2014
日本病理学会学術研究賞

1995
北海道医学会賞

Pathogenicity of SARS-CoV-2 Omicron subvariants JN.1, EG.5.1, and BA.2.86.1 in immunologically naïve cynomolgus macaques.
Hirohito Ishigaki; Kenichi Otaki; Naoko Kitagawa; Hideaki Ishida; Hiraku Kokubu; Oahida Aktar; Hideji Otani; Masashi Shingai; Hiroshi Kida; Yasushi Itoh
Virology, 04 Aug. 2026

Case of concurrent ALS and human T-cell leukaemia virus type 1-associated myositis.
Toshika Hata; Nobuhiro Ogawa; Hiroyuki Yabata; Shuhei Kobashi; Misako Nakayama; Hirohito Ishigaki; Isamu Yamakawa; Yasushi Itoh; Ichizo Nishino; Makoto Urushitani
BMJ case reports, 07 Jul. 2026

Nuclear Speckle Protein SRRM2 Co-localized with Pathological Tau (pTauS396) in Neuronal and Glial Cells in Progressive Supranuclear Palsy.
Faris Hazwan Nazar; Aslina Pahrudin Arrozi; Tomoko Kato; Daijiro Yanagisawa; Yasushi Itoh; Ikuo Tooyama; Jean-Pierre Bellier
Acta histochemica et cytochemica, 27 Jun. 2026

Optimizing CRISPR precision in mouse embryos via microhomology-mediated end joining-dominant targeting.
Khanui Lkhagvadorj; Eiichi Okamura; Taito Taki; Hayate Suzuki; Akihiro Kuno; Yasushi Itoh; Seiya Mizuno; Knut Woltjen; Masatsugu Ema
Communications biology, 23 Mar. 2026, Refereed, Not invited

頭蓋内に生じた悪性末梢神経鞘腫の1剖検例
西村 凌征; 小橋 修平; 矢端 博行; 小川 暢弘; 石垣 宏仁; 森谷 鈴子; 伊藤 靖; 漆谷 真
臨床神経学, Mar. 2026

Reversible cystogenesis in juvenile primate ADPKD models: evidence from PKD1 heterozygous monkeys.
Shoma Matsumoto; Toshifumi Morimura; Kenichi Kobayashi; Keiichi Tsuji; Masataka Nakaya; Tomoyuki Tsukiyama; Ikuo Kawamoto; Takahiro Nakagawa; Etsuko Morishige; Koji Fukuda; Teppei Iwakiri; Kazuhiko Nozaki; Akihiro Kawauchi; Susumu Kageyama; Shinji Kume; Saori Nishio; Yasushi Itoh; Masatsugu Ema
Human molecular genetics, 23 Feb. 2026, Refereed

Suppression of the neutrophil-derived S100A8/A9 complex ameliorates doxorubicin-induced cardiomyopathy in non-human primates.
Fumiya Sawasaki; Akira Sato; Akio Shimizu; Shoma Matsumoto; Ikuo Kawamoto; Mitsuru Murase; Iori Itagaki; Hideaki Tsuchiya; Hirohito Ishigaki; Naoko Ueda; Issa Toyoda; Yasushi Itoh; Daisuke Okuzaki; Masatsugu Ema; Hisakazu Ogita
Biochemical pharmacology, Jan. 2026, Refereed

Vaccinia virus-based SARS-CoV-2 vaccine prevents lung immunopathology without antibody-dependent enhancement in female rhesus macaques.
Cong Thanh Nguyen; Misako Nakayama; Fumihiko Yasui; Hirohito Ishigaki; Kenichi Otaki; Naoki Yamamoto; Takahiro Sanada; Kenzaburo Yamaji; Tomoko Honda; Yusuke Matsumoto; Naoko Kitagawa; Koji Ishii; Tomoe Kusayanagi; Yoshiki Yagi; Michinori Kohara; Yasushi Itoh
Virology, 18 Dec. 2025, Refereed, Not invited

Characterization of H5N1 high pathogenicity avian influenza virus belonging to clade 2.3.4.4b isolated from Ezo red fox in Japan in a mouse model.
Shintaro Shichinohe; Takahiro Hiono; Yasushi Itoh; Kosuke Takada; Yurie Kida; Pei Wang; Daisuke Motooka; Norikazu Isoda; Ayato Takada; Yoshihiro Sakoda; Tokiko Watanabe
Microbiology spectrum, 26 Nov. 2025, Refereed, Not invited

Monoclonal antibodies against human TMPRSS2 prevent infection by any SARS-CoV-2 variant.
Michishige Harada; Takehisa Matsumoto; Mizuki Yamamoto; Jin Goda; Akiko Idei; Kenichi Ohtaki; Natsuki Kojima; Natsumi Yoneda; Kosuke Miyauchi; Kazushige Katsura; Mariko Ikeda; Kazuharu Hanada; Yoshiko Ishizuka-Katsura; Toshiaki Hosaka; Tamao Hisano; Toshie Kaizuka; Takako Yamamoto; Masashi Matsuda; Manabu Nakayama; Akiko Sugimoto-Ishige; Machie Sakuma; Rina Hashimoto; Kazuo Takayama; Misako Nakayama; Cong Thanh Nguyen; Hirohito Ishigaki; Yasushi Itoh; Yoshinobu Hashizume; Minoru Yoshida; Yasushi Kawaguchi; Makoto Takeda; Haruhiko Koseki; Mikako Shirouzu; Jun-Ichiro Inoue; Takashi Saito
iScience, 19 Sep. 2025, Refereed, Not invited

デキサメタゾンによる免疫抑制状態のマウスとカニクイザルモデルにおけるインフルエンザ完全粒子ワクチンの効果
伊藤 靖; 國府 拓; 大滝 賢一; 石垣 宏仁
臨床とウイルス, Sep. 2025

マウスを用いた弱毒ワクシニアウイルスDIsのmpoxに対する有効性の解析
大滝 賢一; 安井 文彦; 石垣 宏仁; 北川 直子; 石井 孝司; 小原 道法; 伊藤 靖
臨床とウイルス, Sep. 2025

Long-term efficacy of an inactivated H5N1 whole-particle influenza vaccine in nonhuman primates.
Misako Nakayama; Naoko Kitagawa; Cong Thanh Nguyen; Takako Sasamura; Kyoko Takashima; Hirohito Ishigaki; Hideaki Ishida; Saori Suzuki; Yoshihiro Sakoda; Mai Quynh Le; Hiroshi Kida; Kazumasa Ogasawara; Yasushi Itoh
NPJ vaccines, 23 Jul. 2025, Refereed, Not invited, Corresponding

Translational research on pandemic virus infection using nonhuman primate models.
Hirohito Ishigaki; Yasushi Itoh
Virology, May 2025, Refereed, Invited, Corresponding

ARNAX is an ideal adjuvant for COVID-19 vaccines to enhance antigen-specific CD4+ and CD8+ T-cell responses and neutralizing antibody induction.
Tomomi Kawakita; Toshiki Sekiya; Yayoi Kameda; Naoki Nomura; Marumi Ohno; Chimuka Handabile; Akari Yamaya; Hideo Fukuhara; Yuki Anraku; Shunsuke Kita; Shinsuke Toba; Hirotake Tsukamoto; Tomohiro Sawa; Hiroyuki Oshiumi; Yasushi Itoh; Katsumi Maenaka; Akihiko Sato; Hirofumi Sawa; Yasuhiko Suzuki; Lorena E Brown; David C Jackson; Hiroshi Kida; Misako Matsumoto; Tsukasa Seya; Masashi Shingai
Journal of Virology, 15 Apr. 2025, Refereed

SARS-CoV-2 S遺伝子を持つ弱毒化ワクシニアウイルスワクチン接種による免疫は抗体依存性増強を起こさない(Attenuated vaccina virus carrying the SARS-CoV-2 S gene reduces virus replication without ADE)
石垣 宏仁; 仲山 美沙子; ぐえん・たんこん; 安井 文彦; 小原 道法; 伊藤 靖
日本病理学会会誌, Mar. 2025

胸水貯留により発症し、病理解剖にて確定診断した偽中皮腫性肺癌(扁平上皮癌)の一例
土佐 泰智; 杉村 周亮; 石垣 宏仁; 伊藤 靖
日本病理学会会誌, Mar. 2025

Histopathological Investigation of Progressive Encephalomyelitis with Rigidity and Myoclonus: An Autopsy Case Characterized by Oculomotor Dysfunction and Autonomic Failure.
Hiroyuki Yabata; Ryutaro Nakamura; Seiji Sugiyama; Yoshitaka Tamaki; Isamu Yamakawa; Shiori Onoda; Hirohito Ishigaki; Toshimasa Ikeda; Akio Akagi; Yasushi Itoh; Ryoji Kushima; Mari Yoshida; Yasushi Iwasaki; Makoto Urushitani
Internal medicine (Tokyo, Japan), 15 Feb. 2025, Refereed

A hemoperfusion column selectively adsorbs LAP+ lymphocytes to improve anti-tumor immunity and survival of tumor-bearing rats.
Kazuo Teramoto; Yuji Ueda; Ryosuke Murai; Kazumasa Ogasawara; Misako Nakayama; Hirohito Ishigaki; Yasushi Itoh
PloS one, Mar. 2025, Refereed, Not invited

デキサメタゾンを投与したマウスに対する完全粒子ワクチンとスプリットワクチンの効果の比較
國府 拓; 石垣 宏仁; 北川 直子; 大滝 賢一; 伊藤 靖
日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集, Dec. 2024

Surgical outcome in patients with lung adenocarcinoma with mucin.
Keiko Ueda; Yo Kawaguchi; Yasushi Itoh; Daigo Ishihara; Hiroki Saito; Takuya Shiratori; Keigo Okamoto; Yoko Kataoka; Mayumi Ohshio; Yasuhiko Ohshio; Jun Hanaoka
General thoracic and cardiovascular surgery, 15 Nov. 2024, Refereed

弱毒ワクシニアウイルスDIs接種カニクイザル血清のエムポックスウイルス中和能の解析
大滝 賢一; 安井 文彦; 北川 直子; 石垣 宏仁; 石井 孝司; 小原 道法; 伊藤 靖
臨床とウイルス, Oct. 2024

Immunohistochemical Study of Human Mitochondrial Ferritin in the Substantia Nigra Following Subarachnoid Hemorrhage.
Shogo Takahata; Tomoko Kato; Daijiro Yanagisawa; Haruka Tsubaki; Zulzikry Hafiz Abu Bakar; Ken-Ichi Mukaisho; Yasushi Itoh; Ikuo Tooyama
Acta histochemica et cytochemica, 28 Jun. 2024, Refereed

LAP陽性T細胞吸着材カラムを用いるがん治療方法の開発
寺本 和雄; 上田 祐二; 小笠原 一誠; 村井 亮介; 仲山 美沙子; 石垣 宏仁; 伊藤 靖
日本がん免疫学会総会・日本バイオセラピィ学会学術集会総会合同大会プログラム・抄録集, Jun. 2024

Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection in cynomolgus macaques.
Cong Thanh Nguyen; Misako Nakayama; Hirohito Ishigaki; Yoshinori Kitagawa; Akemi Kakino; Marumi Ohno; Masashi Shingai; Yasuhiko Suzuki; Tatsuya Sawamura; Hiroshi Kida; Yasushi Itoh
Virology, Jun. 2024, Refereed, Not invited, Corresponding

SARS-CoV-2感染非ヒト霊長類における嗅上皮の変化と嗅神経を介した頭蓋内感染の可能性
清水 猛史; 清水 志乃; 仲山 美沙子; 石垣 宏仁; Nguyen Thanh Cong; 北川 善紀; 伊藤 靖
耳鼻咽喉科ニューロサイエンス, May 2024

SARS-CoV-2 induces inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway in non-human primates.
Shino Shimizu; Misako Nakayama; Cong Thanh Nguyen; Hirohito Ishigaki; Yoshinori Kitagawa; Fumihiko Yasui; Yoshiki Yagi; Tomoe Kusayanagi; Michinori Kohara; Yasushi Itoh; Ichiro Tojima; Hideaki Kouzaki; Takeshi Shimizu
Journal of neuroimmunology, 15 Feb. 2024, Refereed

Th1型免疫によって誘導されるカニクイザルコラーゲン誘導性関節炎モデルの病理組織像(The histopathology of collagen-induced arthritis induced by Th1-type immunity in cynomolgus macaques)
石垣 宏仁; 仲山 美沙子; 伊藤 靖
日本病理学会会誌, Feb. 2024

カニクイザルCD4+CD8+double positive T細胞は、ヒトCD4 high CD8 low double positive T細胞に類似する
高橋 諒多; 笹村 孝子; 石垣 宏仁; 伊藤 靖
日本病理学会会誌, Feb. 2024

MHC-DRB alleles with amino acids Val11, Phe13, and the shared epitopes promote collagen-induced arthritis and a rapid IgG1 response in Filipino cynomolgus macaques.
Hirohito Ishigaki; Sayaka Ito; Takako Sasamura; Hideaki Ishida; Misako Nakayama; Cong Thanh Nguyen; Takaaki Kinoshita; Shingo Suzuki; Chizuru Iwatani; Hideaki Tsuchiya; Hisashi Yamanaka; Jerzy K Kulski; Yasushi Itoh; Takashi Shiina
HLA, Jan. 2024, Refereed, Not invited

Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19.
Eri Kawakami; Norikazu Saiki; Yosuke Yoneyama; Chiharu Moriya; Mari Maezawa; Shuntaro Kawamura; Akiko Kinebuchi; Tamaki Kono; Masaaki Funata; Ayaka Sakoda; Shigeru Kondo; Takeshi Ebihara; Hisatake Matsumoto; Yuki Togami; Hiroshi Ogura; Fuminori Sugihara; Daisuke Okuzaki; Takashi Kojima; Sayaka Deguchi; Sebastien Vallee; Susan McQuade; Rizwana Islam; Madhusudan Natarajan; Hirohito Ishigaki; Misako Nakayama; Cong Thanh Nguyen; Yoshinori Kitagawa; Yunheng Wu; Kensaku Mori; Takayuki Hishiki; Tomohiko Takasaki; Yasushi Itoh; Kazuo Takayama; Yasunori Nio; Takanori Takebe
Cell stem cell, 05 Oct. 2023, Refereed

ワクチン開発における霊長類モデルの課題と展望
伊藤靖
炎症と免疫, Jul. 2023, Not refereed, Invited

ウイルス感染による内皮細胞障害におけるNAD分解酵素CD38と低酸素誘導因子HIFの役割
コン タン グエン; 伊藤靖; 角田郁生
メディカル・サイエンス・ダイジェスト, Jul. 2023, Not refereed, Invited

Inactivation of SARS-CoV-2 variants by nitrogen-doped titanium dioxide loaded with metals as visible-light photocatalysts.
Takashi Matsuyama; Shu Saeki; Satoru Kosaka; Yoriko Matsuoka; Yoshifumi Aoki; Yasushi Itoh; Takao Imaeda
Biotechnology letters, Apr. 2023, Refereed

インフルエンザ不活化全粒子ワクチンはB細胞の体細胞高頻度突然変異を誘導する。
塩原 正規; 仲山 美沙子; 石垣 宏仁; 伊藤 靖
日本病理学会会誌, Mar. 2023

サルにおけるH5N1不活化全粒子ワクチン接種5年後の肺炎予防効果
仲山 美沙子; 北川 直子; 石垣 宏仁; Nguyen Thanh Cong; 石田 英明; 鈴木 紗織; 小笠原 一誠; 伊藤 靖
日本病理学会会誌, Mar. 2023

慢性呼吸器疾患患者由来の気道オルガノイドにおけるインフルエンザおよび新型コロナウイルス受容体の発現
森河 友里; 仲山 美沙子; 笹村 孝子; 石垣 宏仁; 伊藤 靖
日本病理学会会誌, Mar. 2023

「感染・免疫研究の新潮流」 非ヒト霊長類の嗅上皮から嗅球におけるSARS-CoV-2感染の病態
清水 志乃; 仲山 美沙子; 石垣 宏仁; Nguyen Thanh Cong; 北川 善紀; 伊藤 靖; 清水 猛史
日本耳鼻咽喉科免疫アレルギー感染症学会抄録集, Mar. 2023

インフルエンザ不活化全粒子ワクチンはB細胞の体細胞高頻度突然変異を誘導する。
塩原 正規; 仲山 美沙子; 石垣 宏仁; 伊藤 靖
日本病理学会会誌, Mar. 2023

サルにおけるH5N1不活化全粒子ワクチン接種5年後の肺炎予防効果
仲山 美沙子; 北川 直子; 石垣 宏仁; Nguyen Thanh Cong; 石田 英明; 鈴木 紗織; 小笠原 一誠; 伊藤 靖
日本病理学会会誌, Mar. 2023

慢性呼吸器疾患患者由来の気道オルガノイドにおけるインフルエンザおよび新型コロナウイルス受容体の発現
森河 友里; 仲山 美沙子; 笹村 孝子; 石垣 宏仁; 伊藤 靖
日本病理学会会誌, Mar. 2023

「感染・免疫研究の新潮流」 非ヒト霊長類の嗅上皮から嗅球におけるSARS-CoV-2感染の病態
清水 志乃; 仲山 美沙子; 石垣 宏仁; Nguyen Thanh Cong; 北川 善紀; 伊藤 靖; 清水 猛史
日本耳鼻咽喉科免疫アレルギー感染症学会抄録集, Mar. 2023

Assessing the pyrogenicity of whole influenza virus particle vaccine in cynomolgus macaques.
Marumi Ohno; Masataka Sagata; Toshiki Sekiya; Naoki Nomura; Masashi Shingai; Masafumi Endo; Kazuhiko Kimachi; Saori Suzuki; Cong Thanh Nguyen; Misako Nakayama; Hirohito Ishigaki; Kazumasa Ogasawara; Yasushi Itoh; Yoichiro Kino; Hiroshi Kida
Vaccine, 16 Jan. 2023, Refereed, Not invited

Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.
Masaru Takeshita; Hidehiro Fukuyama; Katsuhiko Kamada; Takehisa Matsumoto; Chieko Makino-Okamura; Tomomi Uchikubo-Kamo; Yuri Tomabechi; Kazuharu Hanada; Saya Moriyama; Yoshimasa Takahashi; Hirohito Ishigaki; Misako Nakayama; Cong Thanh Nguyen; Yoshinori Kitagawa; Yasushi Itoh; Masaki Imai; Tadashi Maemura; Yuri Furusawa; Hiroshi Ueki; Kiyoko Iwatsuki-Horimoto; Mutsumi Ito; Seiya Yamayoshi; Yoshihiro Kawaoka; Mikako Shirouzu; Makoto Ishii; Hideyuki Saya; Yasushi Kondo; Yuko Kaneko; Katsuya Suzuki; Koichi Fukunaga; Tsutomu Takeuchi
iScience, 22 Dec. 2022, Refereed, Not invited

サルにおける嗅上皮から嗅神経を介したSARS-CoV-2の頭蓋内感染について
清水 志乃; 仲山 美沙子; 石垣 宏仁; Nguyen Thanh Cong; 北川 善紀; 伊藤 靖; 清水 猛史
日本鼻科学会会誌, Oct. 2022

Immunization with inactivated whole virus particle influenza virus vaccines improves the humoral response landscape in cynomolgus macaques.
Brendon Y Chua; Toshiki Sekiya; Marios Koutsakos; Naoki Nomura; Louise C Rowntree; Thi H O Nguyen; Hayley A McQuilten; Marumi Ohno; Yuki Ohara; Tomohiro Nishimura; Masafumi Endo; Yasushi Itoh; Jennifer R Habel; Kevin J Selva; Adam K Wheatley; Bruce D Wines; P Mark Hogarth; Stephen J Kent; Amy W Chung; David C Jackson; Lorena E Brown; Masashi Shingai; Katherine Kedzierska; Hiroshi Kida
PLoS pathogens, 07 Oct. 2022, Refereed, Not invited

AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination.
Shin-Ichi Tsukumo; Poorani Ganesh Subramani; Noé Seija; Mizuho Tabata; Yoichi Maekawa; Yuya Mori; Chieko Ishifune; Yasushi Itoh; Mineto Ota; Keishi Fujio; Javier M Di Noia; Koji Yasutomo
Science advances, 26 Aug. 2022, Refereed, Not invited

Inactivated whole influenza virus particle vaccines induce neutralizing antibodies with an increase in immunoglobulin gene subclones of B-lymphocytes in cynomolgus macaques.
Masanori Shiohara; Saori Suzuki; Shintaro Shichinohe; Hirohito Ishigaki; Misako Nakayama; Naoki Nomura; Masashi Shingai; Toshiki Sekiya; Marumi Ohno; Sayaka Iida; Naoko Kawai; Mamiko Kawahara; Junya Yamagishi; Kimihito Ito; Ryotarou Mitsumata; Tomio Ikeda; Kenji Motokawa; Tomoyoshi Sobue; Hiroshi Kida; Kazumasa Ogasawara; Yasushi Itoh
Vaccine, 26 Jun. 2022, Refereed, Not invited

Fc-modified SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models
Masaru Takeshita; Hidehiro Fukuyama; Katsuhiko Kamada; Takehisa Matsumoto; Chieko Makino-Okamura; Tomomi Uchikubo-Kamo; Yuri Tomabechi; Kazuharu Hanada; Saya Moriyama; Yoshimasa Takahashi; Hirohito Ishigaki; Misako Nakayama; Cong Thanh Nguyen; Yoshinori Kitagawa; Yasushi Itoh; Masaki Imai; Tadashi Maemura; Yuri Furusawa; Hiroshi Ueki; Kiyoko Iwatsuki-Horimoto; Mutsumi Ito; Seiya Yamayoshi; Yoshihiro Kawaoka; Mikako Shirouzu; Makoto Ishii; Hideyuki Saya; Yasushi Kondo; Yuko Kaneko; Katsuya Suzuki; Koichi Fukunaga; Tsutomu Takeuchi
22 Jun. 2022, URL

An attenuated vaccinia vaccine encoding the SARS-CoV-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human ACE2 transgenic mice from SARS-CoV-2 and its variants
Hirohito Ishigaki; Fumihiko Yasui; Misako Nakayama; Akinori Endo; Naoki Yamamoto; Kenzaburo Yamaji; Cong Thanh Nguyen; Yoshinori Kitagawa; Takahiro Sanada; Tomoko Honda; Tsubasa Munakata; Masahiko Higa; Sakiko Toyama; Risa Kono; Asako Takagi; Yusuke Matsumoto; Kaori Hayashi; Masanori Shiohara; Koji Ishii; Yasushi Saeki; Yasushi Itoh; Michinori Kohara
13 Jun. 2022, URL

Infection with the SARS-CoV-2 B.1.351 variant is lethal in aged BALB/c mice
Fumihiko Yasui; Yusuke Matsumoto; Naoki Yamamoto; Takahiro Sanada; Tomoko Honda; Tsubasa Munakata; Yasushi Itoh; Michinori Kohara
Scientific Reports, Mar. 2022, Refereed, Not invited

Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model
Koji Terada; Kenta Kondo; Hirohito Ishigaki; Ayaka Nagashima; Hiroki Satooka; Seiji Nagano; Kyoko Masuda; Teruhisa Kawamura; Takako Hirata; Kazumasa Ogasawara; Yasushi Itoh; Hiroshi Kawamoto; Yasutoshi Agata
Molecular Therapy - Oncolytics, Mar. 2022, Refereed, Not invited

An attenuated vaccinia vaccine encoding the severe acute respiratory syndrome coronavirus-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human angiotensin-converting enzyme 2 transgenic mice from severe acute respiratory syndrome coronavirus-2 and its variants.
Hirohito Ishigaki; Fumihiko Yasui; Misako Nakayama; Akinori Endo; Naoki Yamamoto; Kenzaburo Yamaji; Cong Thanh Nguyen; Yoshinori Kitagawa; Takahiro Sanada; Tomoko Honda; Tsubasa Munakata; Masahiko Higa; Sakiko Toyama; Risa Kono; Asako Takagi; Yusuke Matsumoto; Aya Koseki; Kaori Hayashi; Masanori Shiohara; Koji Ishii; Yasushi Saeki; Yasushi Itoh; Michinori Kohara
Frontiers in microbiology, 18 Nov. 2022, Refereed, Not invited, Corresponding

Lectin Staining to Detect Human and Avian Influenza Virus Receptors in the Airway of Nonhuman Primates.
Misako Nakayama; Yasushi Itoh
Methods in molecular biology (Clifton, N.J.), 2022, Invited, Last

Detection of Sialic Acids on the Cell Surface Using Flow Cytometry.
Hirohito Ishigaki; Yasushi Itoh
Methods in molecular biology (Clifton, N.J.), 2022

Establishment of a nonhuman primate model for development of vaccines and anti-viral drugs against COVID-19.
Yasushi Itoh
Translational and Regulatory Sciences, Dec. 2021, Refereed, Invited

Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models
Makoto Saito; Yasushi Itoh; Fumihiko Yasui; Tsubasa Munakata; Daisuke Yamane; Makoto Ozawa; Risa Ito; Takayuki Katoh; Hirohito Ishigaki; Misako Nakayama; Shintaro Shichinohe; Kenzaburo Yamaji; Naoki Yamamoto; Ai Ikejiri; Tomoko Honda; Takahiro Sanada; Yoshihiro Sakoda; Hiroshi Kida; Thi Quynh Mai Le; Yoshihiro Kawaoka; Kazumasa Ogasawara; Kyoko Tsukiyama-Kohara; Hiroaki Suga; Michinori Kohara
Nature Communications, Dec. 2021, Refereed, Not invited, Lead

Potent priming by inactivated whole influenza virus particle vaccines is linked to viral RNA uptake into antigen presenting cells.
Masashi Shingai; Naoki Nomura; Toshiki Sekiya; Marumi Ohno; Daisuke Fujikura; Chimuka Handabile; Ryosuke Omori; Yuki Ohara; Tomohiro Nishimura; Masafumi Endo; Kazuhiko Kimachi; Ryotarou Mitsumata; Tomio Ikeda; Hiroki Kitayama; Hironori Hatanaka; Tomoyoshi Sobue; Fumihito Muro; Saori Suzuki; Cong Thanh Nguyen; Hirohito Ishigaki; Misako Nakayama; Yuya Mori; Yasushi Itoh; Marios Koutsakos; Brendon Y Chua; Katherine Kedzierska; Lorena E Brown; David C Jackson; Kazumasa Ogasawara; Yoichiro Kino; Hiroshi Kida
Vaccine, 29 Jun. 2021, Refereed, Not invited

Development and Characterization of a Highly Sensitive NanoLuciferase-Based Immunoprecipitation System for the Detection of Anti-Influenza Virus HA Antibodies.
Tomoko Honda; Sumiko Gomi; Daisuke Yamane; Fumihiko Yasui; Takuya Yamamoto; Tsubasa Munakata; Yasushi Itoh; Kazumasa Ogasawara; Takahiro Sanada; Kenzaburo Yamaji; Yasuhiro Yasutomi; Kyoko Tsukiyama-Kohara; Michinori Kohara
mSphere, 12 May 2021, Refereed, Not invited

No Tumorigenicity of Allogeneic Induced Pluripotent Stem Cells in Major Histocompatibility Complex-matched Cynomolgus Macaques
Hirohito Ishigaki; Van Loi Pham; Jun Terai; Takako Sasamura; Cong Thanh Nguyen; Hideaki Ishida; Junko Okahara; Shin Kaneko; Takashi Shiina; Misako Nakayama; Yasushi Itoh; Kazumasa Ogasawara
CELL TRANSPLANTATION, Feb. 2021, Refereed, Not invited

Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques
Hirohito Ishigaki; Misako Nakayama; Yoshinori Kitagawa; Cong Thanh Nguyen; Kaori Hayashi; Masanori Shiohara; Bin Gotoh; Yasushi Itoh
Virology, Feb. 2021, Refereed, Not invited

Immune profiling of influenza-specific B- and T-cell responses in macaques using flow cytometry-based assays.
Marios Koutsakos; Toshiki Sekiya; Brendon Y Chua; Thi Hoang Oanh Nguyen; Adam K Wheatley; Jennifer A Juno; Marumi Ohno; Naoki Nomura; Yuki Ohara; Tomohiro Nishimura; Masafumi Endo; Saori Suzuki; Hirohito Ishigaki; Misako Nakayama; Cong T Nguyen; Yasushi Itoh; Masashi Shingai; Kazumasa Ogasawara; Yoichiro Kino; Stephen J Kent; David C Jackson; Lorena E Brown; Hiroshi Kida; Katherine Kedzierska
Immunology and Cell Biology, Jan. 2021, Refereed, Not invited

Efficacy of a cap-dependent endonuclease inhibitor and neuraminidase inhibitors against H7N9 highly pathogenic avian influenza virus causing severe viral pneumonia in cynomolgus macaques.
Saori Suzuki; Cong Thanh Nguyen; Ayako Ogata-Nakahara; Akihiro Shibata; Hiroyuki Osaka; Hirohito Ishigaki; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida; Kazumasa Ogasawara; Yasushi Itoh
Antimicrobial Agents and Chemotherapy, 30 Dec. 2020, Refereed, Not invited

Characterization of tumour-infiltrating lymphocytes in a tumour rejection cynomolgus macaque model
Hiroki Satooka; Hirohito Ishigaki; Kagefumi Todo; Koji Terada; Yasutoshi Agata; Yasushi Itoh; Kazumasa Ogasawara; Takako Hirata
Scientific Reports, Dec. 2020, Refereed, Not invited, URL

H7N9高病原性鳥インフルエンザウイルスに対するバロキサビルの有効性評価および免疫反応の解析
鈴木 紗織; Nguyen Thanh Cong; 緒方 綾子[中原]; 石垣 宏仁; 仲山 美沙子; 伊藤 靖
日本獣医学会学術集会講演要旨集, Oct. 2020

カニクイザルの腫瘍浸潤T細胞から腫瘍殺傷能を有するTCR遺伝子を単離する
近藤 健太; 寺田 晃士; 石垣 宏仁; 里岡 大樹; 永野 誠治; 増田 喬子; 平田 多佳子; 小笠原 一誠; 伊藤 靖; 河本 宏; 縣 保年
日本がん免疫学会総会プログラム・抄録集, Sep. 2020

Embryonal Carcinoma and Glioblastoma Cell Lines Derived from Monkey Induced Pluripotent Stem Cells.
Hirohito Ishigaki; Yasushi Itoh
Methods in molecular biology (Clifton, N.J.), 25 Aug. 2020, Invited, Last

The Natural History of Spontaneously Occurred Endometriosis in Cynomolgus Monkeys by Monthly Follow-Up Laparoscopy for Two Years.
Kaori Hayashi; Misako Nakayama; Chizuru Iwatani; Hideaki Tsuchiya; Shinichiro Nakamura; Kosuke Nonoguchi; Yasushi Itoh; Shunichiro Tsuji; Hirohito Ishigaki; Takahide Mori; Takashi Murakami; Kazumasa Ogasawara
The Tohoku journal of experimental medicine, Aug. 2020, Refereed, Not invited

Efficacy of neuraminidase inhibitors against H5N6 highly pathogenic avian influenza virus in a non-human primate model.
Cong Thanh Nguyen; Saori Suzuki; Yasushi Itoh; Hirohito Ishigaki; Misako Nakayama; Kaori Hayashi; Keita Matsuno; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida; Kazumasa Ogasawara
Antimicrobial agents and chemotherapy, 13 Apr. 2020, Refereed, Not invited

Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza a virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution.
Saori Suzuki; Shintaro Shichinohe; Yasushi Itoh; Misako Nakayama; Hirohito Ishigaki; Yuya Mori; Ayako Ogata-Nakahara; Cong Thanh Nguyen; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida; Kazumasa Ogasawara
Antiviral research, 06 Apr. 2020, Refereed, Not invited

カニクイザルを用いたH7N9亜型高病原性鳥インフルエンザウイルスの病原性解析
緒方 綾子; 鈴木 紗織; グエン・タンコン; 伊藤 靖; 石垣 宏仁; 仲山 美沙子; 小笠原 一誠
日本病理学会会誌, Mar. 2020

カニクイザルを用いた組織適合抗原複合体一致他家iPS細胞移植においてteratomaは形成されない
石垣 宏仁; 寺井 淳; 仲山 美沙子; 伊藤 靖; 小笠原 一誠
日本病理学会会誌, Mar. 2020

カニクイザルを用いたH7N9亜型高病原性鳥インフルエンザウイルスの病原性解析
緒方 綾子; 鈴木 紗織; グエン・タンコン; 伊藤 靖; 石垣 宏仁; 仲山 美沙子; 小笠原 一誠
日本病理学会会誌, Mar. 2020

Efficacy of clarithromycin against H5N1 and H7N9 avian influenza A virus infection in cynomolgus monkeys
Arikata M; Itoh Y; Shichinohe S; Nakayama M; Ishigaki H; Kinoshita T; Le QM; Kawaoka Y; Ogasawara K; Shimizu T
Antiviral Research, Nov. 2019, Refereed, Not invited, Corresponding

Histological analysis of fundic gland polyps secondary to PPI therapy.
Fukuda M; Ishigaki H; Sugimoto M; Mukaisho KI; Matsubara A; Ishida H; Moritani S; Itoh Y; Sugihara H; Andoh A; Ogasawara K; Murakami K; Kushima R
Histopathology, Oct. 2019, Refereed, Not invited

PKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes.
Salman Mahmud Siddique; Koji Kubouchi; Yuka Shinmichi; Nana Sawada; Reiko Sugiura; Yasushi Itoh; Shunsuke Uehara; Kanae Nishimura; Shunsuke Okamura; Hiroyuki Ohsaki; Shingo Kamoshida; Yusuke Yamashita; Shinobu Tamura; Takashi Sonoki; Hiroshi Matsuoka; Tomoo Itoh; Hideyuki Mukai
Scientific reports, 27 Sep. 2019, Refereed, Not invited

LAP陽性細胞吸着カラムの癌治療への応用(The application of the adsorbent for LAP positive T cells to cancer therapy)
寺本 和雄; 石垣 宏仁; 仲山 美沙子; 伊藤 靖; 小笠原 一誠
日本癌学会総会記事, Sep. 2019

カニクイザルを用いたH5N6亜型高病原性鳥インフルエンザウイルスによる重症肺炎の解析
伊藤 靖; Nguyen Thanh Cong; 鈴木 紗織; 石垣 宏仁; 仲山 美沙子; 小笠原 一誠
日本病理学会会誌, Apr. 2019

プロトンポンプ阻害薬内服患者における胃底腺ポリープの組織学的特徴とポリープ増大因子の検討
福田 昌英; 石垣 宏仁; 松原 亜季子; 森谷 鈴子; 向所 賢一; 杉原 洋行; 伊藤 靖; 小笠原 一誠; 村上 和成; 九嶋 亮治
日本病理学会会誌, Apr. 2019

Inactivated whole virus particle vaccine with potent immunogenicity and limited IL-6 production is ideal for influenza
Toshiki Sekiya; Edin J Mifsud; Marumi Ohno; Naoki Nomura; Mayumi Sasada; Daisuke Fujikura; Takuji Daito; Masashi Shingai; Yuki Ohara; Tomohiro Nishimura; Masafumi Endo; Ryotarou Mitsumata; Tomio Ikeda; Hironori Hatanaka; Hiroki Kitayama; Kenji Motokawa; Tomoyoshi Sobue; Saori Suzuki; Yasushi Itoh; Lorena E Brown; Kazumasa Ogasawara; Yoichiro Kino; Hiroshi Kida
Vaccine, Mar. 2019, Refereed, Not invited

Prediction of intravesical recurrence of non-muscle-invasive bladder cancer by evaluation of intratumoral Foxp3+ T cells in the primary transurethral resection of bladder tumor specimens.
Ryosuke Murai; Yasushi Itoh; Susumu Kageyama; Misako Nakayama; Hirohito Ishigaki; Kazuo Teramoto; Mitsuhiro Narita; Tetsuya Yoshida; Keiji Tomita; Ken-ichi Kobayashi; Akinori Wada; Masayuki Nagasawa; Shigehisa Kubota; Kazumasa Ogasawara; Akihiro Kawauchi
PLoS One, Sep. 2018, Refereed, Not invited

Transplantation of iPS-Derived Tumor Cells with a Homozygous MHC Haplotype Induces GRP94 Antibody Production in MHC-Matched Macaques
Hirohito Ishigaki; Toshinaga Maeda; Hirokazu Inoue; Tsuyoshi Akagi; Takako Sasamura; Hideaki Ishida; Toshiro Inubushi; Junko Okahara; Takashi Shiina; Misako Nakayama; Yasushi Itoh; Kazumasa Ogasawara
CANCER RESEARCH, Nov. 2017, Refereed, Not invited

Emergence of Oseltamivir-Resistant H7N9 Influenza Viruses in Immunosuppressed Cynomolgus Macaques
Maki Kiso; Kiyoko Iwatsuki-Horimoto; Seiya Yamayoshi; Ryuta Uraki; Mutsumi Ito; Noriko Nakajima; Shinya Yamada; Masaki Imai; Eiryo Kawakami; Yuriko Tomita; Satoshi Fukuyama; Yasushi Itoh; Kazumasa Ogasawara; Tiago J. S. Lopes; Tokiko Watanabe; Louise H. Moncla; Hideki Hasegawa; Thomas C. Friedrich; Gabriele Neumann; Yoshihiro Kawaoka
JOURNAL OF INFECTIOUS DISEASES, Sep. 2017, Refereed, Not invited

MHC matching improves engraftment of iPSC-derived neurons in non-human primates
Asuka Morizane; Tetsuhiro Kikuchi; Takuya Hayashi; Hiroshi Mizuma; Sayuki Takara; Hisashi Doi; Aya Mawatari; Matthew F. Glasser; Takashi Shiina; Hirohito Ishigaki; Yasushi Itoh; Keisuke Okita; Emi Yamasaki; Daisuke Doi; Hirotaka Onoe; Kazumasa Ogasawara; Shinya Yamanaka; Jun Takahashi
NATURE COMMUNICATIONS, Aug. 2017, Refereed, Not invited

Potential risk of repeated nasal vaccination that induces allergic reaction with mucosal IgE and airway eosinophilic infiltration in cynomolgus macaques infected with H5N1 highly pathogenic avian influenza virus
Misako Nakayama; Yasushi Itoh; Shintaro Shichinohe; Rumi Nakabayashi; Hirohito Ishigaki; Yoshihiro Sakoda; Quynh Mai Le; Yoshihiro Kawaoka; Hiroshi Kida; Kazumasa Ogasawara
VACCINE, Feb. 2017, Refereed, Not invited

Vaccination against H9N2 avian influenza virus reduces bronchus-associated lymphoid tissue formation in cynomolgus macaques after intranasal virus challenge infection
Misako Nakayama; Hiroichi Ozaki; Yasushi Itoh; Kosuke Soda; Hirohito Ishigaki; Masatoshi Okamatsu; Yoshihiro Sakoda; Chun-Ho Park; Hideaki Tsuchiya; Hiroshi Kida; Kazumasa Ogasawara
PATHOLOGY INTERNATIONAL, Dec. 2016, Refereed, Not invited

Sensitization with vaccinia virus encoding H5N1 hemagglutinin restores immune potential against H5N1 influenza virus
Fumihiko Yasui; Yasushi Itoh; Ai Ikejiri; Masahiro Kitabatake; Nobuo Sakaguchi; Keisuke Munekata; Shintaro Shichinohe; Yukiko Hayashi; Hirohito Ishigaki; Misako Nakayama; Yoshihiro Sakoda; Hiroshi Kida; Kazumasa Ogasawara; Michinori Kohara
SCIENTIFIC REPORTS, Nov. 2016, Refereed, Not invited

Surgical technique for allogeneic uterus transplantation in macaques
Hideaki Obara; Iori Kisu; Yojiro Kato; Yohei Yamada; Kentaro Matsubara; Katsura Emoto; Masataka Adachi; Yusuke Matoba; Kiyoko Umene; Yuya Nogami; Kouji Banno; Hideaki Tsuchiya; Iori Itagaki; Ikuo Kawamoto; Takahiro Nakagawa; Hirohito Ishigaki; Yasushi Itoh; Kazumasa Ogasawara; Yoko Saiki; Shin-ichi Sato; Kenshi Nakagawa; Takashi Shiina; Daisuke Aoki; Yuko Kitagawa
SCIENTIFIC REPORTS, Oct. 2016, Refereed, Not invited

Clinical Phenotype and Segregation of Mitochondrial 3243A > G Mutation in 2 Pairs of Monozygotic Twins
Kengo Maeda; Hiromichi Kawai; Mitsuru Sanada; Tomoya Terashima; Nobuhiro Ogawa; Ryo Idehara; Tetsuya Makiishi; Hitoshi Yasuda; Shun-ichi Sato; Ken-ichi Hoshi; Hiroyuki Yahikozawa; Katsuji Nishi; Yasushi Itoh; Kazumasa Ogasawara; Kazuo Tomita; Hiroko P. Indo; Hideyuki J. Majima
JAMA NEUROLOGY, Aug. 2016, Refereed, Not invited

Comparison of pathogenicities of H7 avian influenza viruses via intranasal and conjunctival inoculation in cynomolgus macaques
Shintaro Shichinohe; Yasushi Itoh; Misako Nakayama; Hiroichi Ozaki; Kosuke Soda; Hirohito Ishigaki; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida; Kazumasa Ogasawara
VIROLOGY, Jun. 2016, Refereed, Not invited

Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body
Yasunari Seita; Tomoyuki Tsukiyama; Chizuru Iwatani; Hideaki Tsuchiya; Jun Matsushita; Takuya Azami; Junko Okahara; Shinichiro Nakamura; Yoshitaka Hayashi; Seiji Hitoshi; Yasushi Itoh; Takeshi Imamura; Masaki Nishimura; Ikuo Tooyama; Hiroyuki Miyoshi; Mitinori Saitou; Kazumasa Ogasawara; Erika Sasaki; Masatsugu Ema
SCIENTIFIC REPORTS, Apr. 2016, Refereed, Not invited

Translational research on influenza virus infection using a nonhuman primate model
Yasushi Itoh
PATHOLOGY INTERNATIONAL, Mar. 2016, Refereed, Invited

Discovery of novel MHC-class I alleles and haplotypes in Filipino cynomolgus macaques (Macaca fascicularis) by pyrosequencing and Sanger sequencing
Takashi Shiina; Yukiho Yamada; Alice Aarnink; Shingo Suzuki; Anri Masuya; Sayaka Ito; Daisuke Ido; Hisashi Yamanaka; Chizuru Iwatani; Hideaki Tsuchiya; Hirohito Ishigaki; Yasushi Itoh; Kazumasa Ogasawara; Jerzy K. Kulski; Antoine Blancher
IMMUNOGENETICS, Oct. 2015, Refereed, Not invited

Emergence of H7N9 Influenza A Virus Resistant to Neuraminidase Inhibitors in Nonhuman Primates
Yasushi Itoh; Shintaro Shichinohe; Misako Nakayama; Manabu Igarashi; Akihiro Ishii; Hirohito Ishigaki; Hideaki Ishida; Naoko Kitagawa; Takako Sasamura; Masanori Shiohara; Michiko Doi; Hideaki Tsuchiya; Shinichiro Nakamura; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida; Kazumasa Ogasawara
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Aug. 2015, Refereed, Not invited

The SKINT1-Like Gene Is Inactivated in Hominoids But Not in All Primate Species: Implications for the Origin of Dendritic Epidermal T Cells
Rania Hassan Mohamed; Yoichi Sutoh; Yasushi Itoh; Noriyuki Otsuka; Yukiko Miyatake; Kazumasa Ogasawara; Masanori Kasahara
PLOS ONE, Apr. 2015, Refereed, Not invited

Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in dendritic cell-based vaccine
Yasuhiko Ohshio; Koji Teramoto; Jun Hanaoka; Noriaki Tezuka; Yasushi Itoh; Tohru Asai; Yataro Daigo; Kazumasa Ogasawara
CANCER SCIENCE, Feb. 2015, Refereed, Not invited

高病原性H5N1鳥インフルエンザウイルスに感染したカニクイザルの宿主応答
村本 裕紀子; Shoemaker Jason; Le Thi Quynh Mai; 伊藤 靖; 田村 大輔; 坂井 優子[田川]; 今井 博貴; 岡本 貴世子; 石垣 宏仁; 小笠原 一誠; 北野 宏明; 河岡 義裕
日本獣医学会学術集会講演要旨集, Aug. 2014

Disease Severity Is Associated with Differential Gene Expression at the Early and Late Phases of Infection in Nonhuman Primates Infected with Different H5N1 Highly Pathogenic Avian Influenza Viruses
Yukiko Muramoto; Jason E. Shoemaker; Mai Quynh Le; Yasushi Itoh; Daisuke Tamura; Yuko Sakai-Tagawa; Hirotaka Imai; Ryuta Uraki; Ryo Takano; Eiryo Kawakami; Mutsumi Ito; Kiyoko Okamoto; Hirohito Ishigaki; Hitomi Mimuro; Chihiro Sasakawa; Yukiko Matsuoka; Takeshi Noda; Satoshi Fukuyama; Kazumasa Ogasawara; Hiroaki Kitano; Yoshihiro Kawaoka
JOURNAL OF VIROLOGY, Aug. 2014, Refereed, Not invited

Efficacy of Repeated Intravenous Administration of Peramivir against Highly Pathogenic Avian Influenza A (H5N1) Virus in Cynomolgus Macaques
Mitsutaka Kitano; Yasushi Itoh; Hirohito Ishigaki; Misako Nakayama; Hideaki Ishida; Van Loi Pham; Masahiko Arikata; Shintaro Shichinohe; Hideaki Tsuchiya; Naoko Kitagawa; Masanori Kobayashi; Ryu Yoshida; Akihiko Sato; Quynh Mai Le; Yoshihiro Kawaoka; Kazumasa Ogasawara
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Aug. 2014, Refereed, Not invited

Protective Efficacy of Passive Immunization with Monoclonal Antibodies in Animal Models of H5N1 Highly Pathogenic Avian Influenza Virus Infection
Yasushi Itoh; Reiko Yoshida; Shintaro Shichinohe; Megumi Higuchi; Hirohito Ishigaki; Misako Nakayama; Van Loi Pham; Hideaki Ishida; Mitsutaka Kitano; Masahiko Arikata; Naoko Kitagawa; Yachiyo Mitsuishi; Kazumasa Ogasawara; Hideaki Tsuchiya; Takahiro Hiono; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida; Mutsumi Ito; Le Quynh Mai; Yoshihiro Kawaoka; Hiroko Miyamoto; Mari Ishijima; Manabu Igarashi; Yasuhiko Suzuki; Ayato Takada
PLOS PATHOGENS, Jun. 2014, Refereed, Not invited

Protection against H5N1 Highly Pathogenic Avian and Pandemic (H1N1) 2009 Influenza Virus Infection in Cynomolgus Monkeys by an Inactivated H5N1 Whole Particle Vaccine
Misako Nakayama; Shintaro Shichinohe; Yasushi Itoh; Hirohito Ishigaki; Mitsutaka Kitano; Masahiko Arikata; Van Loi Pham; Hideaki Ishida; Naoko Kitagawa; Masatoshi Okamatsu; Yoshihiro Sakoda; Takaya Ichikawa; Hideaki Tsuchiya; Shinichiro Nakamura; Quynh Mai Le; Mutsumi Ito; Yoshihiro Kawaoka; Hiroshi Kida; Kazumasa Ogasawara
PLOS ONE, Dec. 2013, Refereed, Not invited

Pathogenicity of Pandemic H1N1 Influenza A Virus in Immunocompromised Cynomolgus Macaques
Van Loi Pham; Misako Nakayama; Yasushi Itoh; Hirohito Ishigaki; Mitsutaka Kitano; Masahiko Arikata; Hideaki Ishida; Naoko Kitagawa; Shintaro Shichinohe; Masatoshi Okamatsu; Yoshihiro Sakoda; Hideaki Tsuchiya; Shinichiro Nakamura; Hiroshi Kida; Kazumasa Ogasawara
PLOS ONE, Sep. 2013, Refereed, Not invited

Efficacy of Repeated Intravenous Injection of Peramivir against Influenza A (H1N1) 2009 Virus Infection in Immunosuppressed Mice
Mitsutaka Kitano; Makoto Kodama; Yasushi Itoh; Takushi Kanazu; Masanori Kobayashi; Ryu Yoshida; Akihiko Sato
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, May 2013, Refereed, Not invited

Memory Immune Responses against Pandemic (H1N1) 2009 Influenza Virus Induced by a Whole Particle Vaccine in Cynomolgus Monkeys Carrying Mafa-A1*052:02
Masahiko Arikata; Yasushi Itoh; Masatoshi Okamatsu; Toshinaga Maeda; Takashi Shiina; Keiko Tanaka; Shingo Suzuki; Misako Nakayama; Yoshihiro Sakoda; Hirohito Ishigaki; Ayato Takada; Hideaki Ishida; Kosuke Soda; Van Loi Pham; Hideaki Tsuchiya; Shinichiro Nakamura; Ryuzo Torii; Takeshi Shimizu; Hidetoshi Inoko; Iwao Ohkubo; Hiroshi Kida; Kazumasa Ogasawara
PLOS ONE, May 2012, Refereed, Not invited, Corresponding

Efficacy of Single Intravenous Injection of Peramivir against Influenza B Virus Infection in Ferrets and Cynomolgus Macaques
Mitsutaka Kitano; Yasushi Itoh; Makoto Kodama; Hirohito Ishigaki; Misako Nakayama; Hideaki Ishida; Kaoru Baba; Takahiro Noda; Kenji Sato; Yoichiro Nihashi; Takushi Kanazu; Ryu Yoshida; Ryuzo Torii; Akihiko Sato; Kazumasa Ogasawara
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Nov. 2011, Refereed, Not invited

Expression of megakaryocytic and myeloid markers in blasts of transient abnormal myelopoiesis in a stillbirth with Down syndrome: report of histopathological findings of an autopsy case
Hirohito Ishigaki; Jun Miyauchi; Akira Yokoe; Misako Nakayama; Takahide Yanagi; Takashi Taga; Shigeru Ohta; Yasushi Itoh; Kazumasa Ogasawara
HUMAN PATHOLOGY, Jan. 2011, Refereed, Not invited

Establishment of a cynomolgus macaque model of influenza B virus infection
Mitsutaka Kitano; Yasushi Itoh; Makoto Kodama; Hirohito Ishigaki; Misako Nakayama; Tomoya Nagata; Hideaki Ishida; Hideaki Tsuchiya; Ryuzo Toni; Keiko Baba; Ryu Yoshida; Akihiko Sato; Kazumasa Ogasawara
VIROLOGY, Nov. 2010, Refereed, Not invited

Amelioration of pneumonia with Streptococcus pneumoniae infection by inoculation with a vaccine against highly pathogenic avian influenza virus in a non-human primate mixed infection model
Taichiro Miyake; Kosuke Soda; Yasushi Itoh; Yoshihiro Sakoda; Hirohito Ishigaki; Tomoya Nagata; Hideaki Ishida; Misako Nakayama; Hiroichi Ozaki; Hideaki Tsuchiya; Ryuzo Torii; Hiroshi Kida; Kazumasa Ogasawara
JOURNAL OF MEDICAL PRIMATOLOGY, Feb. 2010, Refereed, Not invited

Subcutaneous inoculation of a whole virus particle vaccine prepared from a non-pathogenic virus library induces protective immunity against H7N7 highly pathogenic avian influenza virus in cynomolgus macaques
Yasushi Itoh; Hiroichi Ozaki; Hirohito Ishigaki; Yoshihiro Sakoda; Tomoya Nagata; Kosuke Soda; Norikazu Isoda; Taichiro Miyake; Hideaki Ishida; Kiyoko Okamoto; Misako Nakayama; Hideaki Tsuchiya; Ryuzo Torii; Hiroshi Kida; Kazumasa Ogasawara
VACCINE, Jan. 2010, Refereed, Not invited

Intranasal administration of a live non-pathogenic avian H5N1 influenza virus from a virus library confers protective immunity against H5N1 highly pathogenic avian influenza virus infection in mice: Comparison of formulations and administration routes of vaccines
Yoshitaka Kashima; Mizuho Ikeda; Yasushi Itoh; Yoshihiro Sakoda; Tomoya Nagata; Taichiro Miyake; Kosuke Soda; Hiroichi Ozaki; Misako Nakayama; Hitomi Shibuya; Masatoshi Okamatsu; Hirohito Ishigaki; Hideaki Ishida; Toshihiro Sawai; Yoshihiro Kawaoka; Hiroshi Kida; Kazumasa Ogasawar
VACCINE, Dec. 2009, Refereed, Not invited

CRTAM Confers Late-Stage Activation of CD8(+) T Cells to Regulate Retention within Lymph Node
Arata Takeuchi; Yasushi Itoh; Akiko Takumi; Chitose Ishihara; Noriko Arase; Tadashi Yokosuka; Haruhiko Koseki; Sho Yamasaki; Yoshimi Takai; Jun Miyoshi; Kazumasa Ogasawara; Takashi Saito
JOURNAL OF IMMUNOLOGY, Oct. 2009, Refereed, Not invited

MHC class I A loci polymorphism and diversity in three Southeast Asian populations of cynomolgus macaque.
Yuki F Kita; Kazuyoshi Hosomichi; Sakae Kohara; Yasushi Itoh; Kazumasa Ogasawara; Hideaki Tsuchiya; Ryuzo Torii; Hidetoshi Inoko; Antoine Blancher; Jerzy K Kulski; Takashi Shiina
Immunogenetics, Sep. 2009, Refereed, Not invited

In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
Yasushi Itoh; Kyoko Shinya; Maki Kiso; Tokiko Watanabe; Yoshihiro Sakoda; Masato Hatta; Yukiko Muramoto; Daisuke Tamura; Yuko Sakai-Tagawa; Takeshi Noda; Saori Sakabe; Masaki Imai; Yasuko Hatta; Shinji Watanabe; Chengjun Li; Shinya Yamada; Ken Fujii; Shin Murakami; Hirotaka Imai; Satoshi Kakugawa; Mutsumi Ito; Ryo Takano; Kiyoko Iwatsuki-Horimoto; Masayuki Shimojima; Taisuke Horimoto; Hideo Goto; Kei Takahashi; Akiko Makino; Hirohito Ishigaki; Misako Nakayama; Masatoshi Okamatsu; Kazuo Takahashi; David Warshauer; Peter A. Shult; Reiko Saito; Hiroshi Suzuki; Yousuke Furuta; Makoto Yamashita; Keiko Mitamura; Kunio Nakano; Morio Nakamura; Rebecca Brockman-Schneider; Hiroshi Mitamura; Masahiko Yamazaki; Norio Sugaya; M. Suresh; Makoto Ozawa; Gabriele Neumann; James Gern; Hiroshi Kida; Kazumasa Ogasawara; Yoshihiro Kawaoka
NATURE, Aug. 2009, Refereed, Not invited

Lipoid pneumonia with chronic myelomonocytic leukemia
Yasushi Itoh; Hidekazu Segawa; Katsuyuki Kito; Keiko Hodohara; Hirohito Ishigaki; Hiroyuki Sugihara; Yoshihide Fujiyama; Kazumasa Ogasawara
PATHOLOGY RESEARCH AND PRACTICE, 2009, Refereed, Not invited

Induction of cytotoxic T-lymphocyte and antibody responses against highly pathogenic avian influenza virus infection in mice by inoculation of apathogenic H5N1 influenza virus particles inactivated with formalin
Toshihiro Sawai; Yasushi Itoh; Hiroichi Ozaki; Norikazu Isoda; Kiyoko Okamoto; Yoshitaka Kashima; Yoshihiro Kawaoka; Yoshihiro Takeuchi; Hiroshi Kida; Kazumasa Ogasawara
IMMUNOLOGY, Jun. 2008, Refereed, Not invited

A vaccine prepared from a non-pathogenic H5N1 avian influenza virus strain confers protective immunity against highly pathogenic avian influenza virus infection in cynomolgus macaques
Yasushi Itoh; Hiroichi Ozaki; Hideaki Tsuchiya; Kiyoko Okamoto; Ryuzo Torii; Yoshihiro Sakoda; Yoshihiro Kawaoka; Kazumasa Ogasawara; Hiroshi Kida
VACCINE, Jan. 2008, Refereed, Not invited

Analysis of splenic Gr-1(int) immature myeloid cells in tumor-bearing mice
Yoshiko Yamamoto; Hirohito Ishigaki; Hideaki Ishida; Yasushi Itoh; Yoichi Noda; Kazumasa Ogasawara
MICROBIOLOGY AND IMMUNOLOGY, Jan. 2008, Refereed, Not invited

Peptides coupled to the surface of a kind of liposome protect infection of influenza viruses
Tomoya Nagata; Toshiaki Toyota; Hirohito Ishigaki; Toru Ichihashi; Kiichi Kajino; Yoshitaka Kashima; Yasushi Itoh; Masahito Mori; Hiroshi Oda; Hiroyuki Yamamura; Maiko Taneichi; Tetsuya Uchida; Kazumasa Ogasawara
VACCINE, Jun. 2007, Refereed, Not invited

Successful tumor eradication was achieved by collaboration of augmented cytotoxic activity and anti-angiogenic effects following therapeutic vaccines containing helper-activating analog-loaded dendritic cells and tumor antigen DNA
Koji Teramoto; Keiichi Kontani; Takuya Fujita; Yoshitomo Ozaki; Satoru Sawai; Noriaki Tezuka; Shozo Fujino; Yasushi Itoh; Osamu Taguchi; Reiji Kannagi; Kazumasa Ogasawara
CANCER IMMUNOLOGY IMMUNOTHERAPY, Mar. 2007, Refereed, Not invited

Preparation and functional analysis of tumor-infiltrating stroma cells using bone marrow chimera mice
Hirohito Ishigaki; Yoshiko Yamamoto; Hideaki Ishida; Klichi Kajino; Yasushi Itoh; Yoshihide Fujiyama; Kazumasa Ogasawara
MICROBIOLOGY AND IMMUNOLOGY, 2006, Refereed, Not invited

Decreased CD4 expression by polarized T helper 2 cells contributes to suboptimal TCR-induced phosphorylation and reduced Ca2+ signaling
Y Itoh; Z Wang; H Ishida; K Eichelberg; N Fujimoto; J Makino; K Ogasawara; RN Germain
EUROPEAN JOURNAL OF IMMUNOLOGY, Nov. 2005, Refereed, Not invited

Deoxyribonucleic acid (DNA) encoding a pan-major histocompatibility complex class II peptide analogue augmented antigen-specific cellular immunity and suppressive effects on tumor growth elicited by DNA vaccine immunotherapy
K Teramoto; K Kontani; Y Ozaki; S Sawai; N Tezuka; T Nagata; S Fujino; Y Itoh; O Taguchi; Y Koide; T Asai; Ohkubo, I; K Ogasawara
CANCER RESEARCH, Nov. 2003, Refereed, Not invited

Quantities of interleukin-12p40 in mature CD8 alpha negative dendritic cells correlate with strength of TCR signal and determine Th cell development
N Fujimoto; H Ishida; Nakamura, I; K Ogasawara; Y Itoh
MICROBIOLOGY AND IMMUNOLOGY, 2003, Not refereed, Not invited

Novel vaccination protocol consisting of injecting MUC1 DNA and nonprimed dendritic cells at the same region greatly enhanced MUC1-specific antitumor immunity in a murine model
K Kontani; O Taguchi; Y Ozaki; J Hanaoka; N Tezuka; S Sawai; S Inoue; S Fujino; T Maeda; Y Itoh; K Ogasawara; H Sato; Ohkubo, I; T Kudo
CANCER GENE THERAPY, Apr. 2002, Refereed, Not invited

インフルエンザに対するペプチドワクチンの開発
成人病と生活習慣病, 2002, Not refereed, Not invited

II. T 細胞 ２． Th1/Th2分化とpartial agonist
Annual Review 免疫2003（株)中外医学社, 2002, Not refereed, Not invited

Genomic DNA released by dying cells induces the maturation of APCs
KJ Ishii; K Suzuki; C Coban; F Takeshita; Y Itoh; H Matoba; LD Kohn; DM Klinman
JOURNAL OF IMMUNOLOGY, Sep. 2001, Refereed, Not invited

IL-12 induction by a Th1-inducing adjuvant in vivo: Dendritic cell subsets and regulation by IL-10
LY Huang; CR Sousa; Y Itoh; J Inman; DE Scott
JOURNAL OF IMMUNOLOGY, Aug. 2001, Refereed, Not invited

パーシャルシグナルとTh1/Th2細胞の分化
臨床免疫, 2001, Not refereed, Not invited

Serial TCR engagement and down-modulation by peptide : MHC molecule ligands: Relationship to the quality of individual TCR signaling events
Y Itoh; B Hemmer; R Martin; RN Germain
JOURNAL OF IMMUNOLOGY, Feb. 1999, Refereed, Not invited

Intranasal immunization with cytotoxic T-lymphocyte epitope peptide and mucosal adjuvant cholera toxin: Selective augmentation of peptide-presenting dendritic cells in nasal mucosa-associated lymphoid tissue
A Porgador; HF Staats; Y Itoh; BL Kelsall
INFECTION AND IMMUNITY, Dec. 1998, Refereed, Not invited

An increase in basal glucocorticoid concentration with age induces suppressor macrophages with high-density Fc gamma RII/III
T Kizaki; T Ookawara; S Oh-Ishi; Y Itoh; K Iwabuchi; K Onoe; NK Day; RA Good; H Ohno
IMMUNOLOGY, Mar. 1998, Refereed, Not invited

Interaction of pigeon cytochrome c-(43-58) peptide analogs with either T cell antigen receptor or I-Ab molecule
Y Itoh; K Kajino; K Ogasawara; A Takahashi; KI Namba; Negishi, I; N Matsuki; K Iwabuchi; M Kakinuma; RA Good; K Onoe
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 1997, Refereed, Not invited

Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4(+) T cells
Y Itoh; RN Germain
JOURNAL OF EXPERIMENTAL MEDICINE, Aug. 1997, Refereed, Not invited

Detachment activity but not cytotoxicity induced in a T-cell clone following antigen presentation in the presence of thymic epithelial cells
R Kaneda; M Kasai; Y Itoh; K Iwabuchi; K Onoe
MICROBIOLOGY AND IMMUNOLOGY, 1997, Refereed, Not invited

Determination of the allele-specific antigen-binding site on I-A(kappa) and I-A(b) molecules
Y Itoh; K Kajino; K Ogasawara; M Kotoh; K Namba; K Takami; K Iwabuchi; NS Braunstein; K Onoe
EUROPEAN JOURNAL OF IMMUNOLOGY, Jun. 1996, Refereed, Not invited

A promiscuous T cell hybridoma restricted to various I-A molecules
M Katoh; Y Itoh; K Ogasawara; K Kajino; H Nishihori; A Takahashi; N Matsuki; K Iwabuchi; TO Yoshida; RA Good; K Onoe
EUROPEAN JOURNAL OF IMMUNOLOGY, May 1996, Refereed, Not invited

TISSUE DISTRIBUTION OF ISOFORMS OF TYPE-1 PROTEIN PHOSPHATASE PP1 IN MOUSE-TISSUES AND ITS DIABETIC ALTERATIONS
N TAKIZAWA; Y MIZUNO; Y ITO; K KIKUCHI
JOURNAL OF BIOCHEMISTRY, Aug. 1994, Refereed, Not invited

ANALYSIS OF EPITOPIC RESIDUES INTRODUCED INTO THE HYBRID PEPTIDE VACCINES PREPARED ACCORDING TO THE CASSETTE THEORY
H NARUSE; K OGASAWARA; K TAKAMI; K KAJINO; T GOTOHDA; Y ITOH; T MIYAZAKI; RA GOOD; K ONOE
VACCINE, Jul. 1994, Refereed, Not invited

DETERMINATION OF AMINO-ACIDS ON AGRETOPES OF PIGEON CYTOCHROME C-RELATED PEPTIDES SPECIFICALLY BOUND TO I-A ALLELIC PRODUCTS
Y ITOH; K OGASAWARA; K TAKAMI; T GOTOHDA; H NARUSE; RA GOOD; K ONOE
EUROPEAN JOURNAL OF IMMUNOLOGY, Jan. 1994, Refereed, Not invited

DETERMINATION OF THE AGRETOPIC RESIDUES OF A PEPTIDE CO-RESTRICTED TO DIFFERENT CLASS-II ISOTYPES, I-A(U) AND I-E(U), AND ITS APPLICATION FOR PREPARATION OF A SYNTHETIC PEPTIDE VACCINE AGAINST INFLUENZA-VIRUS A/AICHI/2/68
K TAKAMI; K OGASAWARA; Y ITOH; K KAJINO; H NARUSE; K ONOE
MICROBIOLOGY AND IMMUNOLOGY, 1994, Refereed, Not invited

COMPARATIVE ANALYSES OF THYMOCYTE AND THYMIC LOW-DENSITY ADHERENT CELL FUNCTIONS
PP WAMBUA; K IWABUCHI; C IWABUCHI; K OGASAWARA; Y ITOH; H ARASE; M KAJIWARA; T GOTOHDA; K KAJINO; RA GOOD; K ONOE
MICROBIOLOGY AND IMMUNOLOGY, 1994, Refereed, Not invited

FINE ANALYSIS OF RECOGNITION SITES OF MONOCLONAL-ANTIBODIES, 1B7 AND 1E4, USING L-CELL TRANSFECTANTS OF RECOMBINANT MOUSE MHC CLASS-II GENES
Y ITOH; K OGASAWARA; K ONOE
EUROPEAN JOURNAL OF IMMUNOGENETICS, Feb. 1993, Refereed, Not invited

FINE ANALYSIS OF RECOGNITION SITES OF MONOCLONAL ANTIBODIES, 1B7 AND 1E4, USING L CELL TRANSFECTANTS OF RECOMBINANT MOUSE MHC CLASS II GENES
Y. Itoh; K. Ogasawara; K. Onoé
International Journal of Immunogenetics, 1993, Refereed, Not invited

A STRATEGY FOR MAKING SYNTHETIC PEPTIDE VACCINES
K OGASAWARA; H NARUSE; Y ITOH; T GOTOHDA; J ARIKAWA; H KIDA; RA GOOD; K ONOE
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 1992, Refereed, Not invited

A HOLE IN THE T-CELL REPERTOIRE SPECIFIC FOR A PIGEON CYTOCHROME-C RELATED PEPTIDE ASSOCIATED WITH AMINO-ACID SUBSTITUTIONS ON I-A(B) MOLECULES
Y ITOH; K OGASAWARA; T GOTOHDA; K TAKAMI; H NARUSE; K ONOE
INTERNATIONAL IMMUNOLOGY, Jul. 1992, Refereed, Not invited

GENERATION OF THE T-CELL REPERTOIRE CROSS-REACTIVE TO A SELF-PEPTIDE ANTIGEN INFLUENCED BY THE MHC CLASS-II MUTATION
K ONOE; T GOTOHDA; Y ITOH; K OGASAWARA
MOLECULAR APPROACHES TO THE STUDY AND TREATMENT OF HUMAN DISEASES, 1992, Refereed, Not invited

DEFICIENCY IN EARLY DEVELOPMENT OF THE THYMUS-DEPENDENT CELLS IN IRRADIATION CHIMERAS ATTRIBUTABLE TO RECIPIENTS ENVIRONMENT
C IWABUCHI; K IWABUCHI; S KOBAYASHI; K OGASAWARA; NEGISHI, I; B WANG; PP WAMBUA; H ARASE; N FUKUSHI; Y ITOH; T GOTOHDA; RA GOOD; K ONOE
JOURNAL OF IMMUNOLOGY, Jan. 1991, Refereed, Not invited

霊長類モデルを用いたワクチン有効性評価
伊藤靖
実験動物ニュース, Jul. 2024, Refereed, Invited

くも膜下出血におけるミトコンドリアフェリチンの局在と機能に関する検討
高畑翔吾; 加藤智子; 柳沢大治郎; 向所賢一; 伊藤靖; 遠山育夫
日本組織細胞化学会総会・学術集会講演プログラム・予稿集, 2023

Long-term efficacy of an inactivated whole particle H5N1 virus against H5N1 highly pathogenic avian influenza virus challenge in cynomolgus monkeys
M Nakayama; H Ishigaki; N Thanh Cong; S Suzuki; H Ishida; N Kitagawa; K Ogasawara; Y Itoh
European Respiratory Journal, 01 Dec. 2022, Refereed, Not invited

サルにおける嗅上皮から嗅神経を介したSARS-CoV-2の頭蓋内感染について
清水 志乃; 仲山 美沙子; 石垣 宏仁; Nguyen Thanh Cong; 北川 善紀; 伊藤 靖; 清水 猛史
日本鼻科学会会誌, Oct. 2022

An attenuated vaccinia vaccine encoding the SARS-CoV-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human ACE2 transgenic mice from SARS-CoV-2 and its variants
Hirohito Ishigaki; Fumihiko Yasui; Misako Nakayama; Akinori Endo; Naoki Yamamoto; Kenzaburo Yamaji; Cong Thanh Nguyen; Yoshinori Kitagawa; Takahiro Sanada; Tomoko Honda; Tsubasa Munakata; Masahiko Higa; Sakiko Toyama; Risa Kono; Asako Takagi; Yusuke Matsumoto; Kaori Hayashi; Masanori Shiohara; Koji Ishii; Yasushi Saeki; Yasushi Itoh; Michinori Kohara
bioRxiv, 13 Jun. 2022, Not refereed
Corresponding

サルにおける嗅上皮から嗅神経を介したSARS-CoV-2の頭蓋内感染について
清水志乃; 仲山美沙子; 石垣宏仁; NGUYEN Thanh Cong; 北川善紀; 伊藤靖; 清水猛史
日本鼻科学会会誌(Web), 2022

高度弱毒化ワクシニアウイルスベクターDIsを用いたCOVID-19ワクチンの交差反応性と長期免疫持続効果の検討
安井文彦; 松本祐介; 石垣宏仁; 仲山美沙子; 山本直樹; 真田崇弘; 山地賢三郎; THANH Nguyen Cong; 本田智子; 北川善紀; 伊藤靖; 小原道法
日本ワクチン学会学術集会プログラム・抄録集, 2022

COVID-19ワクシニアウイルスベクターワクチンの開発
安井文彦; 伊藤靖; 山地賢三郎; 山本直樹; 松本祐介; 真田崇弘; 本田智子; 棟方翼; 石垣宏仁; 仲山美沙子; 高木朝子; 石井浩司; 小原道法
日本実験動物学会総会講演要旨集(Web), 2022

霊長類モデルを用いたインフルエンザとCOVID-19のワクチン開発
伊藤靖; 石垣宏仁; 仲山美沙子; NGUYEN Thanh Cong; 北川善紀; 安井文彦; 小原道法; 石井健; 新開大史; 迫田義博; 喜田宏
日本実験動物学会総会講演要旨集(Web), 2022

Optimization of an LNP-mRNA vaccine candidate targeting SARS-CoV-2 receptor-binding domain
Kouji Kobiyama; Masaki Imai; Nao Jounai; Misako Nakayama; Kou Hioki; Kiyoko Iwatsuki-Horimoto; Seiya Yamayoshi; Jun Tsuchida; Takako Niwa; Takashi Suzuki; Mutsumi Ito; Shinya Yamada; Tokiko Watanabe; Maki Kiso; Hideo Negishi; Burcu Temizoz; Hirohito Ishigaki; Yoshinori Kitagawa; Cong Thanh Nguyen; Yasushi Itoh; Fumihiko Takeshita; Yoshihiro Kawaoka; Ken J. Ishii
bioRxiv, 04 Mar. 2021, Not refereed
https://syndication.highwire.org/content/doi/10.1101/2021.03.04.433852

Targeted macrocycles hamper hemagglutinin adsorption and fusion, and have antiviral effects in murine and macaque models of influenza
齊藤誠; 伊藤靖; 安井文彦; 棟方翼; 山根大典; 小沢真; 山地賢三郎; 山本直樹; 本田智子; 真田崇弘; 小原恭子; 菅裕明; 小原道法
日本分子生物学会年会プログラム・要旨集(Web), 2021

カニクイザルで自然発症した子宮内膜症の2年間の腹腔鏡観察による評価
林香里; 仲山美沙子; 中村紳一郎; 辻俊一郎; 木村文則; 伊藤靖; 村上節
日本エンドメトリオーシス学会プログラム・抄録集, 2021

高度弱毒化ワクシニアウイルスDIsを用いたCOVID-19ワクチンの作出と変異株に対する防御効果の検討
安井文彦; 伊藤靖; 石垣宏仁; 仲山美沙子; 山本直樹; 山地賢三郎; CONG Thanh Nguyen; 遠藤彬則; 本田智子; 真田崇弘; 松本祐介; 棟方翼; 比嘉雅彦; 佐伯泰; 小原道法
日本ワクチン学会学術集会プログラム・抄録集, 2021

バイオマテリアルとしてのカニクイザル不死化Bリンパ球バンクの構築
守村敏史; 伊藤靖; 等誠司; 遠山育夫; 依馬正次
日本獣医学会学術集会講演要旨集, 2021

新型コロナウイルスに対する抗体療法について
竹下勝; 森山彩野; 福山英啓; 白水美香子; 石垣宏仁; 仲山美沙子; 伊藤靖; 佐谷秀行; 竹内勤
日本輸血細胞治療学会誌, 2021

霊長類モデルを用いた新型コロナウイルス研究
伊藤靖; 石垣宏仁; 仲山美沙子
日本実験動物学会総会講演要旨集(Web), 2021

Pathological analysis of cynomolgus macaques infected with SARS-CoV-2
石垣宏仁; 仲山美沙子; 伊藤靖
日本病理学会会誌, 2021

カニクイザルの腫瘍拒絶モデルにおける腫瘍浸潤T細胞からの腫瘍殺傷能をもつTCR遺伝子の単離
寺田晃士; 石垣宏仁; 近藤健太; 長嶋彩花; 里岡大樹; 永野誠治; 増田喬子; 川村晃久; 河本宏; 平田多佳子; 小笠原一誠; 伊藤靖; 縣保年
日本分子生物学会年会プログラム・要旨集(Web), 2020

カニクイザルを用いたH5N6亜型高病原性鳥インフルエンザウイルスによる重症肺炎の解析
伊藤 靖; Nguyen Thanh Cong; 鈴木 紗織; 石垣 宏仁; 仲山 美沙子; 小笠原 一誠
日本病理学会会誌, Apr. 2019, Not refereed, Not invited

プロトンポンプ阻害薬内服患者における胃底腺ポリープの組織学的特徴とポリープ増大因子の検討
福田 昌英; 石垣 宏仁; 松原 亜季子; 森谷 鈴子; 向所 賢一; 杉原 洋行; 伊藤 靖; 小笠原 一誠; 村上 和成; 九嶋 亮治
日本病理学会会誌, Apr. 2019, Not refereed, Not invited

H7N9亜型鳥インフルエンザウイルスのノイラミニダーゼ阻害薬耐性変異とその病原性
鈴木 紗織; 七戸 新太郎; 伊藤 靖; 小笠原 一誠
日本獣医学会学術集会講演要旨集, Aug. 2018, Not refereed, Not invited

霊長類を用いた疾患モデルにおける炎症反応の解析
伊藤靖; 石垣宏仁; 仲山美沙子; 小笠原一誠
日本病理学会会誌, 26 Apr. 2018, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201802211270364717

抗GRP94抗体による癌の免疫監視機構
石垣宏仁; 仲山美沙子; 伊藤靖; 小笠原一誠
日本病理学会会誌, 26 Apr. 2018, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201802273648056233

正所性膀胱癌モデルラットを用いたBCG膀胱注入療法による全身性免疫応答および制御性T細胞の検討
村井亮介; 影山進; 伊藤靖; 石垣宏仁; 寺本和雄; 吉田哲也; 富田圭司; 小林憲市; 和田晃典; 永澤誠之; 窪田成寿; 小笠原一誠; 河内明宏
泌尿器外科, 15 Apr. 2018, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201802257986737868

正所性膀胱癌モデルラットを用いたBCG膀胱注入療法による免疫抑制性細胞の検討
村井 亮介; 影山 進; 伊藤 靖; 石垣 宏仁; 寺本 和雄; 吉田 哲也; 富田 圭司; 小林 憲市; 和田 晃典; 永澤 誠之; 窪田 成寿; 小笠原 一誠; 河内 明宏
日本泌尿器科学会総会, Apr. 2018, Not refereed, Not invited

正所性膀胱癌モデルラットを用いたBCG膀胱注入療法による免疫抑制性細胞の検討
村井亮介; 影山進; 伊藤靖; 石垣宏仁; 寺本和雄; 吉田哲也; 富田圭司; 小林憲市; 和田晃典; 永澤誠之; 窪田成寿; 小笠原一誠; 河内明宏
日本泌尿器科学会総会(Web), 2018, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201802282732294673

不活化インフルエンザウイルス全粒子ワクチンの非臨床試験
新開大史; 新開大史; 野村直樹; 関屋俊輝; 関屋俊輝; 大野円実; 笹田万友美; 大東卓史; 鈴木紗織; 石垣宏仁; 伊藤靖; 小笠原一誠; 小笠原一誠; 喜田宏; 喜田宏; 喜田宏
日本ワクチン学会学術集会プログラム・抄録集, 2018, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201802221381363186

カニクイザルでのH7N9鳥インフルエンザHAタンパク質発現組換えワクシニアワクチンの発症防御効果の検討
山地賢三郎; 安井文彦; 伊藤靖; 鈴木紗織; 本田智子; 山本直樹; 真田崇弘; 石垣宏仁; 石井孝司; 小笠原一誠; 小原道法
日本ワクチン学会学術集会プログラム・抄録集, 2018, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201802277121855907

サルモデルを用いた季節性インフルエンザに対する不活化全粒子ワクチンの有効性評価
伊藤靖; 鈴木紗織; 石垣宏仁; 仲山美沙子; 新開大史; 新開大史; 大東卓史; 野村直樹; 喜田宏; 喜田宏; 喜田宏; 小笠原一誠; 小笠原一誠
日本ワクチン学会学術集会プログラム・抄録集, 2018, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201802280513412951

LAP陽性T細胞吸着材カラムの癌治療への応用
寺本和雄; 遠藤善裕; 上田祐二; 村井亮介; 伊藤靖; 小笠原一誠
人工臓器(日本人工臓器学会), 31 Aug. 2017, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201702215987940165

人工腎臓治療の新時代 LAP陽性T細胞吸着材カラムの癌治療への応用
寺本 和雄; 遠藤 善裕; 上田 祐二; 村井 亮介; 伊藤 靖; 小笠原 一誠
人工臓器, Aug. 2017, Not refereed, Not invited

ノイラミニダーゼ阻害薬耐性H7N9亜型鳥インフルエンザウイルスの薬剤非投与カニクイザルにおける病原性評価
鈴木 紗織; 七戸 新太郎; 伊藤 靖; 小笠原 一誠
日本獣医学会学術集会講演要旨集, Aug. 2017, Not refereed, Not invited

Pathogenicity of avian influenza virus under an immunosuppressive condition in a cynomolgus monkey model
伊藤 靖; 小笠原 一誠
臨床免疫・アレルギー科 = Clinical immunology & allergology, Jul. 2017

筋層非浸潤膀胱癌に対するBCG膀胱注入療法における制御性T細胞の検討
村井亮介; 影山進; 仲山美沙子; 石垣宏仁; 寺本和雄; 伊藤靖; 富田圭司; 小林憲市; 和田晃典; 永澤誠之; 小笠原一誠; 河内明宏
泌尿器外科, 15 Apr. 2017, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201702233291557994

免疫低下霊長類モデルにおける高病原性鳥インフルエンザウイルスによる肺炎(Viral pneumonia caused by H5N1 highly pathogenic avian influenza virus in immunosuppressed macaques)
伊藤 靖; 仲山 美沙子; 石垣 宏仁; 小笠原 一誠
日本病理学会会誌, Mar. 2017, Not refereed, Not invited

膀胱癌における制御性T細胞
村井亮介; 影山進; 富田圭司; 小林憲市; 河内明宏; 伊藤靖; 仲山美沙子; 石垣宏仁; 寺本和雄; 小笠原一誠
日本泌尿器科学会中部総会プログラム・抄録集, 2017, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201802248362757063

癌の免疫監視において、自己抗体を含む液性免疫も重要である
石垣 宏仁; 仲山 美沙子; 伊藤 靖; 小笠原 一誠
日本癌学会総会記事, Oct. 2016, Not refereed, Not invited

カニクイザルを用いたインフルエンザワクチンによる免疫記憶に及ぼす免疫抑制剤の影響の解析
伊藤靖; 仲山美沙子; 石垣宏仁; 小笠原一誠
日本病理学会会誌, 12 Apr. 2016, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201602284552320276

正常カニクイザルの全身臓器における炎症性および抑制性マクロファージの分布
高石亮太; 仲山美沙子; 石垣宏仁; 伊藤靖; 小笠原一誠
日本病理学会会誌, 12 Apr. 2016, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201602206744160921

癌拒絶カニクイザルの癌に対する免疫応答の解析
石垣宏仁; 仲山美沙子; 伊藤靖; 小笠原一誠
日本病理学会会誌, 12 Apr. 2016, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201602225540172720

自然発症サル子宮内膜症モデルの組織学的解析
仲山美沙子; 中村紳一朗; 土屋英明; 石垣宏仁; 伊藤靖; 森崇英; 小笠原一誠
日本病理学会会誌, 12 Apr. 2016, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201602280768265940

筋層非浸潤膀胱癌における制御性T細胞の病理組織学的検討
村井亮介; 仲山美沙子; 影山進; 石垣宏仁; 寺本和雄; 伊藤靖; 富田圭司; 小林憲市; 和田晃典; 永澤誠之; 窪田成寿; 小笠原一誠; 河内明宏
日本癌治療学会学術集会(Web), 2016, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201602269354375874

大規模DNAタイピングによるMHC統御カニクイザルの検出
椎名 隆; 山田 幸穂; 鈴木 進悟; 桝屋 安里; 伊藤 さやか; 岩谷 千鶴; 土屋 英明; 伊藤 靖; 山中 久; 中川 賢司; 小笠原 一誠
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015, Not refereed, Not invited

癌抗原GRP94とGRP78は癌抑制遺伝子p53とRBの不活性化により誘導される
石垣 宏仁; 仲山 美沙子; 伊藤 靖; 小笠原 一誠
日本癌学会総会記事, Oct. 2015, Not refereed, Not invited

非ヒト霊長類動物における脳死ドナーを想定した子宮移植の臓器灌流手技および同種移植の経験
木須 伊織; 加藤 容二郎; 山田 洋平; 梅根 紀代子; 安達 将隆; 松原 健太郎; 尾原 秀明; 土屋 英明; 板垣 伊織; 河本 育士; 中川 孝博; 石垣 宏仁; 伊藤 靖; 小笠原 一誠; 佐藤 伸一; 中川 賢司; 椎名 隆; 阪埜 浩司; 青木 大輔
日本婦人科腫瘍学会雑誌, Jun. 2015, Not refereed, Not invited

全粒子ワクチンは複数のクレードのH5N1高病原性鳥インフルエンザウイルスに対する記憶免疫反応を誘導する
仲山 美沙子; 七戸 新太郎; 伊藤 靖; 石垣 宏仁; 北野 光崇; 有方 雅彦; Pham Van Loi; 石田 英晃; 北川 直子; 小笠原 一誠; 土屋 英明; 中村 紳一朗; 岡松 正敏; 迫田 義博; 市川 貴也; 喜田 宏; Le Quynh Mai; 伊藤 睦美; 河岡 義裕
滋賀医学, Mar. 2015, Not refereed, Not invited

カニクイザルを用いたライブラリー由来全粒子不活化ワクチンのH7N9亜型インフルエンザウイルスに対する有効性
伊藤靖; 七戸新太郎; 仲山美沙子; 石垣宏仁; 岡松正敏; 迫田義博; 喜田宏; 小笠原一誠
日本ワクチン学会学術集会プログラム・抄録集, 2015

単球上のLatency associated peptideの発現比率に基づくサル生体内免疫反応の違い
仲山美沙子; 伊藤靖; 石垣宏仁; 小笠原一誠
日本病理学会会誌, 2015

霊長類モデルを用いた不活化H5N1全粒子ワクチン経鼻接種によって誘導される免疫反応の組織学的解析
中林瑠美; 仲山美沙子; 伊藤靖; 石垣宏仁; 小笠原一誠
日本病理学会会誌, 2015

癌細胞拒絶カニクイザル血漿中に含まれる抗体の解析
石垣宏仁; 仲山美沙子; 伊藤靖; 小笠原一誠
日本病理学会会誌, 2015

カニクイザルのMHC遺伝子のNGSベースDNA型分析方法の開発(Development of a NGS based DNA typing method of MHC genes for Cynomolgus Macaque)
Yamada Yukiho; Tanaka Keiko; Iwatani Chizuru; Tsuchiya Hideaki; Itoh Yasushi; Yoneda Kimio; Yamanaka Hisashi; Nakagawa Hiroshi; Ota Masao; Inoko Hidetoshi; Ogasawara Kazumasa; Shiina Takashi
Experimental Animals, Dec. 2014, Not refereed, Not invited

H5N1高病原性鳥インフルエンザウイルスがブタに感染するとSAα2,6Galレセプターに結合するウイルスが選択されるか?
七戸新太郎; 迫田義博; 西達也; 日尾野隆大; 岡松正敏; 伊藤靖; 小笠原一誠; 喜田宏
日本ウイルス学会学術集会プログラム・抄録集, 31 Oct. 2014, Not refereed, Not invited

H5N1インフルエンザウイルスに対する中和抗体を用いた受動免疫の感染防御効果
吉田玲子; 伊藤靖; 七戸新太郎; 小笠原一誠; 日尾野隆大; 岡松正敏; 迫田義博; 喜田宏; LE Mai Quynh; 河岡義裕; 五十嵐学; 鈴木定彦; 高田礼人
日本ウイルス学会学術集会プログラム・抄録集, 31 Oct. 2014, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201402252007522240

LAP陽性制御性T細胞に対する選択吸着カラムの癌治療への応用
寺本和雄; 遠藤善裕; 伊藤靖; 小笠原一誠
日本透析医学会雑誌, 28 May 2014, Not refereed, Not invited
http://jglobal.jst.go.jp/public/201402276239466106

胸腺癌のマーカー分子を発現した胸腺腫type B3の1例
NAKAYAMA MISAKO; OYANAGI HIROKI; TAKEMURA SHIZUKI; UMANO SHINJI; HAYASHI YUJI; YOSHIDA AKIKO; ISHIGAKI HIROHITO; ITO YASUSHI; OGASAWARA KAZUMASA; SUGIHARA HIROYUKI
診断病理, 30 Apr. 2014, Not refereed, Not invited

免疫低下状態のカニクイザルにおけるH1N1亜型インフルエンザウイルスの病原性の解析
伊藤靖; LOI Pham Van; 仲山美沙子; 石垣宏仁; 有方雅彦; 石田英晃; 北川直子; 小笠原一誠; 七戸新太郎; 岡松正敏; 迫田義博; 喜田宏; 喜田宏
滋賀医学, 20 Mar. 2014, Not refereed, Not invited

Efficacy of a whole particle vaccine against H7N9 influenza virus in cynomolgus macaques
Proceedings of the Japanese Society for Immunology, 2014, Not refereed, Not invited

カニクイザルにおける2013年H7N9亜型インフルエンザウイルスに対するワクチンとNA阻害薬の効果
日本病理学会会誌, 2014, Not refereed, Not invited

霊長類モデルを用いたインフルエンザウイルスの病原性の解明と予防・治療法の開発
日本病理学会会誌, 2014, Not refereed, Not invited

Efficacy of a whole particle vaccine against H7N9 influenza virus in cynomolgus macaques
Proceedings of the Japanese Society for Immunology, 2014, Not refereed, Not invited

iPS研究の前臨床試験のためのカニクイザルMHC遺伝子の多型解析
SHIINA TAKASHI; YAMADA SACHIHO; TANAKA KEIKO; KAMETANI YOSHIE; IWATANI CHIZURU; TSUCHIYA HIDEAKI; ITO YASUSHI; YAMANAKA HISASHI; NAKAGAWA HIROSHI; OTA MASAHO; INOKO HIDETOSHI; OGASAWARA KAZUMASA
再生医療, 28 Feb. 2013, Not refereed, Not invited

カニクイザルにおけるインフルエンザウイルス全粒子ワクチンの有効性
小笠原一誠; 有方雅彦; 仲山美沙子; 石垣宏仁; 石田英晃; LOI Pham Van; 伊藤靖
滋賀医学, 2013

ワクチニアウイルスDIs株を母体としたインフルエンザHA組換えワクチンの混合接種によるカニクイザルでの発症防御効果
宗片圭祐; 安井文彦; 伊藤靖; 石井孝司; 七戸新太郎; 喜田宏; 小笠原一誠; 小原道法
日本ワクチン学会学術集会プログラム・抄録集, 2013, Not refereed, Not invited

Pathogenicity of pandemic (H1N1) 2009 influenza A virus in immunosuppressed cynomolgus monkeys
Proceedings of the Japanese Society for Immunology, 2013, Not refereed, Not invited

A case of gastrointestinal stromal tumor arisen from the stomach detected by ultrasonography in a health checkup and requiring distinction from cystic tumor of the pancreas
INOUE Akitoshi; IMOTO Katsuji; YAMASAKI Michio; SAKAMOTO Tsutomu; ITOH Yasushi
GASTRIC CANCER, 2013, Not refereed, Not invited

全粒子ワクチンにより誘導されたインフルエンザウイルス特異的カニクイザルキラーT細胞の免疫記憶の解析
日本病理学会会誌, 2013, Not refereed, Not invited

Pathogenicity of pandemic (H1N1) 2009 influenza A virus in immunosuppressed cynomolgus monkeys
Proceedings of the Japanese Society for Immunology, 2013, Not refereed, Not invited

An inactivated whole particle vaccine induced memory immune responses against pandemic (H1N1) 2009 influenza virus in cynomolgus monkeys carrying Mafa-A1*052:02
第１６回日本ワクチン学会学術集会, 2012, Not refereed, Not invited

Therapeutic efficacy of a human-mouse chimeric anti-H5 hemagglutinin antibody on lethal H5N1 highly pathogenic avian influenza virus infection in cynomolgus macaques
Proceedings of the Japanese Society for Immunology, 2012, Not refereed, Not invited

An inactivated whole particle vaccine induced memory immune responses against pandemic (H1N1) 2009 influenza virus in cynomolgus monkeys carrying Mafa-A1*052:02
第１６回日本ワクチン学会学術集会, 2012, Not refereed, Not invited

Therapeutic efficacy of a human-mouse chimeric anti-H5 hemagglutinin antibody on lethal H5N1 highly pathogenic avian influenza virus infection in cynomolgus macaques
Proceedings of the Japanese Society for Immunology, 2012, Not refereed, Not invited

Identification of pandemic influenza virus NP peptides bound to cynomolgus macaque MHC class I Mafa-A1*5202 and stimulating CTL responses
XV International Congress of Virology, 2011, Not refereed, Not invited

Influenza virus peptides specifically bound to cynomolgus macaque major histocompatibility complex class I Mafa-A1*5202
Proceedings of the Japanese Society for Immunology, 2011, Not refereed, Not invited

霊長類モデルを用いたパンデミック(H1N1)2009インフルエンザに対する全粒子ワクチンの効果の検証
日本病理学会誌, 2011, Not refereed, Not invited

Identification of pandemic influenza virus NP peptides bound to cynomolgus macaque MHC class I Mafa-A1*5202 and stimulating CTL responses
XV International Congress of Virology, 2011, Not refereed, Not invited

Influenza virus peptides specifically bound to cynomolgus macaque major histocompatibility complex class I Mafa-A1*5202
Proceedings of the Japanese Society for Immunology, 2011, Not refereed, Not invited

MHC全遺伝子ホモ接合体カニクイザルの特定
椎名 隆; 北 夕紀; 田中 景子; 河野 あづみ; 鈴木 進悟; 細道 一善; 勝山 善彦; 土屋 英明; 小田部 耕二; 坂本 憲吾; 倉田 昌明; 野村 護; 山中 久; 中川 博司; 伊藤 靖; 太田 正穂; 猪子 英俊; 鳥居 隆三; 小笠原 一誠
MHC: Major Histocompatibility Complex, Aug. 2010, Not refereed, Not invited
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2010&ichushi_jid=J03628&link_issn=&doc_id=20100825330035&doc_link_id=%2Fcc1mhcom%2F2010%2F001702%2F035%2F0156-0156%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcc1mhcom%2F2010%2F001702%2F035%2F0156-0156%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

An inactivated whole particle vaccine from a non-pathogenic virus library confers protective immunity against H1N1 pandemic influenza virus more effectively than dose a split vaccine in cynomolgus macaques
International Immunology, 2010, Not refereed, Not invited

カニクイザルモデルを用いたパンデミック(H1N1)2009インフルエンザウイルス感染による炎症反応の解析
日本病理学会会誌, 2010, Not refereed, Not invited

カニクイザルを用いたインフルエンザウイルス感染後に残存するウイルス抗原分布の解析
仲山美沙子; 伊藤靖; 石垣宏仁; 小笠原一誠
日本病理学会会誌, 2010, Not refereed, Not invited

An inactivated whole particle vaccine from a non-pathogenic virus library confers protective immunity against H1N1 pandemic influenza virus more effectively than dose a split vaccine in cynomolgus macaques
International Immunology, 2010, Not refereed, Not invited

Inhibition of Transforming Growth Factor-beta-Mediated Immunosuppression in Tumor-Draining Lymph Nodes Augments Antitumor Responses by Various Immunologic Cell Types
Takuya Fujita; Koji Teramoto; Yoshitomo Ozaki; Jun Hanaoka; Noriaki Tezuka; Yasushi Itoh; Tohru Asai; Shozo Fujino; Keiichi Kontani; Kazumasa Ogasawara
CANCER RESEARCH, Jun. 2009, Not refereed, Not invited

Immunotherapy for Refractory Solid Cancer : From Cell Therapy to Direct Hemo-Perfusion
Ueda Yuji; Teramoto Kazuo; Itoh Yasushi; Shimagaki Masaaki; Hokari Naoto; Iwamoto Arihiro; Yamamoto Yoshiki; Yamagishi Hisakazu; Ogasawara Kazumasa
日本アフェレシス学会雑誌, 2009

Inflammatory responses induced by 2009 swine-origin H1N1 influenza virus infection in cynomolgus macaques
Proceedings of the Japanese Society for Immunology, 2009, Not refereed, Not invited

Immunological effects induced by immunization of C57BL/6 mice with detergent-insoluble raft icrodomains of synergeneic cancer cell lines or human renal cancer cell line ACHN cells
Proceedings of the Japanese Society for Immunology, 2009, Not refereed, Not invited

An analysis of immature myeloid cells in tumor bearing mice
Proceedings of the Japanese Society for Immunology, 2009, Not refereed, Not invited

カニクイザルを用いたH7N7型高病原性鳥インフルエンザウイルスワクチンの有効性検証
伊藤靖; 石垣宏仁; 別所美沙子; 小笠原一誠
日本病理学会会誌, 2009, Not refereed, Not invited

Transient abnormal myelopoiesis (TAM)の死産児の一剖検例
石垣宏仁; 別所美佐子; 伊藤靖; 小笠原一誠
日本病理学会会誌, 2009, Not refereed, Not invited

IL-10がキラーT細胞の免疫記憶に及ぼす影響の解析
別所美沙子; 伊藤靖; 石垣宏仁; 小笠原一誠
日本病理学会会誌, 2009, Not refereed, Not invited

カニクイザルを用いた高病原性鳥インフルエンザウイルスに対するワクチンの防御効果の判定
伊藤靖; 尾崎弘一; 曽田公輔; 迫田義博; 石垣宏仁; 仲山美沙子; 石田英晃; 永田智也; 三宅太一郎; 喜田宏; 喜田宏; 小笠原一誠
第１３回日本ワクチン学会学術集会プログラム・抄録集, 2009, Not refereed, Not invited

Effects of IL-10 on the generation of memory CTL specific for influenza virus
Proceedings of the Japanese Society for Immunology, 2009, Not refereed, Not invited

Inflammatory responses induced by 2009 swine-origin H1N1 influenza virus infection in cynomolgus macaques
Proceedings of the Japanese Society for Immunology, 2009, Not refereed, Not invited

Immunological effects induced by immunization of C57BL/6 mice with detergent-insoluble raft icrodomains of synergeneic cancer cell lines or human renal cancer cell line ACHN cells
Proceedings of the Japanese Society for Immunology, 2009, Not refereed, Not invited

An analysis of immature myeloid cells in tumor bearing mice
Proceedings of the Japanese Society for Immunology, 2009, Not refereed, Not invited

高病原性H5N1鳥インフルエンザウイルスのサルにおける病原性の比較
村本裕紀子; 伊藤靖; 田村大輔; 坂井(田川)優子; 今井博貴; 岡本貴世子; 石垣宏仁; 新矢恭子; LE THI QUYNH Mai; 小笠原一誠; 河岡義裕
日本ウイルス学会学術集会プログラム・抄録集, 2008

「免疫難病・感染症等の先進医療技術」「インフルエンザウイルス感染過程の解明とその応用」サルにおける高病原性H5N1鳥インフルエンザウイルスの病原性比較
村本裕紀子; 伊藤靖; 田村大輔; 坂井(田川)優子; 今井博貴; 岡本貴世子; 石垣宏仁; 新矢恭子; MAI Le Thi Quynh; 小笠原一誠; 河岡義裕
免疫難病・感染症等の先進医療技術 第5回(最終)公開シンポジウム要旨集 平成20年, 2008

腫瘍内浸潤未熟ミエロイド細胞と担癌個体脾臓に含まれる未熟ミエロイド細胞の比較検討
石垣宏仁; 伊藤靖; 小笠原一誠
日本病理学会会誌, 2008

Effects of IL-10 on the generation of memory CTL specific for influenza virus NP peptide
Proceedings of the Japanese Society for Immunology, 2008, Not refereed, Not invited

Prolonged presentation of influenza virus NP peptides in mediastinal lymph nodes after H3N2 influenza virus infection
Proceedings of the Japanese Society for Immunology, 2008, Not refereed, Not invited

Whole particle vaccines dereived from a non-pathogenic virus library induce antibodies and CD8 T cell responses against H7N7 subtype highly pathogenic avian influenza virus infection in cynomolgus macaques.
Proceedings of the Japanese Society for Immunology, 2008, Not refereed, Not invited

CRTAM regulate CD8+ T cell proliferation in regional lymph nodes through the interaction with CD8a+ dendritic cell
Proceedings of the Japanese Society for Immunology, 2008, Not refereed, Not invited

カニクイザルを用いた高病原性トリインフルエンザウイルスに対する全粒子不活化ワクチンの有効性の検証
伊藤靖; 石垣宏仁; 小笠原一誠
日本病理学会誌, 2008, Not refereed, Not invited

霊長類を用いたH5N1型高病原性鳥インフルエンザウイルスに対する弱毒型ウイルスライブラリー由来全粒子ワクチンの防御効果の解析
臨床免疫・アレルギー科, 2008, Not refereed, Not invited

Effects of IL-10 on the generation of memory CTL specific for influenza virus NP peptide
Proceedings of the Japanese Society for Immunology, 2008, Not refereed, Not invited

Prolonged presentation of influenza virus NP peptides in mediastinal lymph nodes after H3N2 influenza virus infection
Proceedings of the Japanese Society for Immunology, 2008, Not refereed, Not invited

Whole particle vaccines dereived from a non-pathogenic virus library induce antibodies and CD8 T cell responses against H7N7 subtype highly pathogenic avian influenza virus infection in cynomolgus macaques.
Proceedings of the Japanese Society for Immunology, 2008, Not refereed, Not invited

CRTAM regulate CD8+ T cell proliferation in regional lymph nodes through the interaction with CD8a+ dendritic cell
Proceedings of the Japanese Society for Immunology, 2008, Not refereed, Not invited

脳腫瘍の一例
ISHIGAKI HIROHITO; ITO YASUSHI; OGASAWARA KAZUMASA; OKABE HIDETOSHI; NAKASU SATOSHI; YAMAMOTO MAYUMI; TAGA TAKASHI; OTA SHIGERU
Neuro-Oncologyの進歩, Jun. 2007, Not refereed, Not invited

CpG/anti-IL-10/peptideを用いた腫瘍免疫療法の検討
石垣宏仁; 永田智也; 山本依志子; 石田英晃; 伊藤靖; 小笠原一誠
滋賀医学, 2007

A whole particle vaccine prepared from an apathogenic H5N1 avian influenza virus strain induced protective immunity against infection of hifgly pathogenic avian influenza viruses in cynomolgus macaques
Proceedings of the Japanese Society for Immunology, 2007, Not refereed, Not invited

Protective immune responses induced by inoculation of apathogenic H5N1 influenza virus particles inactivated with formalin against H5N1 highly pathogenic avian influenza virus infection in mice
Proceedings of the Japanese Society for Immunology, 2007, Not refereed, Not invited

Peptide coupled to surface of a kind of liposome protect infection of influenza viruses
Proceedings of the Japanese Society for Immunology, 2007, Not refereed, Not invited

CRTAM confers retention in lymph nodes and efficient delivery to effector sites of antigen-specific CD8+ T cells
Proceedings of the Japanese Society for Immunology, 2007, Not refereed, Not invited

An analysis of immature myeloid cells in tumor bearing mice
Proceedings of the Japanese Society for Immunology, 2007, Not refereed, Not invited

ホルマリン不活化全粒子ワクチンはインフルエンザウイルスNP特異的キラーT細胞を誘導する
伊藤靖; 石垣宏仁; 小笠原一誠
日本病理学会会誌, 2007, Not refereed, Not invited

A whole particle vaccine prepared from an apathogenic H5N1 avian influenza virus strain induced protective immunity against infection of hifgly pathogenic avian influenza viruses in cynomolgus macaques
Proceedings of the Japanese Society for Immunology, 2007, Not refereed, Not invited

Protective immune responses induced by inoculation of apathogenic H5N1 influenza virus particles inactivated with formalin against H5N1 highly pathogenic avian influenza virus infection in mice
Proceedings of the Japanese Society for Immunology, 2007, Not refereed, Not invited

Peptide coupled to surface of a kind of liposome protect infection of influenza viruses
Proceedings of the Japanese Society for Immunology, 2007, Not refereed, Not invited

CRTAM confers retention in lymph nodes and efficient delivery to effector sites of antigen-specific CD8+ T cells
Proceedings of the Japanese Society for Immunology, 2007, Not refereed, Not invited

An analysis of immature myeloid cells in tumor bearing mice
Proceedings of the Japanese Society for Immunology, 2007, Not refereed, Not invited

Differentiated splenic ImC from tumor bearing mice suppress T cell proliferation
Proceedings of the Japanese Society for Immunology, 2006, Not refereed, Not invited

Preparation and functional analysis of tumor-inflitrating stroma cells using bone marrow chimera
Proceedings of the Japanese Society for Immunology, 2006, Not refereed, Not invited

Induction of cytotoxic T lymphocyte and antibody responses in mice by inoculation of H5N1 influenza virus particles inactivated with formalin
Proceedings of the Japanese Society for Immunology, 2006, Not refereed, Not invited

CTL responses in primary and secondary influenza virus infection analyzed by in vivo CTL assay
Proceedings of the Japanese Society for Immunology, 2006, Not refereed, Not invited

Physiological role of CRTAM expression in vivo immunity
Proceedings of the Japanese Society for Immunology, 2006, Not refereed, Not invited

Differentiated splenic ImC from tumor bearing mice suppress T cell proliferation
Proceedings of the Japanese Society for Immunology, 2006, Not refereed, Not invited

Preparation and functional analysis of tumor-inflitrating stroma cells using bone marrow chimera
Proceedings of the Japanese Society for Immunology, 2006, Not refereed, Not invited

Induction of cytotoxic T lymphocyte and antibody responses in mice by inoculation of H5N1 influenza virus particles inactivated with formalin
Proceedings of the Japanese Society for Immunology, 2006, Not refereed, Not invited

CTL responses in primary and secondary influenza virus infection analyzed by in vivo CTL assay
Proceedings of the Japanese Society for Immunology, 2006, Not refereed, Not invited

Physiological role of CRTAM expression in vivo immunity
Proceedings of the Japanese Society for Immunology, 2006, Not refereed, Not invited

The analysis and characterization of tumor involving stromal cells
日本免疫学会総会・学術集会記録, 2005, Not refereed, Not invited

in vivo CTL assayを用いたペプチド抗原によるキラーT細胞の誘導条件の解析
日本免疫学会総会・学術集会記録, 2005, Not refereed, Not invited

炎症と担癌状態における脾臓内Gr-1+CD11b+ immature myeloid cellsの免疫抑制にかかわる機能解析
日本免疫学会総会・学術集会記録, 2005, Not refereed, Not invited

The analysis and characterization of tumor involving stromal cells
日本免疫学会総会・学術集会記録, 2005, Not refereed, Not invited

The role of antigen presenting cells and partial agonists in Th1 and Th2 differentiation
Kyoto T Cell Conference The 3rd International Workshop, 2002, Not refereed, Not invited

Differential TCR Signaling Induced by Agonist Ligand in Polarized Th1 and Th2 Cells with Identical Antigen Receptors
KEYSTONE SYMPOSIA, 2002, Not refereed, Not invited

クローン病モデルSAMP1/Yitのリンパ球表面マーカーの検討
2002日本免疫学会総会・学術集会記録, 2002, Not refereed, Not invited

CD40 crosslinkingによりIL-12を産生する樹状細胞分画の解析
2002日本免疫学会総会・学術集会記録, 2002, Not refereed, Not invited

The role of antigen presenting cells and partial agonists in Th1 and Th2 differentiation
Kyoto T Cell Conference The 3rd International Workshop, 2002, Not refereed, Not invited

Differential TCR Signaling Induced by Agonist Ligand in Polarized Th1 and Th2 Cells with Identical Antigen Receptors
KEYSTONE SYMPOSIA, 2002, Not refereed, Not invited

AGONIST LIGAND INDUCES DIFFERENTIAL TCR PHOSPHORYLATION IN POLARIZED TH1 AND TH2 CELLS WITH IDENTICAL ANTIGEN RECEPTORS
11th International Congress of Immunology, 2001, Not refereed, Not invited

TCRトランスジェニックマウス由来のTh1細胞とTh2細胞のTCRリン酸化の差異
日本病理学会会誌, 2001, Not refereed, Not invited

Th1/Th2細胞のＴＣＲシグナルと表面マーカーの細胞分裂に伴う変化
第21回滋賀血液・免疫研究会, 2001, Not refereed, Not invited

Th1/Th2細胞のＴＣＲシグナル差異と表面マーカーの関係
Kyoto T Cell Conference 第11回集会抄録, 2001, Not refereed, Not invited

TGFβＲ・-Igの腫瘍関連抗原特異的細胞障害性T細胞活性の増強効果の検証
第5回基盤的癌免疫研究会総会抄録, 2001, Not refereed, Not invited

Th1/2細胞の分化におけるpartial agonistと抗原提示細胞の役割の解析
日本免疫学会総会・学術集会記録, 2001, Not refereed, Not invited

SHP-2ドミナントネガティブマウスを用いたT細胞反応の解析
日本免疫学会総会・学術集会記録, 2001, Not refereed, Not invited

AGONIST LIGAND INDUCES DIFFERENTIAL TCR PHOSPHORYLATION IN POLARIZED TH1 AND TH2 CELLS WITH IDENTICAL ANTIGEN RECEPTORS
11th International Congress of Immunology, 2001, Not refereed, Not invited

髄膜癌腫症をきたしたIIb型早期胃癌の1剖検例 転移経路の検討
FUKUOKA JUN'YA; KOJIMA CHIKAKO; TAKIKITA MIKIKO; KAJINO KIICHI; ITO YASUSHI; OGASAWARA KAZUMASA
リンパ学, 30 Nov. 2000, Not refereed, Not invited

Differential TCR Signaling by Differentiated Th1 and Th2 Cells with IdenticalReceptors
The IXth International Symposium on Molecular Cell Biology of Macrophages 2000, 2000, Not refereed, Not invited

Meningeal carcinomatosis from T1gastric cancer:An autopsy case report
XXIII International Congress of THE INTERNATIONAL ACADEMY OF PATHOLOGY, 2000, Not refereed, Not invited

同一のT細胞抗原レセプターを持つTh1細胞とTh2細胞のTCRシグナルの差異
第19回滋賀血液・免疫研究会, 2000, Not refereed, Not invited

同一のT細胞抗原レセプターを持つTh1細胞とTh2細胞のTCRリン酸化の差異
日本免疫学会総会・学術集会記録, 2000, Not refereed, Not invited

Differential TCR Signaling by Differentiated Th1 and Th2 Cells with IdenticalReceptors
The IXth International Symposium on Molecular Cell Biology of Macrophages 2000, 2000, Not refereed, Not invited

Meningeal carcinomatosis from T1gastric cancer:An autopsy case report
XXIII International Congress of THE INTERNATIONAL ACADEMY OF PATHOLOGY, 2000, Not refereed, Not invited

Cell response threshold and response hierarchy analyzed at the single cell level.
Y Itoh; RN Germain
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Jan. 1997, Not refereed, Not invited

抗原やペプチドを用いたトレランス誘導
小笠原一誠; 金田利華; 伊藤 靖; 鷹見公貴; 梶野喜一; 加藤正仁; 小野江和則
日本臨床免疫学会会誌, 1994, Not refereed, Not invited

Fine analysis of recognition sites of monoclonal antibodies, 1B7 and 1E4, using L cell transfectants of recombinant mouse MHC class II genes.
Itoh Yasushi; Ogasawara Kazumasa; Onoe Kazunori
Collected papers from the Institute of Immunological Science Hokkaido University, 1993

ペプチト抗原p43-58特異的Ｔ細胞抗原レセプター(TCR)のVβ鎖の解析
Wang Bingyan; 伊藤 靖; 後藤田敏彦; 小笠原一誠; 小野江和則
医学のあゆみ, 1991, Not refereed, Not invited

Antigen presenting ability of low density adherent cells from spleen or thymus of C3H mice.
WAMBUA P P; 後藤田敏彦; 伊藤靖; 根岸泉; 福士規子; 小笠原一誠; 小野江和則
日本免疫学会総会・学術集会記録, Oct. 1990, Not refereed, Not invited

創薬研究者がこれだけは知っておきたい最新のウイルス学
Contributor, 第４章 創薬のためのウイルス感染モデルの作製と薬剤評価 第７節 霊長類モデルを用いた新型コロナウイルス感染症研究
技術情報協会, Aug. 2021

脱リン酸化酵素のTリンパ球における役割
上原記念生命科学財団研究報告集, 2002, Not refereed

病態治療論（総論）
滋賀県堅田看護専門学校

病理学
長浜バイオ大学

医学生物学
長浜バイオ大学

免疫学
滋賀医科大学

病態発生学
滋賀医科大学

日本ワクチン学会

日本癌学会

日本ウイルス学会

日本病理学会

日本免疫学会

霊長類モデルを用いたワクチン評価に関するサポート機関
Oct. 2022, Mar. 2027

免疫抑制性T細胞吸着カラムによる免疫低下疾患治療法の開発
滋賀医科大学
2023, 2024

Study on molecular mechanism of collagen-induced arthritis in cynomolgus monkeys
Grant-in-Aid for Scientific Research (B)
Tokai University
01 Apr. 2019, 31 Mar. 2022

Galectin-3による生体内幹細胞障害の機序解明と治療効果の検証
Grant-in-Aid for Scientific Research (B)
Tottori University
01 Apr. 2019, 31 Mar. 2022

Development of diagnosis and therapy for aging using a nonhuman primate model of premature aging
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
01 Apr. 2019, 31 Mar. 2022

Mechanism of plasma membrane expression of endoplasmic reticulum chaperone proteins
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
01 Apr. 2019, 31 Mar. 2022

Analysis of immune responses and search for therapeutic and vaccine targets against SARS-CoV-2 and seasonal coronavirus using a nonhuman primate model with severe diseases
Apr. 2021, Mar. 2022

Establishment of infrastructure for promotion of development of antiviral drugs and vaccines against COVID-19 using a nonhuman primate model
Jan. 2021, Mar. 2022

カニクイザルモデルを用いた新型コロナウイルスに対する組換えワクチンの開発
May 2020, Mar. 2021

Treatment of DSS colitis with MSCs derived from MHC-homozygous iPSCs with using cynomolgus macaque
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
01 Apr. 2017, 31 Mar. 2020

Search for host factors in severe influenza virus infection using a nonhuman primate model
Grant-in-Aid for Scientific Research (B)
Shiga University of Medical Science
01 Apr. 2015, 31 Mar. 2018

Development of a premature aging syndrome non-human primate model
Grant-in-Aid for Challenging Exploratory Research
Shiga University of Medical Science
01 Apr. 2014, 31 Mar. 2017

Treatment by a column absorbing immunosuppressing cells in macaques with endometriosis
Grant-in-Aid for Challenging Exploratory Research
Shiga University of Medical Science
01 Apr. 2014, 31 Mar. 2016

Development of a non-human primate autoimmune model using autoreactive lymphocytes derived from induced pluripotent stem cells
Grant-in-Aid for Challenging Exploratory Research
Shiga University of Medical Science
2011, 2013

Establishment of a macaque cancer model using cancer cells derived from MHC homozygous macaque iPS cells
Grant-in-Aid for Scientific Research (B)
Shiga University of Medical Science
2010, 2012

Antibody therapy against novel influenza virus infection using anImmunosuppressed non-human primate model
Grant-in-Aid for Scientific Research (B)
Shiga University of Medical Science
2010, 2012

Establishment of a network of model-monkey supply forhuman medical researches
Grant-in-Aid for Scientific Research (C)
Shiga University of Medical Science
2008, 2012

Elucidation of MHC polymorphism information in cynomolgus macaque(Macaca Fascicularis)
Grant-in-Aid for Scientific Research (B)
Tokai University
2009, 2011

リンパ系における脱リン酸化酵素の研究
Apr. 2001, Mar. 2002

分泌型TGF-βレセプターII遺伝子導入アデノウイルス投与による腫瘍拒絶の試み
Grant-in-Aid for Scientific Research on Priority Areas (C)
Shiga University of Medical Science
2001, 2001

Tリンパ球の抗原認識とシグナル伝達機構の研究
2000

Tリンパ球による免疫学的記憶の研究
2000

特許US9,127,250, 特願US9,127,250, IMMUNOSUPPRESSIVE CELL-CAPTURING MATERIAL AND IMMUNOSUPPRESSIVE CELL-CAPTURING COLUMN
Kazumasa Ogasawara; Kazuo Teramoto; Yuji Ueda; Yasushi Itoh; Hirohito Ishigaki

免疫抑制細胞捕集材及び免疫抑制性細胞捕集用カラム