; Sundaravelu P; Ishigaki S; Okado H; Sobue G; Huang Y; McClung CA
Biological psychiatry, Jun. 2017, Refereed, Not invited

Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes
Shinsuke Ishigaki; Yusuke Fujioka; Yohei Okada; Yuichi Riku; Tsuyoshi Udagawa; Daiyu Honda; Satoshi Yokoi; Kuniyuki Endo; Kensuke Ikenaka; Shinnosuke Takagi; Yohei Iguchi; Naruhiko Sahara; Akihiko Takashima; Hideyuki Okano; Mari Yoshida; Hitoshi Warita; Masashi Aoki; Hirohisa Watanabe; Haruo Okado; Masahisa Katsuno; Gen Sobue
CELL REPORTS, Jan. 2017, Refereed, Not invited

Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis.
Takeuchi H; Kobayashi Y; Ishigaki S; Doyu M; Sobue G
The Journal of biological chemistry, Oct. 2016

Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum
Michihito Masuda; Joe Senda; Hirohisa Watanabe; Bagarinao Epifanio; Yasuhiro Tanaka; Kazunori Imai; Yuchi Riku; Yuanzhe Li; Ryoichi Nakamura; Mizuki Ito; Shinsuke Ishigaki; Naoki Atsuta; Haruki Koike; Masahisa Katsuno; Nobutaka Hattori; Shinji Naganawa; Gen Sobue
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION, Oct. 2016, Refereed, Not invited

A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN
Hazuki Watanabe; Naoki Atsuta; Akihiro Hirakawa; Ryoichi Nakamura; Masahiro Nakatochi; Shinsuke Ishigaki; Aritoshi Iida; Shiro Ikegawa; Michiaki Kubo; Daichi Yokoi; Hirohisa Watanabe; Mizuki Ito; Masahisa Katsuno; Yuishin Izumi; Mitsuya Morita; Kazuaki Kanai; Akira Taniguchi; Ikuko Aiba; Koji Abe; Koichi Mizoguchi; Masaya Oda; Osamu Kano; Koichi Okamoto; Satoshi Kuwabara; Kazuko Hasegawa; Takashi Imai; Akihiro Kawata; Masashi Aoki; Shoji Tsuji; Kenji Nakashima; Ryuji Kaji; Gen Sobue
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Aug. 2016, Refereed, Not invited

Marked Involvement of the Striatal Efferent System in TAR DNA-Binding Protein 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
Yuichi Riku; Hirohisa Watanabe; Mari Yoshida; Maya Mimuro; Yasushi Iwasaki; Michihito Masuda; Shinsuke Ishigaki; Masahisa Katsuno; Gen Sobue
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, Aug. 2016, Refereed, Not invited

R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5
Hiroaki Nakashima; Bisei Ohkawara; Shinsuke Ishigaki; Takayasu Fukudome; Kenyu Ito; Mikito Tsushima; Hiroyuki Konishi; Tatsuya Okuno; Toshiro Yoshimura; Mikako Ito; Akio Masuda; Gen Sobue; Hiroshi Kiyama; Naoki Ishiguro; Kinji Ohno
SCIENTIFIC REPORTS, Jun. 2016, Refereed, Not invited

Gene Expression Profile of Inflammatory Myopathy with Malignancy is Similar to that of Dermatomyositis rather than Polymyositis
Tomoko Noda; Masahiro Iijima; Seiya Noda; Shinya Maeshima; Hirotaka Nakanishi; Seigo Kimura; Haruki Koike; Shinsuke Ishigaki; Yohei Iguchi; Masahisa Katsuno; Gen Sobue
INTERNAL MEDICINE, 2016, Refereed, Not invited

ALSにおける尾状核頭部連結性の関与(Involvement of caudate nucleus head connectivities in ALS)
渡辺 宏久; 桝田 道人; 千田 譲; Bagarinao Epifanio; 田中 康博; 陸 雄一; 中村 良一; 渡辺 はづき; 伊藤 瑞規; 石垣 診祐; 熱田 直樹; 勝野 雅央; 長縄 慎二; 祖父江 元
臨床神経学, Dec. 2015

Microglial Keratan Sulfate Epitope Elicits in Central Nervous Tissues of Transgenic Model Mice and Patients with Amyotrophic Lateral Sclerosis
Tahmina Foyez; Yoshiko Takeda-Uchimura; Shinsuke Ishigaki; Narentuya; Zui Zhang; Gen Sobue; Kenji Kadomatsu; Kenji Uchimura
AMERICAN JOURNAL OF PATHOLOGY, Nov. 2015, Refereed, Not invited

A highly sensitive assay of IRE1 activity using the small luciferase NanoLuc: Evaluation of ALS-related genetic and pathological factors
Takahiro Hikiji; Junpei Norisada; Yoko Hirata; Kensuke Okuda; Hideko Nagasawa; Shinsuke Ishigaki; Gen Sobue; Kazutoshi Kiuchi; Kentaro Oh-hashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2015, Refereed, Not invited

Transcriptional and post-transcriptional regulation of transmembrane protein 132A
Kentaro Oh-hashi; Azumi Sone; Takahiro Hikiji; Yoko Hirata; Michela Vitiello; Monica Fedele; Shinsuke Ishigaki; Gen Sobue; Kazutoshi Kiuchi
MOLECULAR AND CELLULAR BIOCHEMISTRY, Jul. 2015, Refereed, Not invited

FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization
Tsuyoshi Udagawa; Yusuke Fujioka; Motoki Tanaka; Daiyu Honda; Satoshi Yokoi; Yuichi Riku; Daisuke Ibi; Taku Nagai; Kiyofumi Yamada; Hirohisa Watanabe; Masahisa Katsuno; Toshifumi Inada; Kinji Ohno; Masahiro Sokabe; Haruo Okado; Shinsuke Ishigaki; Gen Sobue
NATURE COMMUNICATIONS, May 2015, Refereed, Not invited, Corresponding

Position-specific binding of FUS to nascent RNA regulates mRNA length
Akio Masuda; Jun-ichi Takeda; Tatsuya Okuno; Takaaki Okamoto; Bisei Ohkawara; Mikako Ito; Shinsuke Ishigaki; Gen Sobue; Kinji Ohno
GENES & DEVELOPMENT, May 2015, Refereed, Not invited

筋萎縮性側索硬化症と前頭側頭型認知症はMRIにて共通の皮質・皮質下病変を有する
渡辺 宏久; 千田 譲; 桝田 道人; 陸 雄一; 勝野 雅央; 石垣 診祐; 熱田 直樹; 伊藤 瑞規; 中村 亮一; 渡辺 はづき; 原 一洋; 坪井 崇; 米山 典孝; 長縄 慎二; 祖父江 元
臨床神経学, Dec. 2014

Lower Motor Neuron Involvement in TAR DNA-Binding Protein of 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
Yuichi Riku; Hirohisa Watanabe; Mari Yoshida; Shinsui Tatsumi; Maya Mimuro; Yasushi Iwasaki; Masahisa Katsuno; Yohei Iguchi; Michihito Masuda; Jo Senda; Shinsuke Ishigaki; Tsuyoshi Udagawa; Gen Sobue
JAMA NEUROLOGY, Feb. 2014, Refereed, Not invited

Corrigendum to "The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons" [FEBS Open Bio 4 (2014) 1-10]
Daiyu Honda; Shinsuke Ishigaki; Yohei Iguchi; Yusuke Fujioka; Tsuyoshi Udagawa; Akio Masuda; Kinji Ohno; Masahisa Katsuno; Gen Sobue
FEBS Open Bio, 2014, Refereed, Not invited

The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons
Daiyu Honda; Shinsuke Ishigaki; Yohei Iguchi; Yusuke Fujioka; Tsuyoshi Udagawa; Akio Masuda; Kinji Ohno; Masahisa Katsuno; Gen Sobue
FEBS OPEN BIO, 2014, Refereed, Not invited, Corresponding

Amyotrophic lateral sclerosis: an update on recent genetic insights
Yohei Iguchi; Masahisa Katsuno; Kensuke Ikenaka; Shinsuke Ishigaki; Gen Sobue
JOURNAL OF NEUROLOGY, Nov. 2013, Refereed, Not invited

FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress
Reddy Ranjith K. Sama; Catherine L. Ward; Laura J. Kaushansky; Nathan Lemay; Shinsuke Ishigaki; Fumihiko Urano; Daryl A. Bosco
Journal of Cellular Physiology, Nov. 2013, Refereed, Not invited

Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells
Kohsuke Kanekura; Shinsuke Ishigaki; Philip I. Merksamer; Feroz R. Papa; Fumihiko Urano
LABORATORY INVESTIGATION, Nov. 2013, Refereed, Not invited, Lead

The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons
Fumika Koyano; Kei Okatsu; Shinsuke Ishigaki; Yusuke Fujioka; Mayumi Kimura; Gen Sobue; Keiji Tanaka; Noriyuki Matsuda
Genes to Cells, Aug. 2013, Refereed, Not invited

RNP2 of RNA Recognition Motif 1 Plays a Central Role in the Aberrant Modification of TDP-43
Shinnosuke Takagi; Yohei Iguchi; Masahisa Katsuno; Shinsuke Ishigaki; Kensuke Ikenaka; Yusuke Fujioka; Daiyu Honda; Jun-ichi Niwa; Fumiaki Tanaka; Hirohisa Watanabe; Hiroaki Adachi; Gen Sobue
PLOS ONE, Jun. 2013, Refereed, Not invited

Loss of TDP-43 causes age-dependent progressive motor neuron degeneration
Yohei Iguchi; Masahisa Katsuno; Jun-ichi Niwa; Shinnosuke Takagi; Shinsuke Ishigaki; Kensuke Ikenaka; Kaori Kawai; Hirohisa Watanabe; Koji Yamanaka; Ryosuke Takahashi; Hidemi Misawa; Shoichi Sasaki; Fumiaki Tanaka; Gen Sobue
BRAIN, May 2013, Refereed, Not invited

Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration
Naohide Kondo; Masahisa Katsuno; Hiroaki Adachi; Makoto Minamiyama; Hideki Doi; Shinjiro Matsumoto; Yu Miyazaki; Madoka Iida; Genki Tohnai; Hideaki Nakatsuji; Shinsuke Ishigaki; Yusuke Fujioka; Hirohisa Watanabe; Fumiaki Tanaka; Akira Nakai; Gen Sobue
NATURE COMMUNICATIONS, Jan. 2013, Refereed, Not invited

FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD.
Yusuke Fujioka; Shinsuke Ishigaki; Akio Masuda; Yohei Iguchi; Tsuyoshi Udagawa; Hirohisa Watanabe; Masahisa Katsuno; Kinji Ohno; Gen Sobue
Scientific reports, 2013, Refereed, Not invited, Corresponding

Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract
Makoto Minamiyama; Masahisa Katsuno; Hiroaki Adachi; Hideki Doi; Naohide Kondo; Madoka Iida; Shinsuke Ishigaki; Yusuke Fujioka; Shinjiro Matsumoto; Yu Miyazaki; Fumiaki Tanaka; Hiroki Kurihara; Gen Sobue
NATURE MEDICINE, Oct. 2012, Refereed, Not invited

c-Abl Inhibition Delays Motor Neuron Degeneration in the G93A Mouse, an Animal Model of Amyotrophic Lateral Sclerosis
Ryu Katsumata; Shinsuke Ishigaki; Masahisa Katsuno; Kaori Kawai; Jun Sone; Zhe Huang; Hiroaki Adachi; Fumiaki Tanaka; Fumihiko Urano; Gen Sobue
PLOS ONE, Sep. 2012, Refereed, Not invited

Thioredoxin-Interacting Protein Mediates ER Stress-Induced beta Cell Death through Initiation of the Inflammasome
Christine M. Oslowski; Takashi Hara; Bryan O'Sullivan-Murphy; Kohsuke Kanekura; Simin Lu; Mariko Hara; Shinsuke Ishigaki; Lihua J. Zhu; Emiko Hayashi; Simon T. Hui; Dale Greiner; Randal J. Kaufman; Rita Bortell; Fumihiko Urano
CELL METABOLISM, Aug. 2012, Refereed, Not invited

Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions
Shinsuke Ishigaki; Akio Masuda; Yusuke Fujioka; Yohei Iguchi; Masahisa Katsuno; Akihide Shibata; Fumihiko Urano; Gen Sobue; Kinji Ohno
SCIENTIFIC REPORTS, Jul. 2012, Refereed, Not invited, Lead

Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies
Yohei Iguchi; Masahisa Katsuno; Shinnosuke Takagi; Shinsuke Ishigaki; Jun-ichi Niwa; Masato Hasegawa; Fumiaki Tanaka; Gen Sobue
NEUROBIOLOGY OF DISEASE, Mar. 2012, Refereed, Not invited

Disruption of Axonal Transport in Motor Neuron Diseases
Kensuke Ikenaka; Masahisa Katsuno; Kaori Kawai; Shinsuke Ishigaki; Fumiaki Tanaka; Gen Sobue
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Jan. 2012, Refereed, Not invited

AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1
S. Ishigaki; S. G. Fonseca; C. M. Oslowski; A. Jurczyk; J. R. Shearstone; L. J. Zhu; M. A. Permutt; D. L. Greiner; R. Bortell; F. Urano
CELL DEATH AND DIFFERENTIATION, May 2010, Refereed, Not invited

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells
Sonya G. Fonseca; Shinsuke Ishigaki; Christine M. Oslowski; Simin Lu; Kathryn L. Lipson; Rajarshi Ghosh; Emiko Hayashi; Hisamitsu Ishihara; Yoshitomo Oka; M. Alan Permutt; Fumihiko Urano
JOURNAL OF CLINICAL INVESTIGATION, Mar. 2010, Refereed, Not invited

Dorfin Ameliorates Phenotypes in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
Jun Sone; Jun-ichi Niwa; Kaori Kawai; Shinsuke Ishigaki; Shin-ichi Yamada; Hiroaki Adachi; Masahisa Katsuno; Fumiaki Tanaka; Manabu Doyu; Gen Sobue
JOURNAL OF NEUROSCIENCE RESEARCH, Jan. 2010, Refereed, Not invited

Valproate, a Mood Stabilizer, Induces WFS1 Expression and Modulates Its Interaction with ER Stress Protein GRP94
Chihiro Kakiuchi; Shinsuke Ishigaki; Christine M. Oslowski; Sonya G. Fonseca; Tadafumi Kato; Fumihiko Urano
PLOS ONE, Jan. 2009, Refereed, Not invited

Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1
Jun-ichi Niwa; Shin-ichi Yamada; Shinsuke Ishigaki; Jun Sone; Miho Takahashi; Masahisa Katsuno; Fumiaki Tanaka; Manabu Doyu; Gen Sobue
JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2007, Refereed, Not invited

Gene expressions specifically detected in motor neurons (Dynactin 1, early growth response 3, acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to Pathologic markers in sporadic amyotrophic lateral sclerosis
Yue-Mei Jiang; Masahiko Yamamoto; Fumiaki Tanaka; Shinsuke Ishigaki; Masahisa Katsuno; Hiroaki Adachi; Jun-ichi Niwa; Manabu Doyu; Marl Yoshida; Yoshio Hashizume; Gen Sobue
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, Jul. 2007, Refereed, Not invited

Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity
Shinsuke Ishigaki; Jun-ichi Niwa; Shin-ichi Yamada; Miho Takahashi; Takashi Ito; Jun Sone; Manabu Doyu; Fumihiko Urano; Gen Sobue
NEUROBIOLOGY OF DISEASE, Feb. 2007, Refereed, Not invited, Lead

Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1
Kathryn L. Lipson; Sonya G. Fonseca; Shinsuke Ishigaki; Linh X. Nguyen; Elizabeth Foss; Rita Bortell; Aldo A. Rossini; Fumihiko Urano
CELL METABOLISM, Sep. 2006, Refereed, Not invited

Archaeal proteasomes effectively degrade aggregation-prone proteins and reduce cellular toxicities in mammalian cells
Shin-ichi Yamada; Jun-ichi Niwa; Shinsuke Ishigaki; Miho Takahashi; Takashi Ito; Jun Sone; Manabu Doyu; Gen Sobue
JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2006, Refereed, Not invited

Gene expression profiling toward understanding of ALS pathogenesis
Fumiaki Tanaka; Jun-ichi Niwa; Shinsuke Ishigaki; Masahisa Katsuno; Masahiro Waza; Masahiko Yamamoto; Manabu Doyu; Gen Sobue
INTEGRATED MOLECULAR MEDICINE FOR NEURONAL AND NEOPLASTIC DISORDERS, 2006, Refereed, Not invited

Motor neuron disease up-to-date
Masahiko Yamamoto; Shinsuke Ishigaki; Masahisa Katsuno; Gen Sobue
Brain and Nerve, Apr. 2005, Refereed, Not invited

Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis
YM Jiang; M Yamamoto; Y Kobayashi; T Yoshihara; YD Liang; S Terao; H Takeuchi; S Ishigaki; M Katsuno; H Adachi; J Niwa; F Tanaka; M Doyu; M Yoshida; Y Hashizume; G Sobue
ANNALS OF NEUROLOGY, Feb. 2005, Refereed, Not invited

Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders
S Ishigaki; N Hishikawa; J Niwa; S Iemura; T Natsume; S Hori; A Kakizuka; K Tanaka; G Sobue
JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2004, Refereed, Not invited, Lead

Dorfin prevents cell death by reducing mitochondrial localizing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis
H Takeuchi; J Niwa; N Hishikawa; S Ishigaki; F Tanaka; M Doyu; G Sobue
JOURNAL OF NEUROCHEMISTRY, Apr. 2004, Refereed, Not invited

Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1
T Ito; J Niwa; N Hishikawa; S Ishigaki; M Doyu; G Sobue
JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2003, Refereed, Not invited

Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis
N Hishikawa; J Niwa; M Doyu; T Ito; S Ishigaki; Y Hashizume; G Sobue
AMERICAN JOURNAL OF PATHOLOGY, Aug. 2003, Refereed, Not invited

Caspase-1 and-3 mRNAs are differentially upregulated in motor neurons and glial cells in mutant SOD1 transgenic mouse spinal cord: A study using laser microdissection and real-time RT-PCR
Y Ando; YD Liang; S Ishigaki; JI Niwa; YM Jiang; Y Kobayashi; M Yamamoto; M Doyu; G Sobue
NEUROCHEMICAL RESEARCH, Jun. 2003, Refereed, Not invited

Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis
H Takeuchi; Y Kobayashi; S Ishigaki; M Doyu; G Sobue
JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2002, Refereed, Not invited

Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords - screening by molecular indexing and subsequent cDNA microarray analysis
S Ishigaki; J Niwa; Y Ando; T Yoshihara; K Sawada; M Doyu; M Yamamoto; K Kato; Y Yotsumoto; G Sobue
FEBS LETTERS, Nov. 2002, Refereed, Not invited, Lead

Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity
J Niwa; S Ishigaki; N Hishikawa; M Yamamoto; M Doyu; S Murata; K Tanaka; N Taniguchi; G Sobue
JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2002, Refereed, Not invited

X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration
S Ishigaki; Y Liang; M Yamamoto; J Niwa; Y Ando; T Yoshihara; H Takeuchi; M Doyu; G Sobue
JOURNAL OF NEUROCHEMISTRY, Aug. 2002, Refereed, Not invited, Lead

Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis
T Yoshihara; S Ishigaki; M Yamamoto; Y Liang; J Niwa; H Takeuchi; M Doyu; G Sobue
JOURNAL OF NEUROCHEMISTRY, Jan. 2002, Refereed, Not invited

Cloning of novel genes from the human spinal cord by molecular profiling
J Niwa; S Ishigaki; M Doyu; G Sobue
CATECHOLAMINE RESEARCH: FROM MOLECULAR INSIGHTS TO CLINICAL MEDICINE, 2002, Refereed, Not invited

A novel centrosomal RING-finger protein, Dorfin, mediates ubiquitin ligase activity
J Niwa; S Ishigaki; M Doyu; T Suzuki; K Tanaka; G Sobue
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2001, Refereed, Not invited

Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells
S Ishigaki; J Niwa; T Yoshihara; N Mitsuma; M Doyu; G Sobue
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2000, Refereed, Not invited, Lead

Correlation of magnetic resonance imaging findings and histopathology of lesion distribution of spinal cord sarcoidosis at post-mortem.
Yasui K; Ishigaki S; Koike H; Ieda T; Yoshida M; Hashizume Y; Watanabe K; Sobue G
Neuropathology and applied neurobiology, Oct. 2000

Significance of membrane type 1 matrix metalloproteinase expression in breast cancer
S Ishigaki; M Toi; T Ueno; H Matsumoto; M Muta; M Koike; M Seiki
JAPANESE JOURNAL OF CANCER RESEARCH, May 1999, Refereed, Not invited, Lead

Metalloproteinases and tissue inhibitors of metalloproteinases
M Toi; S Ishigaki; T Tominaga
BREAST CANCER RESEARCH AND TREATMENT, 1998, Refereed, Not invited

APP遺伝子改変カニクイザルのアルツハイマー病脳脊髄液バイオマーカーの解析
柳沢大治郎; 守村敏史; 西村正樹; 遠山育夫; 依馬正次; 石垣診祐
日本生物学的精神医学会(Web), 2024

APPトランスジェニックカニクイザルの開発 脳脊髄液バイオマーカー
柳沢 大治郎; 守村 敏史; 西村 正樹; 遠山 育夫; 依馬 正次; 石垣 診祐
Dementia Japan, Oct. 2023

Aberrant Interaction Between FUS and SFPQ in Neurons in a Wide Range of FTLD Spectrum Diseases
石垣診祐
Brain and Nerve, 2021

Current therapeutic strategies for tauopathy
石垣診祐; 祖父江元
医学のあゆみ, Apr. 2020, Not refereed, Not invited

マーモセット脳で発現するタウのアイソフォームとリン酸化
カク安ニ; SHARMA Govinda; 木村妙子; 木村妙子; 塩澤誠司; 小林玲央奈; 小林玲央奈; 佐原成彦; 石橋みなか; 石垣診祐; 斎藤太郎; 安藤香奈絵; 村山繁雄; 長谷川成人; 祖父江元; 岡野栄之; 岡野栄之; 久永眞市; 久永眞市
日本生化学会大会(Web), 2019

タウisoformの成体神経新生における役割
石垣診祐; 石垣診祐; 岩出展行; 藤岡祐介; 遠藤邦幸; 河合香里; 石橋みなか; 勝野雅央; 渡辺宏久; 宮坂知宏; 祖父江元
臨床ストレス応答学会大会抄録集, 2018

The retention pattern of THK5351 pet imaging and functional network disruption associated with development of Alzheimer's disease
Yokoi T; Watanabe H; Yamaguchi H; Bagarinao E; Masuda M; Imai K; Ogura A; Ohdake R; Kawabata K; Hara K; Riku Y; Ishigaki S; Katsuno M; Kato K; Naganawa S; Okamura N; Miyao S; Yanai K; Sobue G
JOURNAL OF THE NEUROLOGICAL SCIENCES, 15 Oct. 2017, Not refereed, Not invited

【認知症の予防と対策】前頭側頭型認知症への新しいアプローチ
石垣 診祐; 祖父江 元
Medical Science Digest, Jun. 2016, Not refereed, Not invited

【認知症】病態生理 認知症の動物モデルupdate
石垣 診祐
最新医学, Mar. 2016, Not refereed, Not invited

【RNA疾患-最新の病態解析から治療法展望まで-】筋萎縮性側索硬化症におけるRNA制御異常
石垣 診祐; 祖父江 元
Medical Science Digest, Jun. 2014

FUSの機能喪失はタウisoformの制御を介してFTLDの高次機能異常に関与する
石垣診祐; 藤岡祐介; 岡戸春生; 渡辺宏久; 勝野雅央; 祖父江元
日本神経学会学術大会プログラム・抄録集, 2014

病態に根ざしたALSの新規治療法開発 変異SOD1(G93A)マウスにおけるc-Abl阻害剤の治療効果
祖父江元; 勝又竜; 石垣診祐; 勝野雅央; 勝又竜; 河合香織; 曽根淳; 足立弘明; 田中章景
神経変性疾患に関する調査研究班分科班「病態に根ざしたALSの新規治療法開発」 平成24年度 研究報告書, 2013

TDP-43の凝集体形成におけるRNA結合障害の関与
高木 伸之介; 井口 洋平; 石垣 診祐; 勝野 雅央; 田中 章景; 祖父江 元
臨床神経学, Dec. 2012

ALSにおけるFUS/TLSの質的機能喪失と病態 FUS/TLSの核内高分子複合体の機能解析から
石垣 診祐; 藤岡 祐介; 田中 章景; 祖父江 元
臨床神経学, Dec. 2012

Review/Advances in Neurological Therapeutics (2011). Motor Neuron Disease.
TANAKA FUMIAKI; IGUCHI YOHEI; IKENAKA KENSUKE; ISHIGAKI SHINSUKE; KATSUNO MASAHISA; SOBUE GEN
神経治療学, 25 Jul. 2012, Not refereed, Not invited

運動ニューロンにおけるALS関連変異FUS/TLSの機能障害
石垣 診祐; 藤岡 祐介; 田中 章景; 祖父江 元
臨床神経学, Dec. 2011

Review/Advances in Neurological Therapeutics (2010). Motor Neuron Disease
TANAKA FUMIAKI; IGUCHI YOHEI; ISHIGAKI SHINSUKE; KATSUNO MASAHISA; SOBUE GEN
神経治療学, 25 Jul. 2011, Not refereed, Not invited

神経変性とユビキチンリガーゼ
石垣診祐; 祖父江元
老年期痴呆研究会誌(Web), 2010, Not refereed, Not invited

Protein Homeostasisを解明する 小胞体ストレスと疾患 神経変性疾患の発症にかかわる小胞体ストレスのメカニズム
石垣診祐
実験医学, 01 Mar. 2009, Not refereed, Not invited

筋萎縮性側索硬化症の画期的診断・治療法に関する研究 遺伝子発現プロファイリングに基づくALSの病態解明・治療法開発・新規疾患モデルの開発
祖父江元; 田中章景; 和座雅浩; 丹羽淳一; 黄哲; 蒋月梅; 石垣診祐; 勝野雅央; 曽根淳; 井口洋平; 山田新一; 飯島正博; 山本正彦; 道勇学
筋萎縮性側索硬化症の画期的診断・治療法に関する研究 平成17-19年度 総合研究報告書, 2008

RNAi-mediated Gene Silencing Therapy for Motor Neuron Disease.
ISHIGAKI SHINSUKE; SOBUE GEN
神経治療学, 25 Jan. 2006, Not refereed, Not invited

運動ニューロン疾患Up‐to‐date
山本正彦; 石垣診祐; 勝野雅央; 祖父江元
Brain Nerve, 01 Apr. 2005, Not refereed, Not invited

Dorfinは変異SOD1のミトコンドリア蓄積の低減を介して神経細胞死を抑制する
田中 章景; 竹内 英之; 丹羽 淳一; 石垣 診祐; 菱川 望; 道勇 学; 祖父江 元
臨床神経学, Dec. 2004

ユビキチンと筋萎縮性側索硬化症(ALS)
石垣診祐
週刊医学のあゆみ, 02 Oct. 2004, Not refereed, Not invited

Crosstalk between Motor Neurons end Glial Cells in ALS.
ISHIGAKI SHINSUKE; SOBUE GEN
細胞工学, Apr. 2003, Not refereed, Not invited

運動ニューロン疾患の病態と今後の治療への展望
石垣診祐; 祖父江元
難病と在宅ケア, 01 Mar. 2003, Not refereed, Not invited

神経疾患と分子病態モデルをめぐるトピックス 酸化的ストレス障害 SOD1トランスジェニックマウスにおける遺伝子発現パターン
石垣診祐; 祖父江元
Clin Neurosci, 01 Feb. 2003, Not refereed, Not invited

マクロとミクロの疫学 臨床から遺伝子まで 脳神経領域 遺伝性神経疾患の遺伝疫学
石垣診祐; 服部直樹; 田中章景; 山本正彦; 祖父江元
現代医療, 10 Jan. 2003, Not refereed, Not invited

最近注目されてきた疾患・病態・治療 内科のトピックスを知る 神経・筋 神経疾患とアポトーシス
石垣診祐; 祖父江元
内科, 01 Jun. 2001, Not refereed, Not invited

分子インデックス法による中脳黒質の発現遺伝子プロファイル パーキンソン病(PD)病態関連分子群の探索
石垣 診祐; 丹羽 淳一; 道勇 学; 澤田 浩一; 田中 章景; 祖父江 元; 加藤 菊也
臨床神経学, Dec. 1999

分子インデックス法による筋萎縮性側索硬化症(ALS)病態関連分子群の探索
丹羽 淳一; 道 勇学; 石垣 診祐; 澤田 浩一; 田中 章景; 祖父江 元; 加藤 菊也
臨床神経学, Dec. 1999

HIVの急性感染期(acute infection)と診断され,抗HIV薬の投与を開始した1症例
石垣 診祐; 今村 顕史; 味澤 篤; 根岸 昌功; 増田 剛太
感染症学雑誌, Sep. 1998

Importance of tissue-infiltrating macrophage activation in breast cancer progression
M Toi; T Ueno; H Matsumoto; Y Yamamoto; S Ishigaki; T Tominaga
EUROPEAN JOURNAL OF CANCER, Sep. 1998, Not refereed, Not invited

Phase Separation in Living Cells
Ishigaki S, Contributor, Functional Properties of Phase Separation and Intranuclear Complex of FUS in the Pathogenesis of ALS/FTLD
Springer, Singapore., Oct. 2023
9789819948857

Apr. 2024, Present
神経化学学会

Apr. 2019, Present
神経病理学会

Apr. 1998, Present
日本内科学会

Society for Neuroscinece (SfN)

JAPAN SOCIETY FOR DEMENTIA RESEARCH

THE JAPAN NEUROSCIENCE SOCIETY

JAPANESE SOCIETY OF NEUROLOGY

Development of a Disease-Modifying Therapy for Alzheimer's Disease Based on Tau Isoform Regulation
Grant-in-Aid for Scientific Research (B)
Shiga University of Medical Science
01 Apr. 2025, 31 Mar. 2029

Therapeutics for 4R-Tauopathies through Long-acting Antisense Oligonucleotide
Shiga University of Medical Science
Apr. 2026, Mar. 2029

天然変性領域 (IDR) 形成を支えるスプライシング機構から俯瞰する相分離現象
基盤研究(B)
名古屋大学
01 Apr. 2021, 31 Mar. 2025

FTLDスペクトラムにおける核内RNP複合体の機能変化に基づく核酸医療の開発
基盤研究(B)
滋賀医科大学
01 Apr. 2021, 31 Mar. 2025

天然変性領域 (IDR) 形成を支えるスプライシング機構から俯瞰する相分離現象
基盤研究(B)
名古屋大学
01 Apr. 2021, 31 Mar. 2025

FTLDスペクトラムにおける核内RNP複合体の機能変化に基づく核酸医療の開発
基盤研究(B)
滋賀医科大学
Apr. 2021, Mar. 2025

Analysis of novel mechanisms of aging-related diseases focusing on Golgi stress signaling
Grant-in-Aid for Scientific Research (B)
Gifu University
01 Apr. 2019, 31 Mar. 2024

Development of oligonucleotide therapeutics targeting liquid-liquid phase separation for FTLD
Nagoya University Graduate School of Medicine
Apr. 2021, Mar. 2024

Development of novel translational test batteries using FTLD model marmosets
Nagoya University Graduate School of Medicine
Apr. 2021, Mar. 2024

Exploration of ER-phagy substrates involved in brain aging and its application to the control of neuronal senescence
Grant-in-Aid for Challenging Research (Exploratory)
Gifu University
30 Jul. 2020, 31 Mar. 2023

Common pathogenesis in a wide-range of FTLD spectrum including ALS/FTLD and tauopathies
Grant-in-Aid for Scientific Research (C)
Nagoya University
01 Apr. 2018, 31 Mar. 2021

多チャンネルプレーナ技術による生体組織分子解析とその神経疾患応用
Apr. 2015, Mar. 2020

Mechanism of tau protein aging and neurodegeneration
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
10 Jul. 2014, 31 Mar. 2019

Adult neurogenesis in the mouse models of ALS/FTLD
Grant-in-Aid for Scientific Research (C)
Nagoya University
01 Apr. 2015, 31 Mar. 2018

Elucidation of dysregulation of exocytosis in sporadic amyotrophic lateral sclerosis
Grant-in-Aid for Challenging Exploratory Research
Nagoya University
01 Apr. 2016, 31 Mar. 2017

Involvement of novel ubiquitin ligases in the pathogenic mechanism of Alzheimer's disease and drug discovery for fundamental therapeutic agent
Grant-in-Aid for Scientific Research (B)
01 Apr. 2012, 31 Mar. 2016

Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells
Grant-in-Aid for Challenging Exploratory Research
Nagoya University
01 Apr. 2012, 31 Mar. 2014

特願2024-129200, 液液相分離を制御するオリゴヌクレオチド
石垣 診祐; モニルザマン モハマド; 藤原 健志; 岡本 到; 閨 正博; 岡田 洋平; 武内 章英; 青木 正志; 秋山 徹也; 鈴木 直輝; 増田 章男; 岡野 栄之

特許7340794, 特願2018-127872, OLIGONUCLEOTIDES FOR CONTROLLING TAU SPLICING, AND USES THEREOF
祖父江 元; 石垣 診祐; 佐橋 健太郎; 遠藤 邦幸; 閨 正博; 藤原 健志; 松田 誠司

特許7307417, 特願2017-134890, TDP-43の発現量を調節するアンチセンスオリゴヌクレオチド及びその用途
永井義隆; 前田和宏; 武内敏秀; 閨 正博; 藤原 健志; 松田 誠司; 祖父江 元; 石垣 診祐; 佐橋 健太郎

特許第6994711号, 特開2019-037159, 特願2017-160962, 細胞内容物の回収方法および回収装置
高村 禅; 宇理須 恒雄; 石垣 診祐; 宇野 秀隆

特願2016-139308, 疾患モデル動物および疾患治療剤
祖父江 元; 石垣 診祐; 横井 聡

特願US 12/463,225, Methods For Treating Endoplasmic Reticulum (ER) Stress Disorders
Fumihiko Urano; Shinsuke Ishigaki; Sonya G. Fonesca